2021
The association between transthoracic echocardiogram parameters and white matter hyperintensities
Navarro KS, Wong KH, Ibrahim MM, de Havenon AH, Goldstein ED. The association between transthoracic echocardiogram parameters and white matter hyperintensities. Clinical Neurology And Neurosurgery 2021, 206: 106672. PMID: 33979694, DOI: 10.1016/j.clineuro.2021.106672.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingBrain magnetic resonance imagingCerebral small vessel diseaseVentricular ejection fractionCardiac chamber sizeTransthoracic echocardiogramFazekas scoreEjection fractionAtrial areaTricuspid annular plane systolic excursionAnnular plane systolic excursionRight ventricular ejection fractionRight ventricular internal diameterRetrospective chart reviewRight atrial areaSmall vessel diseaseVentricular internal diameterMultivariate ordinal logistic regression modelWhite matter hyperintensitiesChamber sizeLogistic regression modelsOrdinal logistic regression modelsMore WMHChart reviewSystolic excursion
2018
Increased blood pressure variability after endovascular thrombectomy for acute stroke is associated with worse clinical outcome
Bennett AE, Wilder MJ, McNally JS, Wold JJ, Stoddard GJ, Majersik JJ, Ansari S, de Havenon A. Increased blood pressure variability after endovascular thrombectomy for acute stroke is associated with worse clinical outcome. Journal Of NeuroInterventional Surgery 2018, 10: 823. PMID: 29352059, DOI: 10.1136/neurintsurg-2017-013473.Peer-Reviewed Original ResearchConceptsModified Rankin ScaleBlood pressure variabilityIntra-arterial therapyIntravenous tissue plasminogen activatorPressure variabilityTissue plasminogen activatorLogistic regression modelsOrdinal logistic regression modelsIschemic strokeWorse outcomesMean age 63.2 yearsMedian admission National InstitutesMultivariable ordinal logistic regression modelsSystolic blood pressure variabilityPlasminogen activatorAdmission National InstitutesWorse neurologic outcomeWorse clinical outcomesLogistic regression analysisOrdinal logistic regression analysisIndependent predictive abilitySuccessive variationAcute strokeEndovascular thrombectomyNeurologic outcome
2017
Association of Collateral Blood Vessels Detected by Arterial Spin Labeling Magnetic Resonance Imaging With Neurological Outcome After Ischemic Stroke
de Havenon A, Haynor DR, Tirschwell DL, Majersik JJ, Smith G, Cohen W, Andre JB. Association of Collateral Blood Vessels Detected by Arterial Spin Labeling Magnetic Resonance Imaging With Neurological Outcome After Ischemic Stroke. JAMA Neurology 2017, 74: 453-458. PMID: 28192548, PMCID: PMC5470363, DOI: 10.1001/jamaneurol.2016.4491.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeArterial spin labeling magnetic resonance imagingCollateral blood vesselsNeurologic outcomeMRS scoreMagnetic resonance imagingNeurological outcomeIschemic strokeScale scoreHealth Stroke Scale scoreResonance imagingMultivariable ordinal logistic regression modelsTertiary academic medical centerBlood vesselsAdmission National InstitutesPremorbid mRS scoreGood neurologic outcomeGood neurological outcomeRetrospective cohort studyStroke Scale scoreRankin Scale scorePresence of collateralsAcademic medical centerLogistic regression modelsOrdinal logistic regression modelsDeterminants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke
de Havenon A, Bennett A, Stoddard GJ, Smith G, Chung L, O'Donnell S, McNally JS, Tirschwell D, Majersik JJ. Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke. Stroke And Vascular Neurology 2017, 2: 1. PMID: 28959484, PMCID: PMC5435214, DOI: 10.1136/svn-2016-000057.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood PressureBlood Pressure DeterminationCerebral AngiographyCerebrovascular CirculationCollateral CirculationComputed Tomography AngiographyDisability EvaluationFemaleHumansIschemic StrokeMaleMiddle AgedNeuroimagingPatient AdmissionPerfusion ImagingPredictive Value of TestsPrognosisRecovery of FunctionRetrospective StudiesRisk FactorsTime FactorsConceptsBlood pressure variabilityProximal vessel occlusionAcute ischemic strokeIschemic strokeVessel occlusionNeurological outcomeBPV indicesPressure variabilityAcute anterior circulation ischemic strokeAnterior circulation ischemic strokeIntravenous tissue plasminogen activatorGood collateral vesselsIschemic core volumeLarger mismatch volumeWorse neurological outcomeAcute stroke therapySubset of patientsSystolic blood pressureTissue plasminogen activatorLogistic regression modelsOrdinal logistic regression modelsEndovascular thrombectomyIschemic penumbraStroke onsetStroke outcome
2016
Increased Blood Pressure Variability Is Associated with Worse Neurologic Outcome in Acute Anterior Circulation Ischemic Stroke
de Havenon A, Bennett A, Stoddard GJ, Smith G, Wang H, Wold J, Chung L, Tirschwell DL, Majersik JJ. Increased Blood Pressure Variability Is Associated with Worse Neurologic Outcome in Acute Anterior Circulation Ischemic Stroke. Stroke Research And Treatment 2016, 2016: 7670161. PMID: 27974991, PMCID: PMC5126417, DOI: 10.1155/2016/7670161.Peer-Reviewed Original ResearchBlood pressure variabilityLower mean blood pressureSystolic blood pressure variabilityMean blood pressureWorse neurologic outcomeBlood pressureIschemic strokeNeurologic outcomeVessel occlusionPressure variabilityAcute anterior circulation ischemic strokeAnterior circulation ischemic strokeAcute ischemic stroke patientsDiastolic blood pressure variabilityProximal vessel occlusionAcute ischemic strokeAnterior circulation strokeIschemic stroke patientsLogistic regression modelsOrdinal logistic regression modelsRankin ScaleAcute settingThrombolytic therapyStroke patientsPatient population