2024
Recent trends in GLP-1 RA and SGLT2i use among people with type 2 diabetes and atherosclerotic cardiovascular disease in the USA
King A, Tan X, Dhopeshwarkar N, Bohn R, Dea K, Leonard C, de Havenon A. Recent trends in GLP-1 RA and SGLT2i use among people with type 2 diabetes and atherosclerotic cardiovascular disease in the USA. BMJ Open Diabetes Research & Care 2024, 12: e004431. PMID: 39366717, PMCID: PMC11459310, DOI: 10.1136/bmjdrc-2024-004431.Peer-Reviewed Original ResearchConceptsSodium-glucose cotransporter 2 inhibitorsGLP-1 RAsAtherosclerotic cardiovascular diseaseGLP-1Type 2 diabetesIncident useGlucagon-like peptide-1 receptor agonistsPeptide-1 receptor agonistsCardiovascular diseasePrevalence of atherosclerotic cardiovascular diseaseASCVD diagnosisProportion of patientsRetrospective observational studyNested cohort studyReceptor agonistsSGLT2i useAnalysis of cross-sectional dataSodium-glucoseCohort studyPatient numbersObservational studyPatientsPrevalent useCross-sectional dataT2D
2023
Understanding Patterns of Missingness in Acute Ischemic Stroke Trials: A Secondary Analysis of Pooled Participant-Level Follow-Up Data
de Havenon A, Bangad A, Skolarus L, Aldridge C, Braun R, Cole J, Cramer S, Lindgren A, Sunmonu N, Worrall B, Lohse K. Understanding Patterns of Missingness in Acute Ischemic Stroke Trials: A Secondary Analysis of Pooled Participant-Level Follow-Up Data. Stroke 2023, 54: e201-e202. PMID: 36896708, PMCID: PMC10133020, DOI: 10.1161/strokeaha.122.042168.Peer-Reviewed Original Research
2021
Midlife Blood Pressure Variability and Risk of All-Cause Mortality and Cardiovascular Events During Extended Follow-up
de Havenon A, Delic A, Yaghi S, Wong KH, Majersik JJ, Stulberg E, Tirschwell D, Anadani M. Midlife Blood Pressure Variability and Risk of All-Cause Mortality and Cardiovascular Events During Extended Follow-up. American Journal Of Hypertension 2021, 34: 1269-1275. PMID: 34240111, PMCID: PMC8643578, DOI: 10.1093/ajh/hpab106.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureBlood Pressure DeterminationCardiovascular DiseasesFollow-Up StudiesHumansHypertensionMyocardial InfarctionRisk FactorsConceptsBlood pressure variabilityLong-term blood pressure variabilityCardiovascular eventsHazard ratioPressure variabilityCardiovascular disease-free participantsMean systolic blood pressureVisit blood pressure variabilityCox proportional hazards modelCardiovascular risk factorsCorresponding hazard ratiosCongestive heart failureDisease-free patientsSystolic blood pressureDisease-free participantsProportional hazards modelPrior strokeCause mortalitySecondary outcomesBlood pressureHeart failureIndependent predictorsPrimary outcomeVisit 4Mean agePredicting 90-Day Outcome After Thrombectomy: Baseline-Adjusted 24-Hour NIHSS Is More Powerful Than NIHSS Score Change
Mistry EA, Yeatts S, de Havenon A, Mehta T, Arora N, La Rosa F, Starosciak AK, Siegler JE, Mistry AM, Yaghi S, Khatri P. Predicting 90-Day Outcome After Thrombectomy: Baseline-Adjusted 24-Hour NIHSS Is More Powerful Than NIHSS Score Change. Stroke 2021, 52: 2547-2553. PMID: 34000830, PMCID: PMC11261999, DOI: 10.1161/strokeaha.120.032487.Peer-Reviewed Original ResearchConceptsNIHSS scoreLong-term functional outcomeNIHSS score changeComprehensive stroke centerHealth Stroke ScaleProspective observational studyEarly time pointsStroke centersStroke ScaleEndovascular therapyMRS outcomesMRS scoreRankin ScaleStroke patientsFunctional outcomeSurrogate markerClinical studiesNIHSSMultivariable modelingObservational studyOutcome measuresPatientsPercent changeScore changeLogistic regressionCarotid Stenosis and Recurrent Ischemic Stroke
Yaghi S, de Havenon A, Rostanski S, Kvernland A, Mac Grory B, Furie KL, Kim AS, Easton JD, Johnston SC, Henninger N. Carotid Stenosis and Recurrent Ischemic Stroke. Stroke 2021, 52: 2414-2417. PMID: 33940954, PMCID: PMC8268075, DOI: 10.1161/strokeaha.121.034089.Peer-Reviewed Original ResearchConceptsHigh-risk transient ischemic attackTransient ischemic attackEffect of clopidogrelMinor ischemic strokeIschemic strokeIschemic stroke riskCarotid stenosisIschemic attackStroke riskCervical internal carotid arteryAddition of clopidogrelDual antiplatelet therapyRecurrent ischemic strokeCox regression modelInternal carotid arteryAntiplatelet therapyPrimary outcomePoint trialCarotid arteryInclusion criteriaClopidogrelAdjusted modelStenosisPatientsStrokeAssociation of Preeclampsia With Incident Stroke in Later Life Among Women in the Framingham Heart Study
de Havenon A, Delic A, Stulberg E, Sheibani N, Stoddard G, Hanson H, Theilen L. Association of Preeclampsia With Incident Stroke in Later Life Among Women in the Framingham Heart Study. JAMA Network Open 2021, 4: e215077. PMID: 33900402, PMCID: PMC8076961, DOI: 10.1001/jamanetworkopen.2021.5077.Peer-Reviewed Original ResearchConceptsHistory of preeclampsiaVascular risk factorsIncident strokeRisk factorsFramingham Heart StudyMarginal structural modelsCohort studyStroke incidenceRelative riskHeart StudyLater lifeTime-varying covariatesMidlife vascular risk factorsPopulation-based cohort studyHigher diastolic blood pressureAbsence of preeclampsiaCholesterol-lowering medicationsDiastolic blood pressureAge 45 yearsAssociation of preeclampsiaBlood pressureMore pregnanciesStudy visitPreeclampsiaMAIN OUTCOME
2018
Increased blood pressure variability after endovascular thrombectomy for acute stroke is associated with worse clinical outcome
Bennett AE, Wilder MJ, McNally JS, Wold JJ, Stoddard GJ, Majersik JJ, Ansari S, de Havenon A. Increased blood pressure variability after endovascular thrombectomy for acute stroke is associated with worse clinical outcome. Journal Of NeuroInterventional Surgery 2018, 10: 823. PMID: 29352059, DOI: 10.1136/neurintsurg-2017-013473.Peer-Reviewed Original ResearchConceptsModified Rankin ScaleBlood pressure variabilityIntra-arterial therapyIntravenous tissue plasminogen activatorPressure variabilityTissue plasminogen activatorLogistic regression modelsOrdinal logistic regression modelsIschemic strokeWorse outcomesMean age 63.2 yearsMedian admission National InstitutesMultivariable ordinal logistic regression modelsSystolic blood pressure variabilityPlasminogen activatorAdmission National InstitutesWorse neurologic outcomeWorse clinical outcomesLogistic regression analysisOrdinal logistic regression analysisIndependent predictive abilitySuccessive variationAcute strokeEndovascular thrombectomyNeurologic outcome
2015
Tissue Plasminogen Activator Prescription and Administration Errors within a Regional Stroke System
Chung LS, Tkach A, Lingenfelter EM, Dehoney SB, Rollo J, de Havenon A, DeWitt LD, Grantz MR, Wang H, Wold JJ, Hannon PM, Weathered NR, Majersik JJ. Tissue Plasminogen Activator Prescription and Administration Errors within a Regional Stroke System. Journal Of Stroke And Cerebrovascular Diseases 2015, 25: 565-571. PMID: 26698642, PMCID: PMC4779727, DOI: 10.1016/j.jstrokecerebrovasdis.2015.11.014.Peer-Reviewed Original ResearchConceptsComprehensive stroke centerRegional stroke systemAcute ischemic strokeCommunity hospitalAdministration errorsStroke systemsWeight-based dosingMean age 68Ischemic strokeStroke centersStroke outcomeAIS patientsCH patientsAge 68Infusion rateSystemic hemorrhageAIS casesBody weightPharmacy informationPatientsIncorrect dosageOutcomesPrescriptionTPAAssociation