2004
Involvement of Dendritic Cell Subsets in the Induction of Oral Tolerance and Immunity
FLEETON M, CONTRACTOR N, LEON F, HE J, WETZEL D, DERMODY T, IWASAKI A, KELSALL B. Involvement of Dendritic Cell Subsets in the Induction of Oral Tolerance and Immunity. Annals Of The New York Academy Of Sciences 2004, 1029: 60-65. PMID: 15681744, DOI: 10.1196/annals.1309.008.Peer-Reviewed Original ResearchConceptsSubepithelial dome regionDendritic cellsApoptotic epithelial cellsDC maturationEpithelial cellsOral administrationT cellsImmune responsePP follicle-associated epitheliumSystemic antiviral immune responsesDendritic cell subsetsPlasmacytoid dendritic cellsCross-present antigensRegulatory T cellsInduction of immunityB cell responsesAntiviral immune responseActive viral infectionFollicle-associated epitheliumMurine Peyer's patchesDC infectionDC subsetsOral antigenDC populationsOral tolerance
2003
CCL9 Is Secreted by the Follicle-Associated Epithelium and Recruits Dome Region Peyer’s Patch CD11b+ Dendritic Cells
Zhao X, Sato A, Dela Cruz CS, Linehan M, Luegering A, Kucharzik T, Shirakawa AK, Marquez G, Farber JM, Williams I, Iwasaki A. CCL9 Is Secreted by the Follicle-Associated Epithelium and Recruits Dome Region Peyer’s Patch CD11b+ Dendritic Cells. The Journal Of Immunology 2003, 171: 2797-2803. PMID: 12960300, DOI: 10.4049/jimmunol.171.6.2797.Peer-Reviewed Original ResearchConceptsFollicle-associated epitheliumCCR6-deficient miceSubepithelial dome regionDendritic cellsPeyer's patchesMouse Peyer's patchesCCR6-/- miceDC recruitmentChemokine CCL20DC numbersAb neutralizationCCL9Villus epitheliumCCL20RT-PCRChemotaxis assaysProtein levelsMiceEpitheliumCCR6Vivo distributionImmunofluorescence analysisChemokinesSignificant reductionPutative receptor
2002
Immunofluorescence Analysis of Poliovirus Receptor Expression in Peyer’s Patches of Humans, Primates, and CD155 Transgenic Mice: Implications for Poliovirus Infection
Iwasaki A, Welker R, Mueller S, Linehan M, Nomoto A, Wimmer E. Immunofluorescence Analysis of Poliovirus Receptor Expression in Peyer’s Patches of Humans, Primates, and CD155 Transgenic Mice: Implications for Poliovirus Infection. The Journal Of Infectious Diseases 2002, 186: 585-592. PMID: 12195344, DOI: 10.1086/342682.Peer-Reviewed Original ResearchConceptsFollicle-associated epitheliumPeyer's patchesCD155 expressionGerminal centersPoliovirus infectionGastrointestinal-associated lymphoid tissueIntestinal epitheliumPoliovirus receptor (PVR) expressionExpression of CD155Human poliovirus receptorCD155 tg miceCertain primate speciesTg miceLymphoid tissueOral infectionReceptor expressionMicrofold cellsTransgenic miceTunica muscularisCD155 transgenic micePoliovirus receptorRhesus macaquesInfectionM cellsEpithelium
2001
Unique Functions of CD11b+, CD8α+, and Double-Negative Peyer’s Patch Dendritic Cells
Iwasaki A, Kelsall B. Unique Functions of CD11b+, CD8α+, and Double-Negative Peyer’s Patch Dendritic Cells. The Journal Of Immunology 2001, 166: 4884-4890. PMID: 11290765, DOI: 10.4049/jimmunol.166.8.4884.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDB7-1 AntigenB7-2 AntigenCD8 AntigensCell LineageCell SeparationDendritic CellsEpithelial CellsEpitopes, T-LymphocyteFemaleHistocompatibility Antigens Class IIImmunophenotypingInterferon-gammaInterleukin-10Interleukin-12Interleukin-4Lectins, C-TypeLymphocyte ActivationLymphocyte SubsetsMacrophage-1 AntigenMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicMinor Histocompatibility AntigensMyeloid CellsPeyer's PatchesReceptors, Cell SurfaceSpleenT-LymphocytesUp-RegulationConceptsMyeloid dendritic cellsDendritic cellsCD40 ligand trimerDC subsetsIL-12p70IL-10T cellsPeyer's patch dendritic cellsIFN-gamma productionSoluble CD40 ligand trimerMucosal lymphoid tissuesNaive T cellsFollicle-associated epitheliumMurine Peyer's patchesNonmucosal sitesDC subpopulationsSubepithelial domeIL-4Lymphoid tissuePeyer's patchesMicrobial stimuliInterfollicular regionsIFN-gammaSurface phenotypeMucosal tissues
2000
Localization of Distinct Peyer's Patch Dendritic Cell Subsets and Their Recruitment by Chemokines Macrophage Inflammatory Protein (Mip)-3α, Mip-3β, and Secondary Lymphoid Organ Chemokine
Iwasaki A, Kelsall B. Localization of Distinct Peyer's Patch Dendritic Cell Subsets and Their Recruitment by Chemokines Macrophage Inflammatory Protein (Mip)-3α, Mip-3β, and Secondary Lymphoid Organ Chemokine. Journal Of Experimental Medicine 2000, 191: 1381-1394. PMID: 10770804, PMCID: PMC2193144, DOI: 10.1084/jem.191.8.1381.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceChemokine CCL19Chemokine CCL20Chemokines, CCChemotaxisDendritic CellsDNA PrimersFemaleGene ExpressionIn Situ HybridizationMacrophage Inflammatory ProteinsMiceMice, Inbred BALB CMicroscopy, ConfocalModels, BiologicalPeyer's PatchesReceptors, CCR6Receptors, CCR7Receptors, ChemokineRNA, MessengerSpleenConceptsDendritic cell subsetsInterfollicular regionsDC subsetsCell subsetsInflammatory proteinPeyer's patchesSecondary lymphoid organ chemokineChemokine macrophage inflammatory proteinSplenic DC subsetsSubepithelial dome regionDistinct dendritic cell subsetsRole of chemokinesT cell responsesMacrophage inflammatory proteinT-cell regionsFollicle-associated epitheliumMurine Peyer's patchesTranscriptase-polymerase chain reaction analysisFunctional CCR7Lymphoid DCsMIP-3βPP DCsMyeloid DCsCCR7 expressionPolymerase chain reaction analysis