2020
Cannabidiol in treatment of refractory epileptic spasms: An open-label study
Herlopian A, Hess EJ, Barnett J, Geffrey AL, Pollack SF, Skirvin L, Bruno P, Sourbron J, Thiele EA. Cannabidiol in treatment of refractory epileptic spasms: An open-label study. Epilepsy & Behavior 2020, 106: 106988. PMID: 32169600, DOI: 10.1016/j.yebeh.2020.106988.Peer-Reviewed Original ResearchConceptsRefractory epileptic spasmsEpileptic spasmsResponder rateAdjunctive therapyCBD treatmentInvestigational new drug trialsOpen-label studyMonths of treatmentSafe adjunctive therapyNew drug trialsInstitutional review boardSubjective reportsBaseline medicationsCBD initiationElectrographic findingsHypsarrhythmia patternClinical responseSeizure frequencyAdverse eventsClinical efficacyElectrographic changesSubjective improvementTarget dosageDrug trialsInitial dosage
2017
Predictive Value of Electrocorticography in Patients With Mesial Temporal Lobe Epilepsy Undergoing Selective Amygdalohippocampectomy
Herlopian A, Shihabuddin B. Predictive Value of Electrocorticography in Patients With Mesial Temporal Lobe Epilepsy Undergoing Selective Amygdalohippocampectomy. Journal Of Clinical Neurophysiology 2017, 34: 370-374. PMID: 28306691, DOI: 10.1097/wnp.0000000000000376.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyMesial temporal sclerosisTemporal lobe epilepsyPostoperative seizure freedomSelective amygdalohippocampectomyLobe epilepsyIntraoperative electrocorticographySeizure freedomPredictive valueStandard temporal lobectomyNormal brain MRIElectrocorticography findingsSeizure outcomeTemporal sclerosisPostoperative outcomesConsecutive patientsTemporal lobectomyMean durationSingle neurosurgeonRetrospective analysisBrain MRIPatientsEpilepsySeizuresElectrocorticography