2023
Impact of postnatal weight gain on brain white matter maturation in very preterm infants
Bobba P, Weber C, Higaki A, Mukherjee P, Scheinost D, Constable R, Ment L, Taylor S, Payabvash S. Impact of postnatal weight gain on brain white matter maturation in very preterm infants. Journal Of Neuroimaging 2023, 33: 991-1002. PMID: 37483073, PMCID: PMC10800683, DOI: 10.1111/jon.13145.Peer-Reviewed Original ResearchMeSH KeywordsBirth WeightBrainDiffusion Tensor ImagingFemaleHumansInfantInfant, NewbornInfant, PrematurePregnancyWhite MatterConceptsBirth weight z-scoreMagnetic resonance imagingVery preterm infantsPostnatal weight gainWeight z-scoreWhite matter maturationBirth weightDiffusion tensor imagingNeurological outcomePreterm infantsGestational ageWeight gainCorpus callosumHigher birth weight z-scoresBrain white matter maturationLong-term neurological deficitsZ-scoreBrain developmentWeight z-score changeWM tractsZ-score changeWM maturationWeeks of lifeNeurological deficitsNutritional intervention
2020
Functional brain connectivity in ex utero premature infants compared to in utero fetuses
De Asis-Cruz J, Kapse K, Basu SK, Said M, Scheinost D, Murnick J, Chang T, du Plessis A, Limperopoulos C. Functional brain connectivity in ex utero premature infants compared to in utero fetuses. NeuroImage 2020, 219: 117043. PMID: 32534962, PMCID: PMC7493786, DOI: 10.1016/j.neuroimage.2020.117043.Peer-Reviewed Original ResearchConceptsPremature infantsHealthy fetusesBrain connectivityStructural brain injuryBlood oxygenation level-dependent (BOLD) signalBrain structural changesStress-related areasNormal brain MRIState functional MRIFunctional connectivity strengthFunctional brain connectivityLevel-dependent signalMedial temporal lobeNetwork-based statisticsSeed-based correlation analysisUtero fetusesBasal gangliaBrain injuryTerm ageBrain MRITemporal lobeExposure altersInfantsRegion of interestFunctional MRI
2016
Functional magnetic resonance connectivity studies in infants born preterm: suggestions of proximate and long‐lasting changes in language organization
Kwon SH, Scheinost D, Vohr B, Lacadie C, Schneider K, Dai F, Sze G, Constable RT, Ment LR. Functional magnetic resonance connectivity studies in infants born preterm: suggestions of proximate and long‐lasting changes in language organization. Developmental Medicine & Child Neurology 2016, 58: 28-34. PMID: 27027605, PMCID: PMC6426123, DOI: 10.1111/dmcn.13043.Peer-Reviewed Original ResearchPrenatal stress alters amygdala functional connectivity in preterm neonates
Scheinost D, Kwon SH, Lacadie C, Sze G, Sinha R, Constable RT, Ment LR. Prenatal stress alters amygdala functional connectivity in preterm neonates. NeuroImage Clinical 2016, 12: 381-388. PMID: 27622134, PMCID: PMC5009231, DOI: 10.1016/j.nicl.2016.08.010.Peer-Reviewed Original ResearchConceptsPrenatal stress exposurePreterm neonatesPreterm birthPrenatal stressStress exposureTerm controlsFunctional connectivityAmygdala connectivityNeuropsychiatric disordersResting-state functional magnetic resonance imagingPrenatal stress altersEarly life stressFunctional magnetic resonance imagingMagnetic resonance imagingPeristriate cortexPrenatal exposureHigh riskMaternal stressIndependent cohortNeonatesLeft amygdalaSubcortical regionsResonance imagingAmygdalaCohort
2015
Alterations in Anatomical Covariance in the Prematurely Born
Scheinost D, Kwon SH, Lacadie C, Vohr BR, Schneider KC, Papademetris X, Constable RT, Ment LR. Alterations in Anatomical Covariance in the Prematurely Born. Cerebral Cortex 2015, 27: 534-543. PMID: 26494796, PMCID: PMC5939217, DOI: 10.1093/cercor/bhv248.Peer-Reviewed Original ResearchPreterm birth alters neonatal, functional rich club organization
Scheinost D, Kwon SH, Shen X, Lacadie C, Schneider KC, Dai F, Ment LR, Constable RT. Preterm birth alters neonatal, functional rich club organization. Brain Structure And Function 2015, 221: 3211-3222. PMID: 26341628, PMCID: PMC4779074, DOI: 10.1007/s00429-015-1096-6.Peer-Reviewed Original ResearchConceptsPT neonatesTerm neonatesRich-club organizationPreterm birth altersTerm-equivalent ageClub organizationFunctional magnetic resonance imagingMagnetic resonance imagingPT birthBirth altersWhole-brain networksNeonatesResonance imagingPretermFunctional connectivityFunctional segregationCognitive difficultiesEquivalent ageFunctional organizationBrain
2014
GABA, Resting-State Connectivity and the Developing Brain
Kwon SH, Scheinost D, Lacadie C, Benjamin J, Myers EH, Qiu M, Schneider KC, Rothman DL, Constable RT, Ment LR. GABA, Resting-State Connectivity and the Developing Brain. Neonatology 2014, 106: 149-155. PMID: 24970028, PMCID: PMC4134402, DOI: 10.1159/000362433.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidTerm-equivalent agePreterm infantsGABA concentrationTerm controlsFunctional connectivityMagnetic resonance imaging (MRI) scansFunctional magnetic resonance imaging (fMRI) scansResting-state functional connectivityRegional GABA concentrationTerm control groupResonance imaging scansResting-state connectivityRight frontal lobeConcentration of GABANAA/cholineMagnetic resonance spectroscopyPreclinical dataImaging scansFrontal lobeControl groupInfantsBrainMRI dataAgeCerebral Lateralization is Protective in the Very Prematurely Born
Scheinost D, Lacadie C, Vohr BR, Schneider KC, Papademetris X, Constable RT, Ment LR. Cerebral Lateralization is Protective in the Very Prematurely Born. Cerebral Cortex 2014, 25: 1858-1866. PMID: 24451659, PMCID: PMC4459290, DOI: 10.1093/cercor/bht430.Peer-Reviewed Original ResearchConceptsVery preterm participantsPreterm participantsCerebral lateralizationFunctional connectivityPreterm birth altersSevere brain injuryPreterm brainBrain injuryBirth altersTemporal lobeTerm controlsVoxel-based measureDevelopmental delayRight hemisphere lateralizationTerm participantsLateralizationYoung adulthoodSignificant decreaseCerebral asymmetryFurther studiesHemisphere lateralizationLanguage scoresBrainParticipantsAlterations
2012
A left cerebellar pathway mediates language in prematurely-born young adults
Constable RT, Vohr BR, Scheinost D, Benjamin JR, Fulbright RK, Lacadie C, Schneider KC, Katz KH, Zhang H, Papademetris X, Ment LR. A left cerebellar pathway mediates language in prematurely-born young adults. NeuroImage 2012, 64: 371-378. PMID: 22982585, PMCID: PMC3508203, DOI: 10.1016/j.neuroimage.2012.09.008.Peer-Reviewed Original ResearchMeSH KeywordsAgingBrain MappingCerebellumChildConnectomeFemaleHumansInfant, NewbornInfant, PrematureLanguageMaleNerve NetNeural PathwaysYoung AdultConceptsPT subjectsTerm controlsInferior frontal gyrusFunctional MRIFunctional connectivityResting-state functional MRIYoung adultsCognitive outcomesSeed-based connectivity analysisAge 20 yearsSeed-based analysisAlternative neural pathwaysControl young adultsPreterm subjectsCerebellar connectivityNeural pathwaysCerebellar pathwaysIndex scoreNineteen ptsGray matterMaternal educationQuadrangular lobuleDevelopmental delayPT brainSignificant positive correlationThe intrinsic connectivity distribution: A novel contrast measure reflecting voxel level functional connectivity
Scheinost D, Benjamin J, Lacadie CM, Vohr B, Schneider KC, Ment LR, Papademetris X, Constable RT. The intrinsic connectivity distribution: A novel contrast measure reflecting voxel level functional connectivity. NeuroImage 2012, 62: 1510-1519. PMID: 22659477, PMCID: PMC3538880, DOI: 10.1016/j.neuroimage.2012.05.073.Peer-Reviewed Original ResearchConceptsIntrinsic connectivity distributionTerm control subjectsFunctional connectivity differencesControl subjectsVoxel-level functional connectivityConnectivity differencesResting-state fMRIDisease groupTemporal-parietal areasPsychiatric disordersRs-fMRINeurological disordersClinical toolFunctional connectivityYoung adultsFMRI measuresRelevant differencesDisordersSubjectsLanguage processing areasSurvey studyTissue connectivityPretermDifferences