2022
High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells
Chen JS, Chow RD, Song E, Mao T, Israelow B, Kamath K, Bozekowski J, Haynes WA, Filler RB, Menasche BL, Wei J, Alfajaro MM, Song W, Peng L, Carter L, Weinstein JS, Gowthaman U, Chen S, Craft J, Shon JC, Iwasaki A, Wilen CB, Eisenbarth SC. High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells. Science Immunology 2022, 7: eabl5652. PMID: 34914544, PMCID: PMC8977051, DOI: 10.1126/sciimmunol.abl5652.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionSARS-CoV-2Follicular helper cellsB cell responsesHelper cellsAntibody productionCell responsesSARS-CoV-2 vaccinationB-cell receptor sequencingSevere COVID-19Cell receptor sequencingIndependent antibodiesT cell-B cell interactionsViral inflammationAntiviral antibodiesImmunoglobulin class switchingVirus infectionGerminal centersViral infectionClonal repertoireInfectionAntibodiesClass switchingCOVID-19Patients
2014
Poliomyelitis in transgenic mice expressing CD155 under the control of the Tage4 promoter after oral and parenteral poliovirus inoculation
Khan S, Toyoda H, Linehan M, Iwasaki A, Nomoto A, Bernhardt G, Cello J, Wimmer E. Poliomyelitis in transgenic mice expressing CD155 under the control of the Tage4 promoter after oral and parenteral poliovirus inoculation. Journal Of General Virology 2014, 95: 1668-1676. PMID: 24784416, PMCID: PMC4103066, DOI: 10.1099/vir.0.064535-0.Peer-Reviewed Original ResearchConceptsTg mouse modelPeyer's patchesOral routeGastrointestinal tractMouse modelTransgenic miceImmunocompetent transgenic mouseHuman PV receptorCD155 tg miceSurface of enterocytesTgPVR21 miceCD155 expressionParenteral inoculationTg miceIntracerebral inoculationOral infectionYoung miceGut infectionLymphatic tissueGerminal centersPV infectionPV replicationPV receptorSmall intestineHuman CD155
2002
Immunofluorescence Analysis of Poliovirus Receptor Expression in Peyer’s Patches of Humans, Primates, and CD155 Transgenic Mice: Implications for Poliovirus Infection
Iwasaki A, Welker R, Mueller S, Linehan M, Nomoto A, Wimmer E. Immunofluorescence Analysis of Poliovirus Receptor Expression in Peyer’s Patches of Humans, Primates, and CD155 Transgenic Mice: Implications for Poliovirus Infection. The Journal Of Infectious Diseases 2002, 186: 585-592. PMID: 12195344, DOI: 10.1086/342682.Peer-Reviewed Original ResearchConceptsFollicle-associated epitheliumPeyer's patchesCD155 expressionGerminal centersPoliovirus infectionGastrointestinal-associated lymphoid tissueIntestinal epitheliumPoliovirus receptor (PVR) expressionExpression of CD155Human poliovirus receptorCD155 tg miceCertain primate speciesTg miceLymphoid tissueOral infectionReceptor expressionMicrofold cellsTransgenic miceTunica muscularisCD155 transgenic micePoliovirus receptorRhesus macaquesInfectionM cellsEpithelium