2022
No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination
Lu-Culligan A, Tabachnikova A, Pérez-Then E, Tokuyama M, Lee HJ, Lucas C, Monteiro V, Miric M, Brache V, Cochon L, Muenker MC, Mohanty S, Huang J, Kang I, Dela Cruz C, Farhadian S, Campbell M, Yildirim I, Shaw AC, Ma S, Vermund SH, Ko AI, Omer SB, Iwasaki A. No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination. PLOS Biology 2022, 20: e3001506. PMID: 35609110, PMCID: PMC9129011, DOI: 10.1371/journal.pbio.3001506.Peer-Reviewed Original ResearchConceptsCOVID-19 mRNA vaccinationMRNA vaccinationEarly pregnancyFetal sizeCoronavirus disease 2019 (COVID-19) mRNA vaccinationSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Maternal antibody statusAdverse neonatal outcomesSyndrome coronavirus 2Birth defectsPolyinosinic-polycytidylic acidCrown-rump lengthGross birth defectsUnvaccinated adultsMaternal illnessNeonatal outcomesVaccinated adultsAntibody statusTLR3 agonistEarly immunizationMurine pregnancyAntibody inductionCoronavirus 2
2021
Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study
Ticona J, Nery N, Ladines-Lim JB, Gambrah C, Sacramento G, de Paula Freitas B, Bouzon J, Oliveira-Filho J, Borja A, Adhikarla H, Montoya M, Chin A, Wunder EA, Ballalai V, Vieira C, Belfort R, Almeida A, Reis MG, Harris E, Ko AI, Costa F. Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study. PLOS Neglected Tropical Diseases 2021, 15: e0009162. PMID: 33544730, PMCID: PMC7891708, DOI: 10.1371/journal.pntd.0009162.Peer-Reviewed Original ResearchConceptsPopulation attributable fractionZIKV exposureMonths of ageMild cognitive delayZika virus exposureZIKV-exposed childrenPopulation-based cohortCognitive delayDevelopmental alterationsMonoclonal antibody blockadeMonths of lifeGross birth defectsAppropriate control groupsProspective serosurveyCohort studyNeurodevelopmental outcomesAntibody blockadeNeurodevelopmental evaluationVirus exposureAttributable fractionBehavioral abnormalitiesControl groupRest of womenZika virusCohort