1999
Molecular Evidence for the Early Specification of Presumptive Functional Domains in the Embryonic Primate Cerebral Cortex
Donoghue M, Rakic P. Molecular Evidence for the Early Specification of Presumptive Functional Domains in the Embryonic Primate Cerebral Cortex. Journal Of Neuroscience 1999, 19: 5967-5979. PMID: 10407035, PMCID: PMC6783094, DOI: 10.1523/jneurosci.19-14-05967.1999.Peer-Reviewed Original ResearchConceptsCortical platePresumptive visual cortexPrimate cerebral cortexLigand ephrin-A5Appropriate synaptic connectionsCortical cellsThalamocortical connectionsCerebral cortexMonkey neocortexCortical developmentPrimate neocortexVisual cortexSynaptic connectionsEphrin-A3Ephrin-A2Extrastriate cortexEarly gene expressionEmbryonic neocortexEphrin-A5Molecular patternsNeocortexCortexEphA6Primate corticogenesisPosterior regionThe Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development
Kuan C, Yang D, Roy D, Davis R, Rakic P, Flavell R. The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development. Neuron 1999, 22: 667-676. PMID: 10230788, DOI: 10.1016/s0896-6273(00)80727-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBrainCalcium-Calmodulin-Dependent Protein KinasesCaspasesEmbryonic and Fetal DevelopmentEnzyme ActivationGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicJNK Mitogen-Activated Protein KinasesMiceMice, KnockoutMitogen-Activated Protein Kinase 9Mitogen-Activated Protein KinasesNervous SystemProtein KinasesRhombencephalonConceptsNeural tube closureBrain developmentEmbryonic lethalDouble mutantKinase familyCompound mutantsProtein kinaseCaspase activationPrecocious degenerationJNK2 geneTube closureEarly brain developmentCell deathJNK1Different membersSpecific apoptosisApoptosisMutantsMutant miceJNK2JNK3Mutant forebrainSevere dysregulationFamilyKinaseDistinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex
Anton E, Kreidberg J, Rakic P. Distinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex. Neuron 1999, 22: 277-289. PMID: 10069334, DOI: 10.1016/s0896-6273(00)81089-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDCell AggregationCell MovementCerebral CortexEmbryo, MammalianEmbryonic and Fetal DevelopmentIntegrin alpha3Integrin alpha3beta1Integrin alphaVIntegrinsMiceMutationNeurogliaNeuronsConceptsCerebral cortexNeuronal migrationNeuron-glial interactionsΑv integrin receptorsRadial glial cellsRadial glial fibersCortical neuronsGlial cellsAbnormal layeringLaminar organizationGlial fibersCortexNeuronsSpecific cell-cell recognitionAlpha3beta1 integrinIntegrin receptorsIntegrin geneIntegrinsTargeted mutationsIntegrin functionCorticogenesisReceptorsDevelopment of glomerular synaptic complexes and immunohistochemical differentiation in the superficial dorsal horn of the embryonic primate spinal cord
Knyihar-Csillik E, Rakic P, Csillik B. Development of glomerular synaptic complexes and immunohistochemical differentiation in the superficial dorsal horn of the embryonic primate spinal cord. Brain Structure And Function 1999, 199: 125-148. PMID: 9930620, DOI: 10.1007/s004290050215.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCalcitonin Gene-Related PeptideDendritesEmbryonic and Fetal DevelopmentImmunoenzyme TechniquesMacaca mulattaMicroscopy, ElectronSpinal CordSubstance PSynapsesConceptsSuperficial dorsal hornGlomerular synaptic complexesPrimate spinal cordDorsal hornDorsal root afferentsDorsal root axonsSubstance PSpinal cordSynaptic contactsPrimate dorsal hornSubstantia gelatinosa cellsPrimary afferent terminalsCB-immunoreactive cellsMacaque spinal cordFinal target cellPost-synaptic specializationsCharacteristic cytological featuresGrowth conesPre-embedding immunohistochemistryLaminae IAfferent terminalsImmunohistochemical differentiationGlomerular synapsesAxon terminalsCalcitonin gene
1997
Developmental expression, pattern of distribution, and effect on cell aggregation implicate a neuron‐glial junctional domain protein in neuronal migration
Cameron R, Ruffin J, Cho N, Cameron P, Rakic P. Developmental expression, pattern of distribution, and effect on cell aggregation implicate a neuron‐glial junctional domain protein in neuronal migration. The Journal Of Comparative Neurology 1997, 387: 467-488. PMID: 9373008, DOI: 10.1002/(sici)1096-9861(19971103)387:4<467::aid-cne1>3.0.co;2-0.Peer-Reviewed Original ResearchConceptsRadial glial cellsGlial cellsRadial glial cell processesGlial cell processesMultiple brain regionsNeuronal cell migrationAstrocyte-astrocyteSubventricular zoneImmunofluorescent localization studiesAstroglial cellsNeuron-neuronCerebellar astrocytesBrain regionsMorphologic featuresNeuronal migrationMonoclonal antibodiesImmunoreactivityAntibodiesNeuronsAstrocytesCell migrationPresent studyDevelopmental expressionPattern of distributionCell migration processesEarly divergence of magnocellular and parvocellular functional subsystems in the embryonic primate visual system
Meissirel C, Wikler K, Chalupa L, Rakic P. Early divergence of magnocellular and parvocellular functional subsystems in the embryonic primate visual system. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 5900-5905. PMID: 9159172, PMCID: PMC20878, DOI: 10.1073/pnas.94.11.5900.Peer-Reviewed Original ResearchEarly emergence of photoreceptor mosaicism in the primate retina revealed by a novel cone‐specific monoclonal antibody
Wikler K, Rakic P, Bhattacharyya N, Macleish P. Early emergence of photoreceptor mosaicism in the primate retina revealed by a novel cone‐specific monoclonal antibody. The Journal Of Comparative Neurology 1997, 377: 500-508. PMID: 9007188, DOI: 10.1002/(sici)1096-9861(19970127)377:4<500::aid-cne2>3.0.co;2-6.Peer-Reviewed Original ResearchConceptsPrimate retinaFetal retinaMonoclonal antibodiesAdult primate retinaEmbryonic day 80Opsin-positive conesOuter plexiform layerNovel monoclonal antibodyPopulation of conesShort-wavelength sensitive conesDouble-labeling experimentsSynaptic contactsPlexiform layerPhotoreceptor layerWavelength-sensitive conesMacaque monkeysSynaptic connectionsFetal ageRetinaDay 80Cone genesisCone opsinsImmunoreactivityAntibodiesInitial differentiation
1996
Synaptogenesis in the Occipital Cortex of Macaque Monkey Devoid of Retinal Input From Early Embryonic Stages
Bourgeois J, Rakic P. Synaptogenesis in the Occipital Cortex of Macaque Monkey Devoid of Retinal Input From Early Embryonic Stages. European Journal Of Neuroscience 1996, 8: 942-950. PMID: 8743742, DOI: 10.1111/j.1460-9568.1996.tb01581.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEmbryonic and Fetal DevelopmentEye EnucleationGeniculate BodiesGestational AgeMacaca mulattaNeuronsNeuropeptide YRetinaSynapsesVisual CortexConceptsAge-matched controlsStriate cortexDendritic spinesSynaptic contactsRetinal inputInfragranular cortical layersRatio of synapsesLateral geniculate nucleusPrimate striate cortexVolume of neuropilGroups of animalsEarly embryonic stagesAsymmetrical synapsesInfragranular layersSynaptic organizationGeniculate nucleusOccipital cortexNormal rangeOperated animalsSynaptic circuitsMacaque monkeysCortical layersEnucleated animalsSynaptic developmentDay 67
1995
Neurotransmitter receptors in the proliferative zones of the developing primate occipital lobe
Lidow M, Rakic P. Neurotransmitter receptors in the proliferative zones of the developing primate occipital lobe. The Journal Of Comparative Neurology 1995, 360: 393-402. PMID: 8543647, DOI: 10.1002/cne.903600303.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyCell DivisionEmbryonic and Fetal DevelopmentGestational AgeMacaca mulattaOccipital LobeReceptors, NeurotransmitterConceptsCortical neuronsOccipital lobeReceptor subtypesSubventricular zoneHigh-affinity kainate receptorsProliferative zoneSubventricular proliferative zonesNeurotransmitter receptor subtypesCell proliferationEmbryonic cerebral wallGamma-aminobutyric acidD1 dopaminergicMonkey fetusesDeep laminaeKainate receptorsNeuronal productionCerebral wallMultiple neurotransmittersCortical neurogenesisNeurotransmitter receptorsVisual cortexFetusesNeuronsAlpha 1Alpha 2
1994
Unique profiles of the alpha 1-, alpha 2-, and beta-adrenergic receptors in the developing cortical plate and transient embryonic zones of the rhesus monkey
Lidow, Rakic P. Unique profiles of the alpha 1-, alpha 2-, and beta-adrenergic receptors in the developing cortical plate and transient embryonic zones of the rhesus monkey. Journal Of Neuroscience 1994, 14: 4064-4078. PMID: 8027763, PMCID: PMC6577033, DOI: 10.1523/jneurosci.14-07-04064.1994.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAnimals, NewbornAutoradiographyEmbryonic and Fetal DevelopmentFemaleMacaca mulattaMaleOccipital LobeReceptors, Adrenergic, alphaConceptsTransient embryonic zonesBeta-adrenergic receptorsCortical plateAdrenergic receptor subtypesSubplate zoneReceptor subtypesCerebral wallRhesus monkeysAlpha 1Alpha 1 sitesAlpha 2Alpha 2 receptorsAlpha 1 receptorsEmbryonic zonesIntensive proliferative activityReceptor autoradiographyCortical neuronsSubventricular zoneCortical developmentOccipital lobeBeta receptorsAdrenergic receptorsAdrenergic sitesVisual cortexGerminal zone
1993
Changes of synaptic density in the primary visual cortex of the macaque monkey from fetal to adult stage
Bourgeois J, Rakic P. Changes of synaptic density in the primary visual cortex of the macaque monkey from fetal to adult stage. Journal Of Neuroscience 1993, 13: 2801-2820. PMID: 8331373, PMCID: PMC6576672, DOI: 10.1523/jneurosci.13-07-02801.1993.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsEmbryonic and Fetal DevelopmentFemaleFetusMacaca mulattaMaleMicroscopy, ElectronSexual MaturationSynapsesVisual CortexConceptsPrimary visual cortexSynaptic contactsVisual cortexCortical plateSynaptic densityDendritic spinesPostnatal yearDensity of synapsesThird postnatal monthFirst postnatal yearTime of pubertyMicrons 3Asymmetric synapsesDendritic shaftsLayer VICalcarine fissureCortical neuronsLayer IVPostnatal monthLaminar positionMacaque monkeysFunctional maturationRhesus monkeysAdult levelsNeuropil
1991
A quantitative analysis of synaptogenesis in the molecular layer of the dentate gyrus in the rhesus monkey
Eckenhoff M, Rakic P. A quantitative analysis of synaptogenesis in the molecular layer of the dentate gyrus in the rhesus monkey. Brain Research 1991, 64: 129-135. PMID: 1786637, DOI: 10.1016/0165-3806(91)90216-6.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAnimals, NewbornDendritesEmbryonic and Fetal DevelopmentHippocampusMacaca mulattaMicroscopy, ElectronSynapsesGrowth cone distribution patterns in the optic nerve of fetal monkeys: implications for mechanisms of axon guidance
Williams R, Borodkin M, Rakic P. Growth cone distribution patterns in the optic nerve of fetal monkeys: implications for mechanisms of axon guidance. Journal Of Neuroscience 1991, 11: 1081-1094. PMID: 1901353, PMCID: PMC6575387, DOI: 10.1523/jneurosci.11-04-01081.1991.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsEmbryonic and Fetal DevelopmentFetusHaplorhiniMicroscopy, ElectronOptic NerveRetinal Ganglion CellsConceptsOptic nervePia materGrowth conesMonkey optic nerveGlial end feetPeripheral gradientFetal monkeysEnd feetAxon ingrowthNerveQuantitative electron microscopic methodsPossible associationOlder axonsDay 39Single fasciclePrenatal developmentTemporal edgeBasal laminaFasciclesAxon guidanceAxonsEarly phaseCell generationMonkeysMaterGlial cell lineage in the cerebral cortex: A review and synthesis
Cameron R, Rakic P. Glial cell lineage in the cerebral cortex: A review and synthesis. Glia 1991, 4: 124-137. PMID: 1827774, DOI: 10.1002/glia.440040204.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersCell DifferentiationCerebral CortexEmbryonic and Fetal DevelopmentHumansMammalsNerve Tissue ProteinsNeurogliaNeuronsStem CellsConceptsCerebral cortexCell lineagesCell lineage relationshipsGlial cellsCortical gliogenesisCell-cell interactionsProgenitor cell poolGlial cell lineagesCentral nervous systemLineage relationshipsNervous systemCell poolLineagesGliogenesisCortexPresent reviewFunctional levelCellsPrecise timingDiversityReviewSeries of stepsCerebrum
1990
Axon overproduction and elimination in the corpus callosum of the developing rhesus monkey
LaMantia A, Rakic P. Axon overproduction and elimination in the corpus callosum of the developing rhesus monkey. Journal Of Neuroscience 1990, 10: 2156-2175. PMID: 2376772, PMCID: PMC6570389, DOI: 10.1523/jneurosci.10-07-02156.1990.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAnimals, NewbornAxonsCorpus CallosumEmbryonic and Fetal DevelopmentFetusMacaca mulattaMicroscopy, ElectronNeuronsConceptsCallosal axonsAxon eliminationNewborn monkeysCorpus callosumRhesus monkeysCallosal projection zonePrimate cerebral cortexInterhemispheric projectionsCallosal projectionsCerebral cortexSynaptic densityPostnatal monthPostnatal weekSupernumerary axonsPostnatal eliminationMonkey cortexProjection zonesFetal developmentAdult valuesAxonsLocal proliferationCallosumDay 65BirthMonkeysNeurogenesis of the magnocellular basal forebrain nuclei in the rhesus monkey
Kordower J, Rakic P. Neurogenesis of the magnocellular basal forebrain nuclei in the rhesus monkey. The Journal Of Comparative Neurology 1990, 291: 637-653. PMID: 2329194, DOI: 10.1002/cne.902910410.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyBasal GangliaCell DifferentiationEmbryonic and Fetal DevelopmentGestational AgeMacacaMacaca mulattaThymidineConceptsBasal forebrain nucleiMagnocellular basal forebrain nucleiBasal forebrainForebrain nucleiRhesus monkeysAnterior basal forebrainEmbryonic day 27Early postnatal periodPeak of neurogenesisCortical-cortical connectionsNucleus basalisNeurogenic gradientCortical neuronsDays gestationMagnocellular neuronsPostnatal periodTarget neuronsNeuronal genesisCortical mantleMagnocellular nucleusPregnant animalsDay 27Intermediate divisionGestationPosterior division
1989
Changes in synaptic density in motor cortex of rhesus monkey during fetal and postnatal life
Zecevic N, Bourgeois J, Rakic P. Changes in synaptic density in motor cortex of rhesus monkey during fetal and postnatal life. Brain Research 1989, 50: 11-32. PMID: 2582602, DOI: 10.1016/0165-3806(89)90124-7.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsCell CountEmbryonic and Fetal DevelopmentMacacaMacaca mulattaMotor CortexSynapsesConceptsMotor cortexSynaptic densityCortical plateRhesus monkeysDensity of synapsesTransient subplate zonePrimate motor cortexSecond postnatal monthTime of birthVolume of neuropilMicrons 3Non-human primatesSubplate zoneSymmetric synapsesAsymmetric synapsesDendritic shaftsSynaptic contactsLaminar distributionFirst synapsePostnatal monthDendritic spinesPostnatal lifeSynaptic connectionsAdult levelsCortex
1988
Elimination of neurons from the rhesus monkey's lateral geniculate nucleus during development
Williams R, Rakic P. Elimination of neurons from the rhesus monkey's lateral geniculate nucleus during development. The Journal Of Comparative Neurology 1988, 272: 424-436. PMID: 3417894, DOI: 10.1002/cne.902720310.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CountEmbryonic and Fetal DevelopmentGeniculate BodiesImmunochemistryMacacaMacaca mulattaNerve DegenerationNeuronsConceptsLateral geniculate nucleusGeniculate nucleusDorsal lateral geniculate nucleusDepletion of neuronsElimination of neuronsDays of gestationOcular dominance columnsMonkey lateral geniculate nucleusEmbryonic day 60Geniculocortical connectionsGeniculate neuronsDegenerating neuronsVideo-enhanced differential interference contrast opticsMagnocellular partNeuron eliminationRetinal axonsParvicellular partRetinal cellsRhesus monkeysDay 60Left sideNeuronsNumber of neuronsMiddle thirdDegenerating cells
1971
Guidance of neurons migrating to the fetal monkey neocortex
Rakic P. Guidance of neurons migrating to the fetal monkey neocortex. Brain Research 1971, 33: 471-476. PMID: 5002632, DOI: 10.1016/0006-8993(71)90119-3.Peer-Reviewed Original ResearchAnimalsCerebral CortexCerebral VentriclesEmbryonic and Fetal DevelopmentHaplorhiniMacacaMicroscopy, ElectronNeurogliaNeurons
1968
Development of the corpus callosum and cavum septi in man
Rakic P, Yakovlev P. Development of the corpus callosum and cavum septi in man. The Journal Of Comparative Neurology 1968, 132: 45-72. PMID: 5293999, DOI: 10.1002/cne.901320103.Peer-Reviewed Original Research