2001
Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases
Oppenheim R, Flavell R, Vinsant S, Prevette D, Kuan C, Rakic P. Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases. Journal Of Neuroscience 2001, 21: 4752-4760. PMID: 11425902, PMCID: PMC6762357, DOI: 10.1523/jneurosci.21-13-04752.2001.Peer-Reviewed Original ResearchConceptsCell deathGenetic deletionExtensive cytoplasmic vacuolizationPro-apoptotic proteasesCaspase familySpecific caspasesChromatin condensationNonapoptotic pathwaysPostmitotic neuronsCaspase-9Mammalian neuronsCell typesDeath processSpecific perturbationsCaspase-3Altered morphologyCaspasesNuclear changesKey membersDeletionUTP nickCytoplasmic vacuolizationElectron microscopic levelTerminal deoxynucleotidyl transferase-mediated biotinylated UTP nickNeuronal populations
1999
Illusive transience of parvalbumin expression duringembryonic development of the primate spinal cord
Knyihár‐csillik E, Rakic P, Csillik B. Illusive transience of parvalbumin expression duringembryonic development of the primate spinal cord. International Journal Of Developmental Neuroscience 1999, 17: 79-97. PMID: 10221668, DOI: 10.1016/s0736-5748(98)00090-2.Peer-Reviewed Original ResearchConceptsNerve cellsSpinal cordLarge dorsal root ganglion cellsDorsal root ganglion cellsYoung adult macaque monkeysPrimate spinal cordUpper dorsal hornDorsal root axonsPrimary sensory neuronsSpinal reflex pathwaysElectron microscopic immunohistochemical techniquesAdult macaque monkeysParvalbumin-positive terminalsLong axonal processesDorsal hornMonkey fetusesDorsal columnsReflex pathwaysGanglion cellsClarke's nucleusAxon terminalsIntercellular networkMotoneuron poolSensory neuronsSynaptic terminalsDevelopment of glomerular synaptic complexes and immunohistochemical differentiation in the superficial dorsal horn of the embryonic primate spinal cord
Knyihar-Csillik E, Rakic P, Csillik B. Development of glomerular synaptic complexes and immunohistochemical differentiation in the superficial dorsal horn of the embryonic primate spinal cord. Brain Structure And Function 1999, 199: 125-148. PMID: 9930620, DOI: 10.1007/s004290050215.Peer-Reviewed Original ResearchConceptsSuperficial dorsal hornGlomerular synaptic complexesPrimate spinal cordDorsal hornDorsal root afferentsDorsal root axonsSubstance PSpinal cordSynaptic contactsPrimate dorsal hornSubstantia gelatinosa cellsPrimary afferent terminalsCB-immunoreactive cellsMacaque spinal cordFinal target cellPost-synaptic specializationsCharacteristic cytological featuresGrowth conesPre-embedding immunohistochemistryLaminae IAfferent terminalsImmunohistochemical differentiationGlomerular synapsesAxon terminalsCalcitonin gene
1997
Developmental expression, pattern of distribution, and effect on cell aggregation implicate a neuron‐glial junctional domain protein in neuronal migration
Cameron R, Ruffin J, Cho N, Cameron P, Rakic P. Developmental expression, pattern of distribution, and effect on cell aggregation implicate a neuron‐glial junctional domain protein in neuronal migration. The Journal Of Comparative Neurology 1997, 387: 467-488. PMID: 9373008, DOI: 10.1002/(sici)1096-9861(19971103)387:4<467::aid-cne1>3.0.co;2-0.Peer-Reviewed Original ResearchConceptsRadial glial cellsGlial cellsRadial glial cell processesGlial cell processesMultiple brain regionsNeuronal cell migrationAstrocyte-astrocyteSubventricular zoneImmunofluorescent localization studiesAstroglial cellsNeuron-neuronCerebellar astrocytesBrain regionsMorphologic featuresNeuronal migrationMonoclonal antibodiesImmunoreactivityAntibodiesNeuronsAstrocytesCell migrationPresent studyDevelopmental expressionPattern of distributionCell migration processesDorsal root origin of axonal growth cones: regenerative synapto-neogenesis in the upper spinal dorsal horn of primates.
Knyihár-Csillik E, Seres L, Rakic P, Csillik B. Dorsal root origin of axonal growth cones: regenerative synapto-neogenesis in the upper spinal dorsal horn of primates. Ideggyógyászati Szemle 1997, 5: 481-8. PMID: 9591285.Peer-Reviewed Original Research
1995
Structure of the embryonic primate spinal cord at the closure of the first reflex arc
Knyihar-Csillik E, Csillik B, Rakic P. Structure of the embryonic primate spinal cord at the closure of the first reflex arc. Brain Structure And Function 1995, 191: 519-540. PMID: 7677259, DOI: 10.1007/bf00186742.Peer-Reviewed Original ResearchConceptsPrimate spinal cordReflex arcSpinal cordSpinal reflex arcAlar plateDay gestation periodAssociation interneuronsProximal dendritesAxon collateralsMotoneuronal somataFirst synapsesNeuronal perikaryaGlial cellsAfferent impulsesNumerous synapsesGolgi impregnationAssociation fibersBasal plateAxonal pathwaysAssociation neuronsCordNerve impulsesTarget cellsSynapsesCellular mechanisms
1989
Transneuronal degeneration in the Rolando substance of the primate spinal cord evoked by axotomy-induced transganglionic degenerative atrophy of central primary sensory terminals
Knyihár-Csillik E, Rakic P, Csillik B. Transneuronal degeneration in the Rolando substance of the primate spinal cord evoked by axotomy-induced transganglionic degenerative atrophy of central primary sensory terminals. Cell And Tissue Research 1989, 258: 515-525. PMID: 2611858, DOI: 10.1007/bf00218863.Peer-Reviewed Original ResearchConceptsTransganglionic degenerative atrophyTransneuronal degenerationDegenerative atrophyMild formPrimary sensory terminalsPrimate spinal cordSubstantia gelatinosa cellsUpper dorsal hornSG cellsDorsal hornSpinothalamic tractPrimary afferentsAfferent activityInnocuous inputsRolando substanceSciatic nerveSynaptic relationshipsSpinal cordProjection cellsSynaptic glomeruliSensory terminalsSevere degenerationSevere formDendritic processesCentral terminals
1987
Transganglionic degenerative atrophy in the substantia gelatinosa of the spinal cord after peripheral nerve transection in rhesus monkeys
Knyihár-Csillik E, Rakic P, Csillik B. Transganglionic degenerative atrophy in the substantia gelatinosa of the spinal cord after peripheral nerve transection in rhesus monkeys. Cell And Tissue Research 1987, 247: 599-604. PMID: 3568105, DOI: 10.1007/bf00215754.Peer-Reviewed Original ResearchConceptsTransganglionic degenerative atrophyNerve transectionSubstantia gelatinosaDegenerative atrophySpinal cordUpper dorsal hornPeripheral nerve injurySciatic nerve transectionPeripheral nerve transectionDiverse cellular changesDorsal hornNerve injuryDorsal rootsWallerian degenerationNociceptive systemGlial elementsSchwann cellsAdult rhesusRhesus monkeysCellular changesSynaptic vesiclesAtrophyTransectionCordGelatinosa
1985
Fine structure of growth cones in the upper dorsal horn of the adult primate spinal cord in the course of reactive synapto-neogenesis
Knyihár-Csillik E, Rakic P, Csillik B. Fine structure of growth cones in the upper dorsal horn of the adult primate spinal cord in the course of reactive synapto-neogenesis. Cell And Tissue Research 1985, 239: 633-641. PMID: 2580631, DOI: 10.1007/bf00219242.Peer-Reviewed Original ResearchConceptsUpper dorsal hornDendritic growth conesSpinal cordDorsal hornAxonal growth conesGrowth conesPrimate spinal cordTransganglionic degenerative atrophyLumbar spinal cordPrimary afferent terminalsImmature synapsesAfferent terminalsSciatic nerveDegenerative atrophyCNS regenerationGrowth cone vesiclesAxoplasmic reticulumPreterminal portionsCordMacacus rhesusRegenerative processesMembrane specializationsElectron microscopic structureHornAtrophy
1982
Ultrastructure of normal and degenerating glomerular terminals of dorsal root axons in the substantia gelatinosa of the rhesus monkey
Knyihar‐Csillik E, Csillik B, Rakic P. Ultrastructure of normal and degenerating glomerular terminals of dorsal root axons in the substantia gelatinosa of the rhesus monkey. The Journal Of Comparative Neurology 1982, 210: 357-375. PMID: 7142447, DOI: 10.1002/cne.902100404.Peer-Reviewed Original ResearchConceptsPrimary sensory terminalsDorsal root axonsLamina IIClear synaptic vesiclesSynaptic vesiclesSensory terminalsRhesus monkeysDorsal root transectionDorsal root fibersEmpty synaptic vesiclesAdult rhesus monkeysSynaptic vesicle populationDense-core vesiclesDeep collateralsDorsal hornRoot transectionSubstantia gelatinosaDorsal rootsPrimary afferentsGlomerular terminalsSpinal cordAxon terminalsGlial cellsPosterior hornDegeneration patternsPeriterminal synaptology of dorsal root glomerular terminals in the substantia gelatinosa of the spinal cord in the rhesus monkey
Knyigar‐Csillik E, Csillik B, Rakic P. Periterminal synaptology of dorsal root glomerular terminals in the substantia gelatinosa of the spinal cord in the rhesus monkey. The Journal Of Comparative Neurology 1982, 210: 376-399. PMID: 7142448, DOI: 10.1002/cne.902100405.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDendritesFemaleGanglia, SpinalMacaca mulattaMaleModels, NeurologicalSpinal CordSynapsesConceptsSubstantia gelatinosa cellsPresynaptic dendritesSubstantia gelatinosaGlomerular terminalsSpinal cordF-boutonsGlomerular complexRhesus monkeysPrimate central nervous systemPrimary afferent impulsesPrimary sensory terminalsCentral nervous systemDorsal root terminalsAdult rhesus monkeysNociceptive informationPostsynaptic modulationPrimary afferentsAdjacent glomeruliPostsynaptic dendritesSynaptic organizationTransganglionic degenerative atrophy and regenerative proliferation in the Rolando substance of the primate spinal cord: discoupling and restoration of synaptic connectivity in the central nervous system after peripheral nerve lesions.
Csillik B, Knyihár E, Rakic P. Transganglionic degenerative atrophy and regenerative proliferation in the Rolando substance of the primate spinal cord: discoupling and restoration of synaptic connectivity in the central nervous system after peripheral nerve lesions. Functional And Developmental Morphology 1982, 30: 189-91. PMID: 7118007.Peer-Reviewed Original Research
1980
Immunoperoxidase localization of glial fibrillary acidic protein in radial glial cells and astrocytes of the developing rhesus monkey brain
Levitt P, Rakic P. Immunoperoxidase localization of glial fibrillary acidic protein in radial glial cells and astrocytes of the developing rhesus monkey brain. The Journal Of Comparative Neurology 1980, 193: 815-840. PMID: 7002963, DOI: 10.1002/cne.901930316.Peer-Reviewed Original ResearchConceptsGlial fibrillary acidic proteinRadial glial cellsGlial cellsFibrillary acidic proteinBergmann glial cellsGlial fibersNeuronal elementsPial surfacePeroxidase-antiperoxidase immunohistochemical stainingAcidic proteinNeuronal migrationEmbryonic day 38Rhesus monkey brainSecond postnatal monthCentral nervous systemHorseradish peroxidase reaction productRadial fibersSpinal cordPostnatal monthBergmann glial fibersSubventricular zoneImmunohistochemical stainingAstroglial cellsCerebellar cortexImmunohistochemical localization
1978
Transient Synapses in the Embryonic Primate Spinal Cord
Knyihar E, Csillik B, Rakic P. Transient Synapses in the Embryonic Primate Spinal Cord. Science 1978, 202: 1206-1209. PMID: 103200, DOI: 10.1126/science.103200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCell SurvivalDendritesGestational AgeHaplorhiniMacaca mulattaSpinal CordSynapses
1968
Supravital DNA synthesis in the developing human and mouse brain.
RAKIC P, SIDMAN R. Supravital DNA synthesis in the developing human and mouse brain. Journal Of Neuropathology & Experimental Neurology 1968, 27: 246-76. PMID: 5646196, DOI: 10.1097/00005072-196804000-00006.Peer-Reviewed Original Research