Welcome to the Schlieker Lab
The nuclear envelope is a complex and highly dynamic structure that is also a hot spot for human diseases collectively known as nuclear envelopathies. Research in our laboratory focuses on furthering our understanding of nuclear protein quality control, transport of large cargo across the nuclear membranes, and the relationship between nuclear membrane proteins and human disease.
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Excited to have our newest paper online! Here, we use APEX technology to reveal the proteome of ER-LD contacts. Check for your protein!
We also define interactions with ER-LD tether Snx14 & desaturase SCD1, giving insights for neurological disease SCAR20.
https://t.co/DWYDAEG6yG https://t.co/CSeBrmSTrZ3 DAYS AGO
How does the Rheb GTPase find and activate mTORC1 at lysosomes? In this new review, Brittany Angarola and I do our best to answer this question. Thanks to the reviewers who helped to focus our message! @RobertoZoncu @LoewithLab @DMSabatini Rolf Heumann
https://t.co/cBpVlt3YpZ8 DAYS AGO
Happy to share our new @biorxivpreprint describing the structure & M.o.A. of PDIP38 - the first CLPX adaptor protein from mammalian mitochondria. 🙏 to the team 4 all their efforts over the years, esp. the long term collabs with Truscott @LIMSLTU & Zeth @MPI_for_DB @roskildeuni9 DAYS AGO
