2017
TAM Receptors Are Not Required for Zika Virus Infection in Mice
Hastings AK, Yockey LJ, Jagger BW, Hwang J, Uraki R, Gaitsch HF, Parnell LA, Cao B, Mysorekar IU, Rothlin CV, Fikrig E, Diamond MS, Iwasaki A. TAM Receptors Are Not Required for Zika Virus Infection in Mice. Cell Reports 2017, 19: 558-568. PMID: 28423319, PMCID: PMC5485843, DOI: 10.1016/j.celrep.2017.03.058.Peer-Reviewed Original ResearchConceptsTAM receptorsZika virusAbsence of IFNARGlobal public health concernNon-pregnant miceZika virus infectionAdult female micePublic health concernZIKV entryZIKV infectionFemale miceViral inoculationZIKV replicationMertk (TAM) receptorsYoung miceVirus infectionEntry receptorViral titersViral replicationCell tropismInfectionHealth concernMiceAxlReceptors
2014
Poliomyelitis in transgenic mice expressing CD155 under the control of the Tage4 promoter after oral and parenteral poliovirus inoculation
Khan S, Toyoda H, Linehan M, Iwasaki A, Nomoto A, Bernhardt G, Cello J, Wimmer E. Poliomyelitis in transgenic mice expressing CD155 under the control of the Tage4 promoter after oral and parenteral poliovirus inoculation. Journal Of General Virology 2014, 95: 1668-1676. PMID: 24784416, PMCID: PMC4103066, DOI: 10.1099/vir.0.064535-0.Peer-Reviewed Original ResearchConceptsTg mouse modelPeyer's patchesOral routeGastrointestinal tractMouse modelTransgenic miceImmunocompetent transgenic mouseHuman PV receptorCD155 tg miceSurface of enterocytesTgPVR21 miceCD155 expressionParenteral inoculationTg miceIntracerebral inoculationOral infectionYoung miceGut infectionLymphatic tissueGerminal centersPV infectionPV replicationPV receptorSmall intestineHuman CD155