1998
The Adeno-Associated Virus Rep78 Major Regulatory Protein Binds the Cellular TATA-Binding Proteinin Vitroandin Vivo
Hermonat P, Santin A, Batchu R, Zhan D. The Adeno-Associated Virus Rep78 Major Regulatory Protein Binds the Cellular TATA-Binding Proteinin Vitroandin Vivo. Virology 1998, 245: 120-127. PMID: 9614873, DOI: 10.1006/viro.1998.9144.Peer-Reviewed Original ResearchConceptsPossible protein-protein interactionsBasal transcription factorsMajor regulatory proteinTranscription factorsRegulatory proteinsTwo-hybrid systemTranscription initiation complexProtein-protein interactionsNumerous interactionsYeast GAL4Human TATAInitiation complexHeterologous promoterAmino halfRep78Biological roleGene expressionWestern analysisVivo interactionAAV promotersPromoterTATAProteinElectrophoretic mobilityRegulatory ability
1997
Multiple cellular proteins are recognized by the adeno‐associated virus Rep78 major regulatory protein and the amino‐half of Rep78 is required for many of these interactions
Hermonat P, Carter C, Parham G, Quirk J, Santin A. Multiple cellular proteins are recognized by the adeno‐associated virus Rep78 major regulatory protein and the amino‐half of Rep78 is required for many of these interactions. IUBMB Life 1997, 43: 409-420. PMID: 9350349, DOI: 10.1080/15216549700204201.Peer-Reviewed Original ResearchConceptsMultiple cellular proteinsCellular proteinsHeterologous gene expressionHuman chromosome 19Multi-functional proteinMajor regulatory proteinSite-specific integrationAAV DNA replicationLarge T antigenRep78 proteinReplication proteinsDNA replicationProtein interactionsRegulatory proteinsTranscriptional levelChromosome 19Rep78Assay systemGene expressionCellular extractsT antigenProteinAAV DNASpecific integrationCoimmunoprecipitation
1996
Role of the terminal repeat GAGC trimer, the major Rep78 binding site, in adeno‐associated virus DNA replication
Bishop BM, Santin AD, Quirk JG, Hermonat PL. Role of the terminal repeat GAGC trimer, the major Rep78 binding site, in adeno‐associated virus DNA replication. FEBS Letters 1996, 397: 97-100. PMID: 8941722, DOI: 10.1016/s0014-5793(96)01149-0.Peer-Reviewed Original Research