2022
In Silico Analysis of the Multi-Targeted Mode of Action of Ivermectin and Related Compounds
Aminpour M, Cannariato M, Preto J, Safaeeardebili M, Moracchiato A, Doria D, Donato F, Zizzi E, Deriu M, Scheim D, Santin A, Tuszynski J. In Silico Analysis of the Multi-Targeted Mode of Action of Ivermectin and Related Compounds. Computation 2022, 10: 51. DOI: 10.3390/computation10040051.Peer-Reviewed Original ResearchAnti-inflammatory pathwaySARS-CoV-2 virusAlpha 7 nicotinic acetylcholine receptorCholinergic anti-inflammatory pathwayAnti-viral effectsActivity of ivermectinNicotinic acetylcholine receptorsBiological mechanismsVagus nerveCytokine productionImmune cellsClinical studiesCD147 receptorViral penetrationAcetylcholine receptorsNeuronal tissueIvermectinMolecular targetsHigh affinitySpike glycoproteinPhysiological concentrationsMorbidityCOVID-19VirusReceptors
2015
Clostridium Perfringens Enterotoxin (CPE) and CPE-Binding Domain (c-CPE) for the Detection and Treatment of Gynecologic Cancers
Black JD, Lopez S, Cocco E, Schwab CL, English DP, Santin AD. Clostridium Perfringens Enterotoxin (CPE) and CPE-Binding Domain (c-CPE) for the Detection and Treatment of Gynecologic Cancers. Toxins 2015, 7: 1116-1125. PMID: 25835384, PMCID: PMC4417958, DOI: 10.3390/toxins7041116.Peer-Reviewed Original ResearchConceptsClostridium perfringens enterotoxinClaudin-3Claudin-4Perfringens enterotoxinAggressive human cancer cellsGynecologic malignanciesGynecologic cancerHuman cancer cellsOperative settingHuman tumorsCancer cellsPotential roleTumorsSurface proteinsEnterotoxinTreatmentHigh affinitySurgeryMalignancyCancerCytolysisReceptors
1996
Role of the terminal repeat GAGC trimer, the major Rep78 binding site, in adeno‐associated virus DNA replication
Bishop BM, Santin AD, Quirk JG, Hermonat PL. Role of the terminal repeat GAGC trimer, the major Rep78 binding site, in adeno‐associated virus DNA replication. FEBS Letters 1996, 397: 97-100. PMID: 8941722, DOI: 10.1016/s0014-5793(96)01149-0.Peer-Reviewed Original Research