2024
APOE ε4 and Intracerebral Hemorrhage in Patients With Brain Arteriovenous Malformation
Renedo D, Rivier C, Koo A, Sujijantarat N, Clocchiatti-Tuozzo S, Wu K, Torres-Lopez V, Huo S, Gunel M, de Havenon A, Sheth K, Matouk C, Falcone G. APOE ε4 and Intracerebral Hemorrhage in Patients With Brain Arteriovenous Malformation. JAMA Network Open 2024, 7: e2355368. PMID: 38363572, PMCID: PMC10873768, DOI: 10.1001/jamanetworkopen.2023.55368.Peer-Reviewed Original ResearchConceptsApolipoprotein E e4Participants of European ancestryRisk of intracerebral hemorrhageHigh risk of intracerebral hemorrhageCross-sectional studyUK BiobankEuropean ancestryHigh riskUs Research ProgramUK Biobank participantsInternational Classification of DiseasesAssociated with higher risk of ICHCross-sectional study of patientsAPOE e4 statusClassification of DiseasesApolipoprotein ENinth Revision and Tenth RevisionAssociated with higher riskIndividual-level dataMultivariate logistic regressionIntracerebral hemorrhage riskBrain arteriovenous malformationsIntracerebral hemorrhageBiobank participantsTenth RevisionCOVID‐19 Infection Is Associated With Poor Outcomes in Patients With Intracerebral Hemorrhage
Renedo D, Leasure A, Young R, Rivier C, Alhanti B, Mac Grory B, Messe S, Reeves M, Hassan A, Schwamm L, de Havenon A, Matouk C, Sheth K, Falcone G. COVID‐19 Infection Is Associated With Poor Outcomes in Patients With Intracerebral Hemorrhage. Journal Of The American Heart Association 2024, 13: e030999. PMID: 38293940, PMCID: PMC11056169, DOI: 10.1161/jaha.123.030999.Peer-Reviewed Original ResearchConceptsOdds of poor outcomeIntracerebral hemorrhageCOVID-19 infectionPoor outcomeHealth care deliverySkilled nursing facilityMultivariate analysisOdds of mortalityConcomitant COVID-19 infectionAssociated with poor outcomesCare deliveryNursing facilitiesPoor functional outcomeCOVID-19OddsICH outcomeImpact of COVID-19No significant differenceObservational studyHemorrhagic strokeWorsen outcomesPatient populationFunctional outcomesStroke dataPatients
2023
Detection of Intracerebral Hemorrhage Using Low-Field, Portable Magnetic Resonance Imaging in Patients With Stroke
Mazurek M, Parasuram N, Peng T, Beekman R, Yadlapalli V, Sorby-Adams A, Lalwani D, Zabinska J, Gilmore E, Petersen N, Falcone G, Sujijantarat N, Matouk C, Payabvash S, Sze G, Schiff S, Iglesias J, Rosen M, de Havenon A, Kimberly W, Sheth K. Detection of Intracerebral Hemorrhage Using Low-Field, Portable Magnetic Resonance Imaging in Patients With Stroke. Stroke 2023, 54: 2832-2841. PMID: 37795593, PMCID: PMC11103256, DOI: 10.1161/strokeaha.123.043146.Peer-Reviewed Original ResearchClinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging – A pilot study
Abou Karam G, Tharmaseelan H, Aboian M, Malhotra A, Gilmore E, Falcone G, de Havenon A, Sheth K, Payabvash S. Clinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging – A pilot study. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107375. PMID: 37738914, PMCID: PMC10591892, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107375.Peer-Reviewed Original ResearchConceptsModified Rankin ScaleSecondary brain injuryIntracerebral hemorrhagePerihematomal edemaSubacute intracerebral hemorrhageIntravoxel incoherent motion imagingAdmission NIHSSBrain injuryMedian baseline National InstitutesPilot studyBaseline National InstitutesHealth Stroke ScalePerfusion fractionSupratentorial intracerebral hemorrhageIVIM metricsIncoherent motion imagingStroke ScaleNeuroprotective therapiesParenchymal injuryRankin ScaleRisk patientsConsecutive patientsUnivariable analysisPoor outcomeICH volume
2022
Mutation of breast cancer susceptibility genes increases cerebral microbleeds: A pilot study
Pope B, Wolcott Z, Castillo M, Jin J, Wong KH, Havenon A, Yaghi S, Goldstein ED. Mutation of breast cancer susceptibility genes increases cerebral microbleeds: A pilot study. Journal Of Stroke And Cerebrovascular Diseases 2022, 31: 106729. PMID: 36116220, DOI: 10.1016/j.jstrokecerebrovasdis.2022.106729.Peer-Reviewed Original ResearchConceptsCerebral small vessel diseaseCerebrovascular risk factorsBRCA mutationsCerebral microbleedsRisk factorsOdds ratioMarkers of CSVDBreast cancer susceptibility gene mutationsRetrospective cross-sectional analysisCancer susceptibility gene mutationsAdjusted odds ratioSmall vessel diseaseHosmer-Lemeshow testSusceptibility gene mutationsCross-sectional analysisLogistic regression modelsBreast cancer susceptibility genesVessel diseaseWildtype individualsBrain MRICancer susceptibility genesStudent's t-test analysisT-test analysisMalignancy evaluationClinical implications
2021
Endovascular Therapy of Anterior Circulation Tandem Occlusions
Anadani M, Marnat G, Consoli A, Papanagiotou P, Nogueira RG, Siddiqui A, Ribo M, Spiotta AM, Bourcier R, Kyheng M, Labreuche J, de Havenon A, Sibon I, Dargazanli C, Arquizan C, Cognard C, Olivot JM, Anxionnat R, Audibert G, Mazighi M, Blanc R, Lapergue B, Richard S, Gory B, Turjman F, Piotin M, Steglich-Arnholm H, Holtmannspötter M, Taschner C, Eiden S, Haussen D, Boutchakova M, Dorn F, Killer-Oberpfalzer M, Mangiafico S, Psychogios M, Labeyrie M, Biondi A, Bracard S, Grossberg J, Guenego A, Darcourt J, Vukasinovic I, Pomero E, Davies J, Renieri L, Hecker C, Muchada M, Rodesch G, Houdart E, Lockau J, Kastrup A, Redjem H, Behme D, Shallwani H, Christopher M, Mione G, Humbertjean L, Riou-Comte N, Zhu F, Derelle A, Liao L, Piotin M, Redjem H, Escalard S, Maïer B, Desilles J, Ciccio G, Smajda S, Obadia M, Sabben C, Corabianu O, de Broucker T, Smadja D, Alamowitch S, Ille O, Manchon E, Garcia P, Taylor G, Maacha M, Wang A, Evrard S, Tchikviladze M, Ajili N, Weisenburger D, Gorza L, Coskun O, Di Maria F, Rodesh G, Leguen M, Gratieux J, Pico F, Rakotoharinandrasana H, Tassan P, Poll R, Marinier S, Gariel F, Barreau X, Berge J, Veunac L, Menegon P, Lucas L, Olindo S, Renou P, Sagnier S, Poli M, Debruxelles S, Tourdias T, Liegey J, Detraz L, Daumas-Duport B, Alexandre P, Roy M, Lenoble C, L’allinec V, Girot J, Desal H, Bechiri F, Bracard S, Braun M, Derelle A, Tonnelet R, Liao L, Zhu F, Schmitt E, Planel S, Humbertjean L, Mione G, Lacour J, Hossu G, Beaumont M, Bailang M, Reitter M, Masson A, Alb L, Tabarna A, Voicu M, Podar I, Brezeanu M, Guy S, Costalat V, Gascou G, Lefèvre P, Derraz I, Riquelme C, Gaillard N, Mourand I, Corti L. Endovascular Therapy of Anterior Circulation Tandem Occlusions. Stroke 2021, 52: 3097-3105. PMID: 34372671, DOI: 10.1161/strokeaha.120.033032.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnterior Cerebral ArteryArterial Occlusive DiseasesCarotid Artery, InternalCarotid Artery, Internal, DissectionCerebral HemorrhageEndovascular ProceduresFemaleFranceHumansIntracranial ArteriosclerosisIschemic StrokeMaleMiddle AgedPatient SafetyPropensity ScoreRegistriesStentsStrokeThrombectomyTreatment OutcomeConceptsAnterior circulation tandem occlusionTandem occlusion strokeAcute ischemic strokeStent groupEndovascular therapyIntracerebral hemorrhageTandem occlusionsHigher oddsFavorable outcomeIschemic strokeOcclusion strokeTreatment approachesParenchymal hemorrhage type 2Internal carotid artery lesionsPropensity score-adjusted analysisAcute carotid stentingSymptomatic intracerebral hemorrhageCarotid artery lesionsIndividual patient dataBest treatment approachCurrent clinical practiceDifferent treatment approachesHigh rateSuccessful reperfusionAnterior circulationImpact of COVID-19 on the hospitalization, treatment, and outcomes of intracerebral and subarachnoid hemorrhage in the United States
Ravindra VM, Grandhi R, Delic A, Hohmann S, Shippey E, Tirschwell D, Frontera JA, Yaghi S, Majersik JJ, Anadani M, de Havenon A. Impact of COVID-19 on the hospitalization, treatment, and outcomes of intracerebral and subarachnoid hemorrhage in the United States. PLOS ONE 2021, 16: e0248728. PMID: 33852591, PMCID: PMC8046225, DOI: 10.1371/journal.pone.0248728.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCerebral HemorrhageChildChild, PreschoolCohort StudiesCOVID-19EthnicityFemaleHospital MortalityHospitalizationHumansInfantLength of StayMaleMiddle AgedMinority GroupsPatient DischargeRetrospective StudiesSARS-CoV-2Subarachnoid HemorrhageTreatment OutcomeUnited StatesConceptsAdjusted odds ratioHospital death rateIntensive care stayOutcome of deathIntracerebral hemorrhageSubarachnoid hemorrhageFavorable dischargeCOVID-19Vizient Clinical Data BaseDeath rateLonger hospital lengthIntensive care lengthLength of hospitalLonger hospital stayCohort of patientsMixed-effects logistic regression modelSpontaneous intracerebral hemorrhageCOVID-19 infectionClinical data baseLogistic regression modelsICH controlsHospital deathHospital stayHospital lengthSecondary outcomesVessel Wall Enhancement on Black-Blood MRI Predicts Acute and Future Stroke in Cerebral Amyloid Angiopathy
McNally JS, Sakata A, Alexander MD, Dewitt LD, Sonnen JA, Menacho ST, Stoddard GJ, Kim S, de Havenon AH. Vessel Wall Enhancement on Black-Blood MRI Predicts Acute and Future Stroke in Cerebral Amyloid Angiopathy. American Journal Of Neuroradiology 2021, 42: 1038-1045. PMID: 33737266, PMCID: PMC8191668, DOI: 10.3174/ajnr.a7047.Peer-Reviewed Original ResearchMeSH KeywordsAgedBrain IschemiaCerebral Amyloid AngiopathyCerebral HemorrhageFemaleHumansMagnetic Resonance ImagingMaleRetrospective StudiesStrokeConceptsCerebral amyloid angiopathyFuture ischemic strokeVessel wall enhancementIschemic strokeAmyloid angiopathyWall enhancementFuture strokeC-statisticVessel wall MRNew-onset neurologic symptomsInitial ischemic strokeStroke-free survivalAcute ischemic strokeIschemic stroke incidenceCAA patientsFinal regression modelNeurologic symptomsStroke incidenceCerebral amyloidCox regressionRetrospective studyRisk factorsMultivariable PoissonNegative participantsAngiopathy
2019
End-of-Treatment Intracerebral and Ventricular Hemorrhage Volume Predicts Outcome
de Havenon A, Joyce E, Yaghi S, Ansari S, Delic A, Taussky P, Alexander M, Tirschwell D, Grandhi R. End-of-Treatment Intracerebral and Ventricular Hemorrhage Volume Predicts Outcome. Stroke 2019, 51: 652-654. PMID: 31842688, PMCID: PMC7000178, DOI: 10.1161/strokeaha.119.028199.Peer-Reviewed Original ResearchConceptsIntraventricular hemorrhage volumeIntracerebral hemorrhageClot evacuationHemorrhage volumeBetter outcomesVolume scoreInvasive clot evacuationMISTIE III trialSurgical clot evacuationGood neurological outcomePotential clinical benefitNeurological outcomeIII trialsPrimary outcomeClinical benefitHematoma volumePoor outcomeFunctional outcomeSurgical armICH sizeTherapeutic planningSecondary analysisPatientsStrong associationStratification scale
2018
Increased Blood Pressure Variability Contributes to Worse Outcome After Intracerebral Hemorrhage
de Havenon A, Majersik JJ, Stoddard G, Wong KH, McNally JS, Smith AG, Rost NS, Tirschwell DL. Increased Blood Pressure Variability Contributes to Worse Outcome After Intracerebral Hemorrhage. Stroke 2018, 49: 1981-1984. PMID: 30012822, PMCID: PMC6202185, DOI: 10.1161/strokeaha.118.022133.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntihypertensive AgentsBlood PressureCerebral HemorrhageFemaleHumansHypertensionMaleMiddle AgedTreatment OutcomeConceptsBlood pressure variabilitySystolic blood pressure variabilitySystolic blood pressureNeurological outcomeRankin ScaleBlood pressureAcute periodIntracerebral hemorrhageWorse outcomesPressure variabilityLong-term neurological outcomeUtility-weighted modified Rankin scaleWorse neurological outcomeAcute ischemic strokeModified Rankin ScaleBlood pressure meansATACH-2 trialProtocol-based approachATACH-2Ischemic strokeSecondary outcomesPrimary outcomeEarly identificationSecondary analysisConsistent association