2023
Is psychiatric diagnostic remission associated with reduced prevalence of moderate to severe pain interference and improved functioning among adults with lifetime psychiatric disorders?
Manhapra A, Zhou B, Rhee T, Rosenheck R. Is psychiatric diagnostic remission associated with reduced prevalence of moderate to severe pain interference and improved functioning among adults with lifetime psychiatric disorders? Journal Of Affective Disorders 2023, 344: 585-591. PMID: 37863364, DOI: 10.1016/j.jad.2023.10.094.Peer-Reviewed Original ResearchConceptsLifetime psychiatric disordersPast-year psychiatric disordersSevere pain interferencePain interferencePsychiatric disordersPD remissionChronic painNon-substance use psychiatric disordersPrevalence of painMental functioningLower physical functioningNational Epidemiologic SurveyRelated Conditions-IIIPoor mental functioningCommon comorbiditiesPhysical functionAdjusted oddsPhysical functioningObservational studyReduced prevalenceRemissionUS adultsDiagnostic remissionEpidemiologic SurveyPainMonotonic Association of Increasing Past-Year Substance Use Disorder across a Four-Level Trauma Post-Traumatic Stress Disorder (PTSD) Hierarchy in a Nationwide Sample
Jegede O, Manhapra A, Zhou B, Rhee T, Rosenheck R. Monotonic Association of Increasing Past-Year Substance Use Disorder across a Four-Level Trauma Post-Traumatic Stress Disorder (PTSD) Hierarchy in a Nationwide Sample. Journal Of Dual Diagnosis 2023, 19: 231-239. PMID: 37796996, DOI: 10.1080/15504263.2023.2260339.Peer-Reviewed Original ResearchConceptsSubstance use disordersTrauma exposureCurrent PTSDUse disordersComparison of adultPast-year substance use disorderSUD prevalencePTSDRelated Conditions Wave IIINational Epidemiologic SurveyTrauma groupNationwide sampleDifferential effectsGreater likelihoodSUD diagnosisUnadjusted resultsClinical consequencesHierarchical groupsEpidemiologic SurveyWave IIIAdultsDisordersMonotonic associationPrior groupPrevalence
2022
Persistence of significant pain interference following substance use disorder remission: Negative association with psychosocial and physical recovery
Manhapra A, Stefanovics EA, Rhee TG, Rosenheck RA. Persistence of significant pain interference following substance use disorder remission: Negative association with psychosocial and physical recovery. Drug And Alcohol Dependence 2022, 232: 109339. PMID: 35121202, DOI: 10.1016/j.drugalcdep.2022.109339.Peer-Reviewed Original ResearchConceptsSubstance use disordersPast-year substance use disorderSevere pain interferencePain interferenceIndependent associationSUD remissionActive substance use disorderSignificant pain interferenceIndependent negative associationRelated Conditions Wave IIINegative associationPositive independent associationStrong negative associationUnited States adultsNational Epidemiologic SurveyPersistent painPhysical functionRemissionUS adultsUse disordersDisorder remissionEpidemiologic SurveyWave IIIClinical attentionStates adults
2021
Who Uses Veterans Mental Health Services?
Manhapra A, Stefanovics EA, Rhee TG, Rosenheck RA. Who Uses Veterans Mental Health Services? The Journal Of Nervous And Mental Disease 2021, 209: 702-709. PMID: 33993183, DOI: 10.1097/nmd.0000000000001369.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationPosttraumatic stress disorderHealth service usersMH service usersSubstance use disorder diagnosisClinical practice guidelinesMental health servicesMental health service usersClinical characteristicsMedicaid insurancePain interferenceService usersBlack raceSimilar prevalenceMental health researchMH researchPractice guidelinesGreater prevalenceHealth AdministrationHealth servicesPTSD diagnosisRacial distributionMH statusStress disorderDisorder diagnosis
2020
Association of symptom severity, pain and other behavioral and medical comorbidities with diverse measures of functioning among adults with post-traumatic stress disorder
Manhapra A, Stefanovics EA, Rhee TG, Rosenheck RA. Association of symptom severity, pain and other behavioral and medical comorbidities with diverse measures of functioning among adults with post-traumatic stress disorder. Journal Of Psychiatric Research 2020, 134: 113-120. PMID: 33383494, DOI: 10.1016/j.jpsychires.2020.12.063.Peer-Reviewed Original ResearchConceptsMental health composite scoresPhysical function scoresPost-traumatic stress disorderSubstance use disordersMedical comorbiditiesPain interferencePTSD symptomsStatistical Manual-5 (DSM-5) criteriaSymptom severityMental health-related qualityStress disorderPast-year post-traumatic stress disorderShort Form-12Health-related qualityNational Epidemiologic SurveyNegative associationCommon comorbiditiesChronic painForm-12Medical illnessSubstantial disabilityPsychiatric comorbidityPTSD symptom severityFunction scoresIndependent associationComplex Persistent Opioid Dependence with Long-term Opioids: a Gray Area That Needs Definition, Better Understanding, Treatment Guidance, and Policy Changes
Manhapra A, Sullivan MD, Ballantyne JC, MacLean RR, Becker WC. Complex Persistent Opioid Dependence with Long-term Opioids: a Gray Area That Needs Definition, Better Understanding, Treatment Guidance, and Policy Changes. Journal Of General Internal Medicine 2020, 35: 964-971. PMID: 33159241, PMCID: PMC7728942, DOI: 10.1007/s11606-020-06251-w.Peer-Reviewed Original ResearchConceptsLong-term opioid therapyOpioid taperingOpioid dependenceChronic pain refractoryUtilization of buprenorphineLong-term opioidsSevere chronic painOpioid use disorderMultitude of treatmentsLimited supportive evidenceOpioid therapyPain refractoryBuprenorphine treatmentChronic painClinical instabilityRecent guidelinesClinical definitionUS adultsUse disordersDiagnosis/Treatment guidancePainComplicationsTreatmentSupportive evidenceAll-cause mortality among males living with and without HIV initiating long-term opioid therapy, and its association with opioid dose, opioid interruption and other factors
Gordon K, Manhapra A, Crystal S, Dziura J, Edelman E, Skanderson M, Kerns R, Justice A, Tate J, Becker W. All-cause mortality among males living with and without HIV initiating long-term opioid therapy, and its association with opioid dose, opioid interruption and other factors. Drug And Alcohol Dependence 2020, 216: 108291. PMID: 33011662, PMCID: PMC7644145, DOI: 10.1016/j.drugalcdep.2020.108291.Peer-Reviewed Original ResearchConceptsMorphine equivalent daily doseCause mortalityLong-term opioid therapyTime-updated Cox regressionStrong dose-response relationshipUnnatural deathsEquivalent daily doseDose-response relationshipOpioid doseOpioid therapyUninfected patientsOpioid useDaily doseCox regressionMortality outcomesTherapy doseHigh doseMale veteransOverdose fatalitiesOverdose mortalityPLWHMortalityHIVPatientsDoseAssociations between stopping prescriptions for opioids, length of opioid treatment, and overdose or suicide deaths in US veterans: observational evaluation
Oliva E, Bowe T, Manhapra A, Kertesz S, Hah J, Henderson P, Robinson A, Paik M, Sandbrink F, Gordon A, Trafton J. Associations between stopping prescriptions for opioids, length of opioid treatment, and overdose or suicide deaths in US veterans: observational evaluation. The BMJ 2020, 368: m283. PMID: 32131996, PMCID: PMC7249243, DOI: 10.1136/bmj.m283.Peer-Reviewed Original ResearchConceptsLength of treatmentVeterans Health AdministrationOpioid treatmentHealth AdministrationLong patientsObservational evaluationRisk of deathHazards regression modelsFocus of guidelinesLong-term useOpioid cessationOpioid prescriptionsOpioid analgesicsOutpatient prescriptionsPlace patientsSafe prescribingPatient deathUS veteransNon-proportional hazards regression modelsPatient's perspectiveFiscal year 2014OpioidsPatientsOverdoseGreater risk
2019
High-dose prescribed opioids are associated with increased risk of heroin use among United States military veterans.
Banerjee G, Edelman EJ, Barry DT, Crystal S, Gordon KS, Gordon AJ, Gaither JR, Green TC, Kerns RD, Manhapra A, Moore BA, Fiellin DA, Marshall BDL. High-dose prescribed opioids are associated with increased risk of heroin use among United States military veterans. Pain 2019, 160: 2126-2135. PMID: 31145217, PMCID: PMC6699915, DOI: 10.1097/j.pain.0000000000001606.Peer-Reviewed Original ResearchConceptsHigh-dose opioid prescriptionsOpioid prescriptionsHeroin useCohort studyPrior receiptHepatitis C virus (HCV) infection statusLong-term opioid prescriptionsPast-year heroin useVeterans Aging Cohort StudyHigh-dose opioidsOpioid-prescribing patternsProspective cohort studyAging Cohort StudyOpioid use disorderCurrent national guidelinesUnhealthy alcohol useUnited States veteransUnited States military veteransVirus infection statusPosttraumatic stress disorderOpioid receiptPrescribed opioidsPain interferenceCox regressionStates veterans
2017
Three‐year retention in buprenorphine treatment for opioid use disorder nationally in the Veterans Health Administration
Manhapra A, Petrakis I, Rosenheck R. Three‐year retention in buprenorphine treatment for opioid use disorder nationally in the Veterans Health Administration. American Journal On Addictions 2017, 26: 572-580. PMID: 28472543, DOI: 10.1111/ajad.12553.Peer-Reviewed Original ResearchConceptsOpioid use disorderBuprenorphine treatmentLast prescriptionHazards modelUse disordersVeterans Health Administration facilitiesCox proportional hazards modelThree-year retentionProportion hazard modelKaplan-Meier curvesEmergency room visitsPsychotropic drug useVeterans Health AdministrationProportional hazards modelOnly black raceBuprenorphine discontinuationBuprenorphine retentionCharlson indexFirst prescriptionTreatment continuationRoom visitsBlack raceFY 2012Mean durationFiscal year 2012
2013
Early accelerated senescence of circulating endothelial progenitor cells in premature coronary artery disease patients in a developing country - a case control study
Vemparala K, Roy A, Bahl V, Prabhakaran D, Nath N, Sinha S, Nandi P, Pandey R, Reddy K, Manhapra A, Lakshmy R. Early accelerated senescence of circulating endothelial progenitor cells in premature coronary artery disease patients in a developing country - a case control study. BMC Cardiovascular Disorders 2013, 13: 104. PMID: 24245738, PMCID: PMC3871012, DOI: 10.1186/1471-2261-13-104.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseEndothelial progenitor cellsPCAD patientsVascular cell senescencePremature CADVascular senescenceEvidence of CADPremature coronary artery disease patientsNumber of EPCsCoronary artery disease patientsPremature coronary artery diseaseProgenitor cellsCase-control studyCell senescenceYears of ageReal-time polymerase chain reactionTime polymerase chain reactionCAD epidemicEPC senescenceYounger patientsArtery diseaseDisease patientsPolymerase chain reactionRandom patientsIndia Institute
2007
Differences in the prevalence of metabolic syndrome in urban and rural India: a problem of urbanization
Prabhakaran D, Chaturvedi V, Shah P, Manhapra A, Jeemon P, Shah B, Srinath Reddy K. Differences in the prevalence of metabolic syndrome in urban and rural India: a problem of urbanization. Chronic Illness 2007, 3: 8-19. PMID: 18072694, DOI: 10.1177/1742395307079197.Peer-Reviewed Original Research
2005
Cardiovascular risk factor prevalence among men in a large industry of northern India.
Prabhakaran D, Shah P, Chaturvedi V, Ramakrishnan L, Manhapra A, Reddy K. Cardiovascular risk factor prevalence among men in a large industry of northern India. The National Medical Journal Of India 2005, 18: 59-65. PMID: 15981439.Peer-Reviewed Original ResearchConceptsCVD risk factorsCoronary heart diseaseRisk factorsCardiovascular diseaseMetabolic syndromeHeart diseaseCardiovascular risk factor prevalenceMajor CVD risk factorsPrevalence of CVDLarge industrial populationRisk factor burdenCardiovascular risk profileHistory of strokeImpaired glucose toleranceRose angina questionnaireRisk factor prevalenceYoung male populationYears of ageCross-sectional surveyStatus of awarenessHypertension 30Angina QuestionnaireCentral obesityBlood pressureFactor prevalence
2000
Electrocardiographic presentation of blacks with first myocardial infarction does not explain race differences in thrombolysis administration
Manhapra A, Khaja F, Syed M, Rybicki B, Wulbrecht N, Alam M, Sabbah H, Goldstein S, Borzak S. Electrocardiographic presentation of blacks with first myocardial infarction does not explain race differences in thrombolysis administration. American Heart Journal 2000, 140: 200-205. PMID: 10925330, DOI: 10.1067/mhj.2000.107173.Peer-Reviewed Original ResearchConceptsElectrocardiographic presentationThrombolysis administrationFirst myocardial infarctionBundle branch blockConditional logistic regressionST-segment deviationFirst MIInitial electrocardiogramConsecutive patientsClinical presentationClinical variablesMyocardial infarctionBranch blockThrombolysisGreater prevalenceElectrocardiographic manifestationsLogistic regressionMyocardial infarction (MI) accountUnmeasured differencesRacial differencesSimilar proportionsFurther studiesEligibilityAdministrationPresentation