2011
Primary human cervical carcinoma cells require human papillomavirus E6 and E7 expression for ongoing proliferation
Magaldi TG, Almstead LL, Bellone S, Prevatt EG, Santin AD, DiMaio D. Primary human cervical carcinoma cells require human papillomavirus E6 and E7 expression for ongoing proliferation. Virology 2011, 422: 114-124. PMID: 22056390, PMCID: PMC3229657, DOI: 10.1016/j.virol.2011.10.012.Peer-Reviewed Original ResearchConceptsCervical carcinoma cellsCervical cancer cellsHuman papillomavirus E6Human cervical carcinoma cellsCarcinoma cellsPrimary cervical cancer cellsCancer cellsPapillomavirus E6Cervical carcinoma cell linesE2 proteinHuman cervical cancer cellsCarcinoma cell linesE7 expressionE7 oncogenesLow passage numberSerum-free conditionsCell surface receptorsSV40 infectionTumor suppressor pathwayCell linesPrimary cellsViral vectorsE6Suppressor pathwayPassage number
2004
The serine protease stratum corneum chymotryptic enzyme (kallikrein 7) is highly overexpressed in squamous cervical cancer cells
Santin AD, Cane' S, Bellone S, Bignotti E, Palmieri M, De Las Casas LE, Roman JJ, Anfossi S, O'Brien T, Pecorelli S. The serine protease stratum corneum chymotryptic enzyme (kallikrein 7) is highly overexpressed in squamous cervical cancer cells. Gynecologic Oncology 2004, 94: 283-288. PMID: 15297163, DOI: 10.1016/j.ygyno.2004.05.023.Peer-Reviewed Original ResearchConceptsCervical cancer cell linesStratum corneum chymotryptic enzymeSCCE expressionCancer cell linesCervical tumorsParaffin-embedded cervical cancer specimensTumor tissueRT-PCRSquamous cervical cancerNormal cervical epithelial cellsCervical cancer specimensSerine protease stratum corneum chymotryptic enzymeHuman cervical tumorsCervical epithelial cellsCervical cancer therapyNormal cervical keratinocytesCell linesCervical cancer cellsNovel molecular targetsMetastatic involvementRecurrent diseaseChymotryptic enzymeLymph nodesCervical cancerPrimary adenocarcinoma
1998
Effects of Retinoic Acid Combined with Irradiation on the Expression of Major Histocompatibility Complex Molecules and Adhesion/Costimulation Molecules ICAM-1 in Human Cervical Cancer
Santin A, Hermonat P, Ravaggi A, Chiriva-Internati M, Hiserodt J, Pecorelli S, Parham G. Effects of Retinoic Acid Combined with Irradiation on the Expression of Major Histocompatibility Complex Molecules and Adhesion/Costimulation Molecules ICAM-1 in Human Cervical Cancer. Gynecologic Oncology 1998, 70: 195-201. PMID: 9740690, DOI: 10.1006/gyno.1998.5060.Peer-Reviewed Original ResearchConceptsIntercellular adhesion molecule-1Class II surface antigensICAM-1 antigenSurface antigenMHC class ICervical cancer cellsClass IRetinoic acidCervical cancerHigh dosesUpregulated HLA class ITumor cellsSiHa cervical cancer cellsMajor histocompatibility complex class ICancer cellsHistocompatibility complex class IMajor histocompatibility complex moleculesMolecules ICAM-1Adhesion molecule-1HLA class IICAM-1 moleculesUntreated tumor cellsHuman cervical cancerCervical cancer therapyComplex class IEffects of retinoic acid combined with interferon‐gamma on the expression of major‐histocompatibility‐complex molecules and intercellular adhesion molecule‐1 in human cervical cancer
Santin A, Hermonat P, Ravaggi A, Chiriva‐Internati M, Hiserodt J, Tian E, Carter C, Pecorelli S, Parham G. Effects of retinoic acid combined with interferon‐gamma on the expression of major‐histocompatibility‐complex molecules and intercellular adhesion molecule‐1 in human cervical cancer. International Journal Of Cancer 1998, 75: 254-258. PMID: 9462716, DOI: 10.1002/(sici)1097-0215(19980119)75:2<254::aid-ijc14>3.0.co;2-d.Peer-Reviewed Original ResearchConceptsMHC class IIIFN-gammaHuman cervical cancerCervical cancerHLA classTrans retinoic acidMHC classI mRNA expressionRetinoic acidSurface antigenTumor cellsIntercellular adhesion molecule-1Biologic response modifiersICAM-1 antigenAdhesion molecule-1ICAM-1 moleculesUntreated tumor cellsCell linesCervical cancer cellsICAM-1 surfaceCervical carcinoma cell linesAnti-proliferative effectsHuman cervical cancer cellsHuman cervical carcinoma cell lineResponse modifiersThe effects of irradiation on the expression of a tumour rejection antigen (heat shock protein gp96) in human cervical cancer
Santin AD, Hermonat PL, Ravaggi A, Chiriva-Internati M, Hiserodt JC, Batchu RB, Pecorelli S, Parham GP. The effects of irradiation on the expression of a tumour rejection antigen (heat shock protein gp96) in human cervical cancer. International Journal Of Radiation Biology 1998, 73: 699-704. PMID: 9690688, DOI: 10.1080/095530098141951.Peer-Reviewed Original ResearchConceptsTumor rejection antigensHeat shock protein gp96Shock protein gp96Human cervical cancerCervical carcinoma cell linesRejection antigensHigh dosesHuman cervical carcinoma cell lineCervical cancerCarcinoma cell linesTumor cellsMajor histocompatibility complex class ILocal radiation therapyHistocompatibility complex class IBiologic response modifiersCo-stimulation moleculesComplex class ICell linesCervical cancer cellsDose-dependent mannerViral antigensResponse modifiersICAM-1Radiation therapyGp96 mRNA
1997
Effects of irradiation on the expression of major histocompatibility complex class I antigen and adhesion costimulation molecules ICAM-1 in human cervical cancer
Santin A, Hermonat P, Hiserodt J, Chiriva-Internati M, Woodliff J, Theus J, Barclay D, Pecorelli S, Parham G. Effects of irradiation on the expression of major histocompatibility complex class I antigen and adhesion costimulation molecules ICAM-1 in human cervical cancer. International Journal Of Radiation Oncology • Biology • Physics 1997, 39: 737-742. PMID: 9336157, DOI: 10.1016/s0360-3016(97)00372-6.Peer-Reviewed Original ResearchConceptsMHC class ISurface antigenClass IAntigen expressionICAM-1High dosesClass II surface antigensCell linesSiHa cervical cancer cellsMajor histocompatibility complex class IHistocompatibility complex class IICAM-1 antigenMolecules ICAM-1Cell replicationSurface antigen expressionHuman cervical cancerComplex class ICervical cancer cellsCervical carcinoma cell linesCervical cell linesHuman cervical carcinoma cell lineDifferent time pointsCervical cancerCarcinoma cell linesHigh radiation doses