2016
Exploiting Mucosal Immunity for Antiviral Vaccines
Iwasaki A. Exploiting Mucosal Immunity for Antiviral Vaccines. Annual Review Of Immunology 2016, 34: 575-608. PMID: 27168245, DOI: 10.1146/annurev-immunol-032414-112315.Peer-Reviewed Original ResearchConceptsMucosal immunityHuman immunodeficiency virusEffective immune protectionHost immune responseHerpes simplex virusImmunodeficiency virusMucosal vaccinesImmune protectionSuccessful vaccineImmune responseSimplex virusAntiviral vaccinesMucosal surfacesVaccine developmentVaccine designInfluenza virusFirst lineVaccineViral pathogensImmunityViral diseasesVirusDangerous pathogensPathogensDisease
2011
Autophagy in the control and pathogenesis of viral infection
Yordy B, Iwasaki A. Autophagy in the control and pathogenesis of viral infection. Current Opinion In Virology 2011, 1: 196-203. PMID: 21927636, PMCID: PMC3171969, DOI: 10.1016/j.coviro.2011.05.016.Peer-Reviewed Original ResearchConceptsEukaryotic defense mechanismEukaryotic cell metabolismIntracellular pathogensVertebrate immune systemTime of starvationConstitutive autophagyCellular proteinsKey unanswered questionsCell metabolismAncient abilityAutophagyDefense mechanismsCell processesAntiviral immune responseRecent findingsPathogensCentral roleViral pathogensImmune systemOrganellesViral infectionMachineryUnanswered questionsImmune responseProtein
2010
Regulation of Adaptive Immunity by the Innate Immune System
Iwasaki A, Medzhitov R. Regulation of Adaptive Immunity by the Innate Immune System. Science 2010, 327: 291-295. PMID: 20075244, PMCID: PMC3645875, DOI: 10.1126/science.1183021.Peer-Reviewed Original ResearchConceptsInnate immune recognitionB lymphocyte-mediated immune responsesImmune responsePattern recognition receptorsImmune recognitionAntigen-specific adaptive immune responsesLymphocyte-mediated immune responsesMicrobial pathogensInnate immune systemAdaptive immune responsesRecognition receptorsHost defenseField of immunologyAdaptive immunityImmune systemFundamental questionsReceptorsRegulationPathwayPathogensInvasionDefenseInjuryInfectionDiscovery
2007
Mucosal Dendritic Cells
Iwasaki A. Mucosal Dendritic Cells. Annual Review Of Immunology 2007, 25: 381-418. PMID: 17378762, DOI: 10.1146/annurev.immunol.25.022106.141634.Peer-Reviewed Original ResearchConceptsMucosal dendritic cellsDendritic cellsMucosal surfacesSpecialized dendritic cellsRobust protective immunityAdaptive immune systemMucus-secreting cellsProtective immunityEnvironmental antigensMucosal barrierCommensal floraImmune systemEpithelial cellsRecognition of microorganismsAntigenAppropriate local responsesCellsVital functionsResponsePathogensAbsence of pathogensExcretionImmunity