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Ala F Nassar, PhD

Senior Research Scientist
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Contact Info

Yale School of Medicine

600 west campus drive

West Haven, CT 06516

United States

About

Titles

Senior Research Scientist

Biography

Ala F. Nassar, PhD, is a faculty member at Yale University. He has over 25 years of experience in Drug Metabolism and Preclinical Drug Development with leadership roles in both big pharma, smaller biotech firms and academics (UCONN, Brandeis and Yale). He has published more than 100 articles and chapters and holds patents in the fields of drug metabolism and bioanalytical chemistry. He leads and executes ADME-Tox experiments supporting grant projects. He was the head of the drug metabolism and bioanalytical department at Vion Pharmaceuticals, where his studies of the ADME-Tox properties of Laromustine led to a fuller, more accurate and detailed understanding of the human toxicities of the drug. He was an Ass. Professor of chemistry department and the director of Mass Spectrometry Facility at Brandeis University in Waltham, MA before coming to Yale. He has served on numerous editorial boards and is the editor of the previous edition of Drug Metabolism Handbook: Concepts and Applications and Biotransformation and Metabolite Elucidation of Xenobiotics: Characterization and Identification. Co-editor of Pharmaceutical Sciences Encyclopedia: Drug Discovery, Development & Manufacturing, 2010. He was honored as a guest editor of the special issue of Metabolites entitled "MS-Based Drug Metabolism in Cancer Research. 2021"

Courses Taught and Coordinated

General chemistry 161 and 162, Central Connecticut State University, Spring 2017

Advanced Mass Spectrometry course at Brandeis University, Fall 2011

Coordinated and taught graduate-level course on drug metabolism and bioanalytical chemistry at University of Connecticut, 2003, 2005, 2007 and 2011

Liquid Chromatography-Mass Spectrometry at Cambridge Healthtech Institute’s World Pharmaceutical Congress Annual Meeting, Philadelphia, PA 2005 and 2007

Drug Metabolism at Cambridge Healthtech Institute’s World Pharmaceutical Congress Annual Meeting, Philadelphia, PA 2007 and 2008

Capillary Electrophoresis-Mass Spectrometry, at Battelle Memorial Institute, Columbus, OH 1998

Appointments

Departments & Organizations

Education & Training

Post Doc
UCONN/Chemistry/Pharmacology
PhD
UCONN, Bioanalytical/Drug Metabolism
Visiting Scientist
Kyushu and Nagasaki Universities

Research

Overview

Our research focuses on understanding how structure modification can improve the ADME-Tox profile for new chemical entities as they advance toward clinical candidacy. Our recent efforts use Mass Cytometry & MALDI-IHC as novel tools for Cancer Research. With their capacity for tremendous detail, these techniques produce enhanced investigative power for analyses involving simultaneous cellular profiling of multiple cell populations. Our latest endeavors are focused on an advance in single cell analysis using a hybrid mass spectrometry-flow cytometry instrument to identify and characterize rare cell types in clinical samples. Another emphasis is the development of mass spectrometric and proteomic methods for application in biological and clinical contexts to identify and quantify proteins with greater depth and coverage in a single cell.

Medical Subject Headings (MeSH)

Mass Spectrometry; Metabolism; Metabolomics; Pharmacology; Proteomics; Single-Cell Analysis

Research at a Glance

Yale Co-Authors

Frequent collaborators of Ala F Nassar's published research.

Publications

2024

2022

2021

Academic Achievements & Community Involvement

  • activity

    Journal of Drug Metabolism Letters

  • activity

    The American Society for Mass Spectrometry

  • activity

    CT Science Fair

  • activity

    Metabolites

  • activity

    Metabolites

Get In Touch

Contacts

Mailing Address

Yale School of Medicine

600 west campus drive

West Haven, CT 06516

United States

Supported Faculty