Publications

• Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins.Tsai PL, Cameron CJF, Forni MF, Wasko RR, Naughton BS, Horsley V, Gerstein MB, Schlieker C. Cell Rep. 2022 Nov 22. PMID: 36417855.
• Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities.Prophet SM, Rampello AJ, Niescier RF, Gentile JE, Mallik S, Koleske AJ, Schlieker C. Nat Cell Biol. 2022 Nov; 2022 Oct 27. PMID: 36302970.
• Neural network based successor representations to form cognitive maps of space and language.Stoewer P, Schlieker C, Schilling A, Metzner C, Maier A, Krauss P. Sci Rep. 2022 Jul 4; 2022 Jul 4. PMID: 35787659.
• p97/UBXD1 Generate Ubiquitylated Proteins That Are Sequestered into Nuclear Envelope Herniations in Torsin-Deficient Cells.Prophet SM, Naughton BS, Schlieker C. Int J Mol Sci. 2022 Apr 21; 2022 Apr 21. PMID: 35563018.
• Nodal modulator (NOMO) is required to sustain endoplasmic reticulum morphology.Amaya C, Cameron CJF, Devarkar SC, Seager SJH, Gerstein MB, Xiong Y, Schlieker C. J Biol Chem. 2021 Aug; 2021 Jul 3. PMID: 34224731.
• Lipid and protein dynamics that shape nuclear envelope identity.Bahmanyar S, Schlieker C. Mol Biol Cell. 2020 Jun 15. PMID: 32530796.
• Torsin ATPase deficiency leads to defects in nuclear pore biogenesis and sequestration of MLF2.Rampello AJ, Laudermilch E, Vishnoi N, Prophet SM, Shao L, Zhao C, Lusk CP, Schlieker C. J Cell Biol. 2020 Jun 1. PMID: 32342107.
• The Role of Torsin AAA+ Proteins in Preserving Nuclear Envelope Integrity and Safeguarding Against Disease.Rampello AJ, Prophet SM, Schlieker C. Biomolecules. 2020 Mar 19; 2020 Mar 19. PMID: 32204310.
• An unbiased approach de-livers unexpected insight into torsin biology.Prophet SM, Schlieker C. J Clin Invest. 2019 Nov 1. PMID: 31589164.
• Methodologies to monitor protein turnover at the inner nuclear membrane.Tsai PL, Zhao C, Schlieker C. Methods Enzymol. 2019; 2019 Feb 8. PMID: 30910029.
• Dynamic functional assembly of the Torsin AAA+ ATPase and its modulation by LAP1.Chase AR, Laudermilch E, Wang J, Shigematsu H, Yokoyama T, Schlieker C. Mol Biol Cell. 2017 Oct 15; 2017 Aug 16. PMID: 28814508.
• Torsin ATPases: Harnessing Dynamic Instability for Function.Chase AR, Laudermilch E, Schlieker C. Front Mol Biosci. 2017; 2017 May 11. PMID: 28553638.
• Dissecting Torsin/cofactor function at the nuclear envelope: a genetic study.Laudermilch E, Tsai PL, Graham M, Turner E, Zhao C, Schlieker C. Mol Biol Cell. 2016 Dec 15; 2016 Oct 26. PMID: 27798237.
• Pelger-Huët anomaly and Greenberg skeletal dysplasia: LBR-associated diseases of cholesterol metabolism.Turner EM, Schlieker C. Rare Dis. 2016; 2016 Sep 27. PMID: 27830109.
• The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations.Tsai PL, Zhao C, Turner E, Schlieker C. Elife. 2016 Jun 23; 2016 Jun 23. PMID: 27336722.
• Torsin ATPases: structural insights and functional perspectives.Laudermilch E, Schlieker C. Curr Opin Cell Biol. 2016 Jun; 2016 Jan 21. PMID: 26803745.
• Site-specific Proteolysis Mobilizes TorsinA from the Membrane of the Endoplasmic Reticulum (ER) in Response to ER Stress and B Cell Stimulation.Zhao C, Brown RS, Tang CH, Hu CC, Schlieker C. J Biol Chem. 2016 Apr 29; 2016 Mar 7. PMID: 26953341.
• A designed repeat protein as an affinity capture reagent.Speltz EB, Brown RS, Hajare HS, Schlieker C, Regan L. Biochem Soc Trans. 2015 Oct. PMID: 26517897.
• The Torsin Activator LULL1 Is Required for Efficient Growth of Herpes Simplex Virus 1.Turner EM, Brown RS, Laudermilch E, Tsai PL, Schlieker C. J Virol. 2015 Aug; 2015 Jun 3. PMID: 26041288.
• Torsins: not your typical AAA+ ATPases.Rose AE, Brown RS, Schlieker C. Crit Rev Biochem Mol Biol. 2015; 2015 Oct 13. PMID: 26592310.
• The mechanism of Torsin ATPase activation.Brown RS, Zhao C, Chase AR, Wang J, Schlieker C. Proc Natl Acad Sci U S A. 2014 Nov 11; 2014 Oct 28. PMID: 25352667.
• Arresting a Torsin ATPase reshapes the endoplasmic reticulum.Rose AE, Zhao C, Turner EM, Steyer AM, Schlieker C. J Biol Chem. 2014 Jan 3; 2013 Nov 25. PMID: 24275647.
• Regulation of Torsin ATPases by LAP1 and LULL1.Zhao C, Brown RS, Chase AR, Eisele MR, Schlieker C. Proc Natl Acad Sci U S A. 2013 Apr 23; 2013 Apr 8. PMID: 23569223.
• A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation.Sehrawat S, Koenig PA, Kirak O, Schlieker C, Fankhauser M, Ploegh HL. Blood. 2013 Feb 14; 2012 Dec 13. PMID: 23243279.
• Alternative nuclear transport for cellular protein quality control.Rose A, Schlieker C. Trends Cell Biol. 2012 Oct; 2012 Jul 31. PMID: 22858153.
• Enzymatic blockade of the ubiquitin-proteasome pathway.Ernst R, Claessen JH, Mueller B, Sanyal S, Spooner E, van der Veen AG, Kirak O, Schlieker CD, Weihofen WA, Ploegh HL. PLoS Biol. 2011 Mar; 2011 Mar 29. PMID: 21468303.
• Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier.Van der Veen AG, Schorpp K, Schlieker C, Buti L, Damon JR, Spooner E, Ploegh HL, Jentsch S. Proc Natl Acad Sci U S A. 2011 Feb 1; 2011 Jan 5. PMID: 21209336.
• DNA repair: Blocking ubiquitin transfer.Rose A, Schlieker C. Nature. 2010 Aug 19. PMID: 20725029.
• The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.Ernst R, Mueller B, Ploegh HL, Schlieker C. Mol Cell. 2009 Oct 9. PMID: 19818707.
• A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway.Schlieker CD, Van der Veen AG, Damon JR, Spooner E, Ploegh HL. Proc Natl Acad Sci U S A. 2008 Nov 25; 2008 Nov 18. PMID: 19017811.
• Mechanisms, biology and inhibitors of deubiquitinating enzymes.Love KR, Catic A, Schlieker C, Ploegh HL. Nat Chem Biol. 2007 Nov. PMID: 17948018.
• A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection.Gredmark S, Schlieker C, Quesada V, Spooner E, Ploegh HL. J Virol. 2007 Oct; 2007 Jul 18. PMID: 17634221.
• Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes.Schlieker C, Weihofen WA, Frijns E, Kattenhorn LM, Gaudet R, Ploegh HL. Mol Cell. 2007 Mar 9. PMID: 17349955.
• A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae.Schlieker C, Korbel GA, Kattenhorn LM, Ploegh HL. J Virol. 2005 Dec. PMID: 16306630.
• ClpV, a unique Hsp100/Clp member of pathogenic proteobacteria.Schlieker C, Zentgraf H, Dersch P, Mogk A. Biol Chem. 2005 Nov. PMID: 16307477.
• Novel insights into the mechanism of chaperone-assisted protein disaggregation.Weibezahn J, Schlieker C, Tessarz P, Mogk A, Bukau B. Biol Chem. 2005 Aug. PMID: 16201868.
• Solubilization of aggregated proteins by ClpB/DnaK relies on the continuous extraction of unfolded polypeptides.Schlieker C, Tews I, Bukau B, Mogk A. FEBS Lett. 2004 Dec 17. PMID: 15589844.
• Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB.Weibezahn J, Tessarz P, Schlieker C, Zahn R, Maglica Z, Lee S, Zentgraf H, Weber-Ban EU, Dougan DA, Tsai FT, Mogk A, Bukau B. Cell. 2004 Nov 24. PMID: 15550247.
• Substrate recognition by the AAA+ chaperone ClpB.Schlieker C, Weibezahn J, Patzelt H, Tessarz P, Strub C, Zeth K, Erbse A, Schneider-Mergener J, Chin JW, Schultz PG, Bukau B, Mogk A. Nat Struct Mol Biol. 2004 Jul; 2004 Jun 20. PMID: 15208691.
• A PDZ switch for a cellular stress response.Schlieker C, Mogk A, Bukau B. Cell. 2004 May 14. PMID: 15137934.
• Broad yet high substrate specificity: the challenge of AAA+ proteins.Mogk A, Dougan D, Weibezahn J, Schlieker C, Turgay K, Bukau B. J Struct Biol. 2004 Apr-May. PMID: 15037240.
• Poly-L-lysine enhances the protein disaggregation activity of ClpB.Strub C, Schlieker C, Bukau B, Mogk A. FEBS Lett. 2003 Oct 9. PMID: 14550559.
• Characterization of a trap mutant of the AAA+ chaperone ClpB.Weibezahn J, Schlieker C, Bukau B, Mogk A. J Biol Chem. 2003 Aug 29; 2003 Jun 12. PMID: 12805357.
• Refolding of substrates bound to small Hsps relies on a disaggregation reaction mediated most efficiently by ClpB/DnaK.Mogk A, Schlieker C, Friedrich KL, Schönfeld HJ, Vierling E, Bukau B. J Biol Chem. 2003 Aug 15; 2003 Jun 4. PMID: 12788951.
• Roles of individual domains and conserved motifs of the AAA+ chaperone ClpB in oligomerization, ATP hydrolysis, and chaperone activity.Mogk A, Schlieker C, Strub C, Rist W, Weibezahn J, Bukau B. J Biol Chem. 2003 May 16; 2003 Mar 6. PMID: 12624113.
• Prevention and reversion of protein aggregation by molecular chaperones in the E. coli cytosol: implications for their applicability in biotechnology.Schlieker C, Bukau B, Mogk A. J Biotechnol. 2002 Jun 13. PMID: 12142139.