2020
Method for Measuring Mucociliary Clearance and Cilia-generated Flow in Mice by ex vivo Imaging.
Song E, Iwasaki A. Method for Measuring Mucociliary Clearance and Cilia-generated Flow in Mice by ex vivo Imaging. Bio-protocol 2020, 10: e3554. PMID: 33659527, PMCID: PMC7842288, DOI: 10.21769/bioprotoc.3554.Peer-Reviewed Original Research
2019
Low ambient humidity impairs barrier function and innate resistance against influenza infection
Kudo E, Song E, Yockey LJ, Rakib T, Wong PW, Homer RJ, Iwasaki A. Low ambient humidity impairs barrier function and innate resistance against influenza infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 10905-10910. PMID: 31085641, PMCID: PMC6561219, DOI: 10.1073/pnas.1902840116.Peer-Reviewed Original ResearchConceptsInfluenza infectionImpair barrier functionImpairs host defenseSeasonal influenza virusesInfluenza virus infectionLungs of miceImpairs mucociliary clearanceTissue repairInduction of IFNInnate antiviral defenseViral burdenMucociliary clearanceDisease outcomeRespiratory challengeVirus infectionSevere diseaseViral infectionCongenic miceHost responseViral transmissionHost defenseSingle-cell RNA sequencingInnate resistanceDisease pathologyInfluenza virus