White matter hyperintensity on MRI and plasma Aβ42/40 ratio additively increase the risk of cognitive impairment in hypertensive adults
de Havenon A, Gottesman R, Willamson J, Rost N, Sharma R, Li V, Littig L, Stulberg E, Falcone G, Prabhakaran S, Schneider A, Sheth K, Pajewski N, Brickman A. White matter hyperintensity on MRI and plasma Aβ42/40 ratio additively increase the risk of cognitive impairment in hypertensive adults. Alzheimer's & Dementia 2024, 20: 6810-6819. PMID: 39229896, PMCID: PMC11485393, DOI: 10.1002/alz.14126.Peer-Reviewed Original ResearchRisk of cognitive impairmentYears of follow-upCognitive impairmentExposure categoriesHigh-risk categoryWhite matter hyperintensitySystolic Blood Pressure Intervention TrialRates of cognitive impairmentSPRINT-MIND trialDementia preventionFollow-upLow-risk categoryMIND trialAdditional risk factorsDevelopment of cognitive impairmentIntervention trialsHypertensive adultsHazard ratioRisk factorsHigh riskLow riskVascular healthTertileRiskImpairmentBurden of Neurologic Health Care and Incident Neurologic Diagnoses in the Year After COVID-19 or Influenza Hospitalization.
de Havenon A, Callaghan B, Xu Y, Connor M, Hill C, Ney J, Esper G. Burden of Neurologic Health Care and Incident Neurologic Diagnoses in the Year After COVID-19 or Influenza Hospitalization. Neurology 2024, 102: e209248. PMID: 38507675, PMCID: PMC11383855, DOI: 10.1212/wnl.0000000000209248.Peer-Reviewed Original ResearchConceptsHealth care encountersNeurological diagnosisCare encountersHealth careCollection of electronic health recordsHospital-based careHealth Research NetworkElectronic health recordsEmergency department visitsCohort of adultsYears of follow-upGlobal health research networkPatient-level dataElixhauser comorbidity scorePropensity score matchingHealth recordsMovement disordersDepartment visitsEMR dataPatient's residenceMarital statusAnalysis of patient-level dataNearest neighbor propensity score matchingIncident eventsHazard ratio