2022
Neurogenic orthostatic hypotension after treatment with sorafenib
Wippel C, Deshpande H, Patwa H, Peixoto A. Neurogenic orthostatic hypotension after treatment with sorafenib. BMJ Case Reports 2022, 15: e247140. PMID: 36549761, PMCID: PMC9791444, DOI: 10.1136/bcr-2021-247140.Peer-Reviewed Original ResearchConceptsOrthostatic hypotensionVascular endothelial growth factor inhibitorsLower extremity weaknessNeurogenic orthostatic hypotensionPalpable abdominal massGrowth factor inhibitorsHistory of fatigueAppropriate chronotropic responseSupine hypertensionAbdominal painAutonomic testingExtremity weaknessAbdominal massSodium intakeChronotropic responseFactor inhibitorsCompression stockingsDesmoid tumorsLiberal fluidsSympathetic responseHypotensionTumor growthSorafenibGradual improvementTreatmentExcessive Blood Pressure Response to Clonidine in Hospitalized Patients With Asymptomatic Severe Hypertension
Hanna J, Ghazi L, Yamamoto Y, Simonov M, Shah T, Wilson F, Peixoto A. Excessive Blood Pressure Response to Clonidine in Hospitalized Patients With Asymptomatic Severe Hypertension. American Journal Of Hypertension 2022, 35: 433-440. PMID: 35038322, PMCID: PMC9088839, DOI: 10.1093/ajh/hpac004.Peer-Reviewed Original ResearchConceptsAsymptomatic severe hypertensionBlood pressure responseSevere hypertensionHospitalized patientsPressure responseExcessive blood pressure responseMean arterial pressure reductionMAP reductionAcute kidney injuryBlood pressure declineArterial pressure reductionHours of administrationClonidine doseKidney injuryPrimary endpointAdverse eventsIschemic eventsBlood pressureIll patientsClinical groundsMedian timePatient sexFemale sexVascular diseaseMultivariable model
2021
The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study
Moledina DG, Simonov M, Yamamoto Y, Alausa J, Arora T, Biswas A, Cantley LG, Ghazi L, Greenberg JH, Hinchcliff M, Huang C, Mansour SG, Martin M, Peixoto A, Schulz W, Subair L, Testani JM, Ugwuowo U, Young P, Wilson FP. The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study. American Journal Of Kidney Diseases 2021, 77: 490-499.e1. PMID: 33422598, PMCID: PMC7791318, DOI: 10.1053/j.ajkd.2020.12.007.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedCohort StudiesCOVID-19C-Reactive ProteinCreatinineDiureticsFemaleHospital MortalityHumansIntensive Care UnitsLength of StayMaleMiddle AgedProportional Hazards ModelsRenal DialysisRenal Insufficiency, ChronicRespiration, ArtificialRisk FactorsSARS-CoV-2Severity of Illness IndexUnited StatesVasoconstrictor AgentsConceptsAcute kidney injurySARS-CoV-2Cohort studyRisk factorsCOVID-19Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testingTime-updated Cox proportional hazards modelsDialysis-requiring acute kidney injuryYale New Haven Health SystemHigher inflammatory marker levelsMore acute kidney injuryCox proportional hazards modelMulticenter cohort studyHigh rateInflammatory marker levelsTraditional risk factorsProportional hazards modelCoronavirus disease 2019KDIGO criteriaNephrotoxin exposureKidney injuryInjury independentUnivariable analysisNasopharyngeal samplesMarker levels
2019
Seronegative autoimmune autonomic ganglionopathy from dual immune checkpoint inhibition in a patient with metastatic melanoma
Gao CA, Weber UM, Peixoto AJ, Weiss SA. Seronegative autoimmune autonomic ganglionopathy from dual immune checkpoint inhibition in a patient with metastatic melanoma. Journal For ImmunoTherapy Of Cancer 2019, 7: 262. PMID: 31623673, PMCID: PMC6796437, DOI: 10.1186/s40425-019-0748-0.Peer-Reviewed Original ResearchConceptsAutoimmune autonomic ganglionopathyImmune checkpoint inhibitor therapyMetastatic melanomaCheckpoint inhibitorsDual immune checkpoint inhibitionSympathetic nervous system responsesBackgroundImmune checkpoint inhibitorsCardiovascular autonomic testingCheckpoint inhibitor therapyImmune checkpoint inhibitionNervous system responsesEndocrine workupHypotension refractoryAutonomic testingImmunomodulatory therapyAdverse eventsCase presentationAFluid resuscitationInhibitor therapyCheckpoint inhibitionClinical outcomesDisease progressionNew symptomsEndocrine toxicityNivolumab
2018
Arterial stiffness in elderly patients with normotension and hypertension in Brazil
de Mendonça G, de Souza D, de Alvarenga Cunha Brunelli A, de Oliveira Peres C, Freitas EGB, Lacerda GN, Dorneles MC, Peixoto AJ, Ferreira‐Filho S. Arterial stiffness in elderly patients with normotension and hypertension in Brazil. Journal Of Clinical Hypertension 2018, 20: 1285-1293. PMID: 30039916, PMCID: PMC8031136, DOI: 10.1111/jch.13358.Peer-Reviewed Original ResearchConceptsAortic augmentation indexArterial stiffnessUncontrolled hypertensionCarotid-femoral pulse wave velocityHigher aortic augmentation indexCf-PWV levelsCf-PWV valuesBlood pressure levelsPulse wave velocityCross-sectional analysisElderly patientsAugmentation indexBP levelsCf-PWVEntire cohortNormotensionHypertensionOlder individualsOlder populationPatientsTonometry dataCore measuresCohortPressure levelsIndividuals
2008
Paroxysmal hypertension due to baroreflex failure
Zar T, Peixoto A. Paroxysmal hypertension due to baroreflex failure. Kidney International 2008, 74: 126-131. PMID: 18322544, DOI: 10.1038/ki.2008.30.Peer-Reviewed Original Research
2000
Reproducibility of ambulatory blood pressure monitoring in hemodialysis patients
Peixoto A, Santos S, Mendes R, Crowley S, Maldonado R, Orias M, Mansoor G, White W. Reproducibility of ambulatory blood pressure monitoring in hemodialysis patients. American Journal Of Kidney Diseases 2000, 36: 983-990. PMID: 11054355, DOI: 10.1053/ajkd.2000.19100.Peer-Reviewed Original ResearchConceptsAmbulatory blood pressure monitoringInterdialytic ambulatory blood pressure monitoringBlood pressure monitoringPost-HD valuesHD patientsPressure monitoringReproducibility of ABPMDrug regimenHemodialysis patientsHemodialysis practiceHD sessionNocturnal declineInterdialytic periodPatientsBP determinationRegimenPeriodSleepCoefficient of variation
1999
Delayed Gallium-67 uptake in renal atheroembolic disease
Peixoto A, Reilly R, Crowley S. Delayed Gallium-67 uptake in renal atheroembolic disease. American Journal Of Kidney Diseases 1999, 34: 161-165. PMID: 10401032, DOI: 10.1016/s0272-6386(99)70124-1.Peer-Reviewed Original ResearchConceptsAllergic interstitial nephritisAtheroembolic diseaseGallium scanRenal biopsyRenal atheroembolic diseaseAcute renal failureDefinitive histological diagnosisGallium-67 uptakeInterstitial nephritisRenal failureHistological diagnosisCase reportClinical challengeCorrect diagnosisGallium-67Nuclear imagingDiseaseBiopsyDiagnosisScansNephritisPresented reviewDiscriminating abilityGood discriminating abilityUptake