2019
Dilysine-Methylene Diphenyl Diisocyanate (MDI), a Urine Biomarker of MDI Exposure?
Wisnewski AV, Nassar AF, Liu J, Bello D. Dilysine-Methylene Diphenyl Diisocyanate (MDI), a Urine Biomarker of MDI Exposure? Chemical Research In Toxicology 2019, 32: 557-565. PMID: 30724074, PMCID: PMC6465083, DOI: 10.1021/acs.chemrestox.8b00262.Peer-Reviewed Original ResearchConceptsRespiratory tract exposureMDI exposureUrine biomarkersSkin exposureUrine of miceFuture translational investigationsWestern blot studiesUrinary biomarkersRespiratory tractExposure surveillanceTranslational investigationsDisease preventionMDI conjugatesMiceUrineBiomarkersCollision-induced dissociation (CID) fragmentation patternsExposureUnderstanding pathwaysMDIIndustrial hygieneAlbuminMS/MSTractPrevention
2003
Recent developments in diisocyanate asthma
Liu Q, Wisnewski AV. Recent developments in diisocyanate asthma. Annals Of Allergy Asthma & Immunology 2003, 90: 35-41. PMID: 12772950, DOI: 10.1016/s1081-1206(10)61647-x.Peer-Reviewed Original ResearchConceptsDiisocyanate asthmaPotential long-term adverse effectsMajor histocompatibility complex class II allelesLong-term adverse effectsGlutathione S-transferase polymorphismsImmune-dependent mechanismsAntigen-independent mechanismsLong-term followGenetic factorsHuman immune responseClass II allelesEffective diagnostic testAllergic asthmaAsthma patientsAtopic asthmaDiisocyanate exposureSymptomatic patientsImmune basisSensitized patientsAsthma pathogenesisPrognostic valueImmunologic differencesAirway epitheliumImmune responseAsthma
2001
Recent developments in diisocyanate asthma
Wisnewski A, Redlich C. Recent developments in diisocyanate asthma. Current Opinion In Allergy And Clinical Immunology 2001, 1: 169. PMID: 11964686, DOI: 10.1097/00130832-200104000-00009.Peer-Reviewed Original Research
2000
Identification of Human Lung and Skin Proteins Conjugated with Hexamethylene DiisocyanateIn Vitro and In Vivo
WISNEWSKI A, SRIVASTAVA R, HERICK C, XU L, LEMUS R, CAIN H, MAGOSKI N, KAROL M, BOTTOMLY K, REDLICH C. Identification of Human Lung and Skin Proteins Conjugated with Hexamethylene DiisocyanateIn Vitro and In Vivo. American Journal Of Respiratory And Critical Care Medicine 2000, 162: 2330-2336. PMID: 11112159, DOI: 10.1164/ajrccm.162.6.2002086.Peer-Reviewed Original ResearchConceptsDiisocyanate-induced asthmaBiopsy samplesHuman lungHuman airway epithelial cellsBronchoalveolar lavage fluidAirway epithelial cellsEndobronchial biopsy samplesHuman skin biopsy samplesSkin biopsy samplesKeratin 18Epicutaneous exposureLavage fluidSkin proteinsVivo inhalationVivo exposureEpithelial cell proteinsGlucose-regulated proteinEpithelial cellsAsthmaLungExposureVitroVivoKeratinCell proteins