2019
Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling
Thorn SL, Barlow SC, Feher A, Stacy MR, Doviak H, Jacobs J, Zellars K, Renaud JM, Klein R, deKemp RA, Khakoo AY, Lee T, Spinale FG, Sinusas AJ. Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling. Circulation Cardiovascular Imaging 2019, 12: e009055. PMID: 31707811, PMCID: PMC7250243, DOI: 10.1161/circimaging.119.009055.Peer-Reviewed Original ResearchConceptsMyocardial blood flowSingle photon emissionBlood flowRecombinant TIMP-3Matrix metalloproteinasesR injuryTomography/Intracoronary deliveryMMP activationPost-myocardial infarction remodelingSubsequent left ventricular remodelingHybrid single-photon emissionDual-isotope single-photon emissionTomography/Computed Tomography ImagingLeft ventricular remodelingIschemia/reperfusionPost-MI remodelingPost-myocardial infarctionComputed tomography (CT) imagingIntracoronary infusionVentricular functionSaline groupVentricular remodelingNoninvasive evaluationTreatment groupsNoninvasive In Vivo Quantification of Adeno-Associated Virus Serotype 9–Mediated Expression of the Sodium/Iodide Symporter Under Hindlimb Ischemia and Neuraminidase Desialylation in Skeletal Muscle Using Single-Photon Emission Computed Tomography/Computed Tomography
Boutagy NE, Ravera S, Papademetris X, Onofrey JA, Zhuang ZW, Wu J, Feher A, Stacy MR, French BA, Annex BH, Carrasco N, Sinusas AJ. Noninvasive In Vivo Quantification of Adeno-Associated Virus Serotype 9–Mediated Expression of the Sodium/Iodide Symporter Under Hindlimb Ischemia and Neuraminidase Desialylation in Skeletal Muscle Using Single-Photon Emission Computed Tomography/Computed Tomography. Circulation Cardiovascular Imaging 2019, 12: e009063. PMID: 31296047, PMCID: PMC6629470, DOI: 10.1161/circimaging.119.009063.Peer-Reviewed Original ResearchConceptsMicro-single photon emissionSingle photon emissionHindlimb ischemiaTomography/Tomography/Computed TomographyIschemic gastrocnemius muscleNIS inhibitor perchloratePeripheral artery diseaseSkeletal muscleUnilateral hindlimb ischemiaAdeno-Associated Virus Serotype 9Standardized uptake valueSodium/iodide symporterVivo quantificationVirus serotype 9Vivo validationNonischemic limbsArtery diseaseNonischemic muscleC57BL/6J miceMurine modelGastrocnemius muscleComputed tomographyIschemic conditionsRadiotracer uptake
2013
Multimodality Imaging Approach for Serial Assessment of Regional Changes in Lower Extremity Arteriogenesis and Tissue Perfusion in a Porcine Model of Peripheral Arterial Disease
Stacy MR, Yu da Y, Maxfield MW, Jaba IM, Jozwik BP, Zhuang ZW, Lin BA, Hawley CL, Caracciolo CM, Pal P, Tirziu D, Sampath S, Sinusas AJ. Multimodality Imaging Approach for Serial Assessment of Regional Changes in Lower Extremity Arteriogenesis and Tissue Perfusion in a Porcine Model of Peripheral Arterial Disease. Circulation Cardiovascular Imaging 2013, 7: 92-99. PMID: 24170237, PMCID: PMC3929970, DOI: 10.1161/circimaging.113.000884.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArteriesCapillariesCollateral CirculationDisease Models, AnimalLower ExtremityMaleMultimodal ImagingNeovascularization, PhysiologicPerfusion ImagingPeripheral Arterial DiseasePredictive Value of TestsRegional Blood FlowReproducibility of ResultsSwineTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsPeripheral arterial diseaseSPECT/CT imagingArterial diseaseWeeks postocclusionProximal musclesCT imagingCapillary densityTissue perfusionPorcine modelLower extremity perfusionSingle photon emission tomographyFemoral artery occlusionMultimodality Imaging ApproachPhoton emission tomographyGamma countingIschemic calfNonischemic hindlimbsExtremity perfusionArtery occlusionLimb ischemiaMuscle perfusionSerial assessmentSerial changesCT angiographySPECT perfusion
1998
Experimental evaluation of radiotracers: Role of intact biological models
Sinusas A. Experimental evaluation of radiotracers: Role of intact biological models. Journal Of Nuclear Cardiology 1998, 5: 167-183. PMID: 9588669, DOI: 10.1016/s1071-3581(98)90200-8.Peer-Reviewed Original Research
1994
Intracoronary Ethanol Ablation in Swine:
HAINES D, VEROW A, SINUSAS A, WHAYNE J, DiMARCO J. Intracoronary Ethanol Ablation in Swine:. Journal Of Cardiovascular Electrophysiology 1994, 5: 41-49. PMID: 8186876, DOI: 10.1111/j.1540-8167.1994.tb01113.x.Peer-Reviewed Original ResearchConceptsIntracoronary ethanol ablationVentricular ejection fractionPerfusion bedAblation bedEjection fractionEthanol ablationChemical ablationLeft ventricular ejection fractionCoronary blood supplySignificant ventricular arrhythmiasCircumflex coronary arteryLeft anterior descendingTreatment of arrhythmiasDistribution of necrosisCoronary artery bedArterial pressureMethoxyisobutyl isonitrileSignificant arrhythmiasAnterior descendingIntracoronary infusionVentricular arrhythmiasCoronary arteryCoronary bedCoronary branchesHemodynamic parameters