2012
Biomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based on Serum Levels of HDI-Specific IgG
Wisnewski AV, Stowe MH, Nerlinger A, Opare-addo P, Decamp D, Kleinsmith CR, Redlich CA. Biomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based on Serum Levels of HDI-Specific IgG. Annals Of Work Exposures And Health 2012, 56: 901-910. PMID: 22449630, PMCID: PMC3471419, DOI: 10.1093/annhyg/mes024.Peer-Reviewed Original ResearchConceptsPersonal protective equipmentSkin exposureExposure surveillanceSpecific serum immunoglobulin GHexamethylene diisocyanate exposureSerum IgG levelsSerum immunoglobulin GNight shift workEnzyme-linked immunosorbentAdverse health effectsAsthma historyDiisocyanate exposureIgG levelsSerum levelsIgG titersChemical allergensPPE useImmune responseRespirator useIsocyanate exposureExposure biomarkersPractical biomarkersBasic demographicsHigh titersHygiene efforts
2003
Recent developments in diisocyanate asthma
Liu Q, Wisnewski AV. Recent developments in diisocyanate asthma. Annals Of Allergy Asthma & Immunology 2003, 90: 35-41. PMID: 12772950, DOI: 10.1016/s1081-1206(10)61647-x.Peer-Reviewed Original ResearchConceptsDiisocyanate asthmaPotential long-term adverse effectsMajor histocompatibility complex class II allelesLong-term adverse effectsGlutathione S-transferase polymorphismsImmune-dependent mechanismsAntigen-independent mechanismsLong-term followGenetic factorsHuman immune responseClass II allelesEffective diagnostic testAllergic asthmaAsthma patientsAtopic asthmaDiisocyanate exposureSymptomatic patientsImmune basisSensitized patientsAsthma pathogenesisPrognostic valueImmunologic differencesAirway epitheliumImmune responseAsthma
2002
Diisocyanate‐exposed auto body shop workers: A one‐year follow‐up
Redlich CA, Stowe MH, Coren BA, Wisnewski AV, Holm CT, Cullen MR. Diisocyanate‐exposed auto body shop workers: A one‐year follow‐up. American Journal Of Industrial Medicine 2002, 42: 511-518. PMID: 12439874, DOI: 10.1002/ajim.10143.Peer-Reviewed Original ResearchConceptsHealthy worker effectAuto body shop workersWorker effectHexamethylene diisocyanate exposureHistory of asthmaLower asthma prevalenceCross-sectional studyDiisocyanate exposureOccupational asthmaAsthma prevalenceImmunologic responseLow prevalenceAsthmaOne-yearHigh job turnover ratesShop workersEpisodic exposureSignificant differencesAuto body shopsPrevalenceEffect of HDISignificant changesExposureSymptomsIgG
2001
Subclinical immunologic and physiologic responses in hexamethylene diisocyanate‐exposed auto body shop workers
Redlich C, Stowe M, Wisnewski A, Eisen E, Karol M, Lemus R, Holm C, Chung J, Sparer J, Liu Y, Woskie S, Appiah‐Pippim J, Gore R, Cullen M. Subclinical immunologic and physiologic responses in hexamethylene diisocyanate‐exposed auto body shop workers. American Journal Of Industrial Medicine 2001, 39: 587-597. PMID: 11385643, DOI: 10.1002/ajim.1058.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAir Pollutants, OccupationalAnalysis of VarianceAsthmaAutomobilesChi-Square DistributionCross-Sectional StudiesCyanatesEpidemiologic StudiesFemaleHumansIsocyanatesMaleMiddle AgedOccupational DiseasesOccupational ExposurePaintStatistics, NonparametricSurveys and QuestionnairesConceptsAuto body shop workersDiisocyanate asthmaLymphocyte proliferationHost risk factorsShortness of breathShop workersMethacholine responsivenessMethacholine challengeChest tightnessDiisocyanate exposureOccupational asthmaImmunologic responseRisk factorsPhysiologic changesImmune responseEpidemiologic studiesSurveillance studyPhysiologic responsesAsthmaOvert casesSymptomsExposure dataEpisodic exposureAuto body shopsExposure