2021
Toxic Metabolic Encephalopathy in Hospitalized Patients with COVID-19
Frontera JA, Melmed K, Fang T, Granger A, Lin J, Yaghi S, Zhou T, Lewis A, Kurz S, Kahn DE, de Havenon A, Huang J, Czeisler BM, Lord A, Meropol SB, Troxel AB, Wisniewski T, Balcer L, Galetta S. Toxic Metabolic Encephalopathy in Hospitalized Patients with COVID-19. Neurocritical Care 2021, 35: 693-706. PMID: 33725290, PMCID: PMC7962078, DOI: 10.1007/s12028-021-01220-5.Peer-Reviewed Original ResearchConceptsHypoxic-ischemic encephalopathyHospital mortalityTime-dependent Cox proportional hazards modelsSequential Organ Failure Assessment scoreSevere acute respiratory syndrome coronavirus 2Organ Failure Assessment scoreAcute respiratory syndrome coronavirus 2Intensive care unit requirementSARS-CoV-2 infectionCOVID-19Cox proportional hazards modelRespiratory syndrome coronavirus 2Longer hospital lengthNew York City hospitalsPrimary neurological diagnosisStructural brain diseaseToxic-metabolic encephalopathyDate of admissionSyndrome coronavirus 2Proportional hazards modelCoronavirus disease 2019Coprimary outcomesHospital deathHospital lengthObservational cohort
2018
Low b-value diffusion weighted imaging is promising in the diagnosis of brain death and hypoxic-ischemic injury secondary to cardiopulmonary arrest
Peckham ME, Anderson JS, Rassner UA, Shah LM, Hinckley PJ, de Havenon A, Kim SE, McNally JS. Low b-value diffusion weighted imaging is promising in the diagnosis of brain death and hypoxic-ischemic injury secondary to cardiopulmonary arrest. Critical Care 2018, 22: 165. PMID: 29925413, PMCID: PMC6011248, DOI: 10.1186/s13054-018-2087-9.Peer-Reviewed Original ResearchConceptsHypoxic-ischemic encephalopathyBrain deathGlobal hypoperfusionNormal subjectsDiagnosis of HIEHypoxic-ischemic brain injuryMatter regionsHypoxic-ischemic injuryIschemic brain injurySex-matched controlsLow b-value DWIApparent diffusion coefficient (ADC) valuesGray matter regionsWhite matter regionsWhite matter valuesIschemic encephalopathyDelayed DiagnosisArrest patientsCardiopulmonary arrestCardiorespiratory arrestBrain injuryInclusion criteriaBD subjectsOrgan donorsGray matter
2015
Medial Occipital Lobe Hyperperfusion Identified by Arterial Spin-Labeling: A Poor Prognostic Sign in Patients with Hypoxic-Ischemic Encephalopathy
de Havenon A, Sultan-Qurraie A, Tirschwell D, Cohen W, Majersik J, Andre JB. Medial Occipital Lobe Hyperperfusion Identified by Arterial Spin-Labeling: A Poor Prognostic Sign in Patients with Hypoxic-Ischemic Encephalopathy. American Journal Of Neuroradiology 2015, 36: 2292-2295. PMID: 26338917, PMCID: PMC7964282, DOI: 10.3174/ajnr.a4444.Peer-Reviewed Original ResearchConceptsHypoxic-ischemic encephalopathyModerate hypoxic-ischemic encephalopathyCohort of patientsPoor prognostic signArterial spin-labeling MRArterial spin labelingHospital dischargeAdult patientsPrognostic signPrognostic valueProspective InvestigationUncertain prognosisHyperperfusionPatientsEncephalopathyArterial spin labeling dataCBF mapsHigher likelihoodROI placementVoxel basisSpin labelingQuantitative CBF mapsRegional increaseDistinctive patternsPrognosis