Welcome to the Schlieker Lab

We explore how cells build and safeguard two vital structures — the nuclear envelope and the endoplasmic reticulum— to ensure protein quality control and cellular homeostasis. Our work focuses on how disruptions in membrane organization and phase separation drive the formation of aberrant condensates connected to neurological disease.

To tackle these questions, we develop and apply new tools that let us probe and modulate these processes across scales. By integrating cell biology, biochemistry, and computational approaches, we aim to uncover fundamental principles of cellular organization and translate these discoveries into novel therapeutic strategies.