2022
Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex
Rash B, Arellano J, Duque A, Rakic P. Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 120: e2210967120. PMID: 36574666, PMCID: PMC9910595, DOI: 10.1073/pnas.2210967120.Peer-Reviewed Original ResearchConceptsOuter subventricular zoneSubcortical white matterCerebral cortexWhite matterFormation of gyriPrimate cerebral cortexMammalian cerebral cortexMarkers of proliferationCortical malformationsCortical plateGlial cellsGyral developmentSubventricular zoneCortical neurogenesisFetal developmentVentricular zoneCortical foldingNeuronal progenitorsGyrificationNeuronal growthNeuropil growthPrimary gyriCortexNeurodevelopmental disordersGyrus
1999
Distinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex
Anton E, Kreidberg J, Rakic P. Distinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex. Neuron 1999, 22: 277-289. PMID: 10069334, DOI: 10.1016/s0896-6273(00)81089-2.Peer-Reviewed Original ResearchConceptsCerebral cortexNeuronal migrationNeuron-glial interactionsΑv integrin receptorsRadial glial cellsRadial glial fibersCortical neuronsGlial cellsAbnormal layeringLaminar organizationGlial fibersCortexNeuronsSpecific cell-cell recognitionAlpha3beta1 integrinIntegrin receptorsIntegrin geneIntegrinsTargeted mutationsIntegrin functionCorticogenesisReceptors
1997
Developmental expression, pattern of distribution, and effect on cell aggregation implicate a neuron‐glial junctional domain protein in neuronal migration
Cameron R, Ruffin J, Cho N, Cameron P, Rakic P. Developmental expression, pattern of distribution, and effect on cell aggregation implicate a neuron‐glial junctional domain protein in neuronal migration. The Journal Of Comparative Neurology 1997, 387: 467-488. PMID: 9373008, DOI: 10.1002/(sici)1096-9861(19971103)387:4<467::aid-cne1>3.0.co;2-0.Peer-Reviewed Original ResearchConceptsRadial glial cellsGlial cellsRadial glial cell processesGlial cell processesMultiple brain regionsNeuronal cell migrationAstrocyte-astrocyteSubventricular zoneImmunofluorescent localization studiesAstroglial cellsNeuron-neuronCerebellar astrocytesBrain regionsMorphologic featuresNeuronal migrationMonoclonal antibodiesImmunoreactivityAntibodiesNeuronsAstrocytesCell migrationPresent studyDevelopmental expressionPattern of distributionCell migration processesRole of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex.
Anton E, Marchionni M, Lee K, Rakic P. Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex. Development 1997, 124: 3501-10. PMID: 9342043, DOI: 10.1242/dev.124.18.3501.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCell CommunicationCell MovementCerebral CortexCulture TechniquesFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsGlycoproteinsNerve Growth FactorsNerve Tissue ProteinsNeuregulinsNeurogliaNeuronsRatsRats, Sprague-DawleyReceptor, ErbB-2Receptors, Nerve Growth FactorSignal TransductionConceptsRadial glial developmentRadial glial cellsBrain lipid-binding proteinCerebral cortexGlial cellsNeuronal migrationGlial developmentRadial glial cell functionGlial growth factorGlial cell functionRadial glial fibersRadial glial fiber systemNeuronal cell migrationCortical neuronsGlial interactionsRadial gliaGlial fibersGlial moleculesCortexNeuronsGrowth factorErbB2 receptorCell functionDependent mannerCell migration
1995
Structure of the embryonic primate spinal cord at the closure of the first reflex arc
Knyihar-Csillik E, Csillik B, Rakic P. Structure of the embryonic primate spinal cord at the closure of the first reflex arc. Brain Structure And Function 1995, 191: 519-540. PMID: 7677259, DOI: 10.1007/bf00186742.Peer-Reviewed Original ResearchConceptsPrimate spinal cordReflex arcSpinal cordSpinal reflex arcAlar plateDay gestation periodAssociation interneuronsProximal dendritesAxon collateralsMotoneuronal somataFirst synapsesNeuronal perikaryaGlial cellsAfferent impulsesNumerous synapsesGolgi impregnationAssociation fibersBasal plateAxonal pathwaysAssociation neuronsCordNerve impulsesTarget cellsSynapsesCellular mechanisms
1994
Identification of membrane proteins that comprise the plasmalemmal junction between migrating neurons and radial glial cells
Cameron R, Rakic P. Identification of membrane proteins that comprise the plasmalemmal junction between migrating neurons and radial glial cells. Journal Of Neuroscience 1994, 14: 3139-3155. PMID: 8182462, PMCID: PMC6577439, DOI: 10.1523/jneurosci.14-05-03139.1994.Peer-Reviewed Original ResearchConceptsRadial glial cellsGlial cellsMembrane proteinsCell-cell recognitionFocal adhesion plaquesApparent molecular massRadial glial cell processesNeuronal cell migrationCerebellar glial cellsActin cytoskeletonGlial cell processesMicrotubule cytoskeletonNon-neural tissuesSurface microdomainsMembrane polypeptidesIndividual proteinsAdhesion plaquesProcess-bearing astrocytesIntact microtubulesAdult stageMolecular massCell migrationMigration eventsIntegrin subunitsJunctional complexes
1991
Glial cell lineage in the cerebral cortex: A review and synthesis
Cameron R, Rakic P. Glial cell lineage in the cerebral cortex: A review and synthesis. Glia 1991, 4: 124-137. PMID: 1827774, DOI: 10.1002/glia.440040204.Peer-Reviewed Original ResearchConceptsCerebral cortexCell lineagesCell lineage relationshipsGlial cellsCortical gliogenesisCell-cell interactionsProgenitor cell poolGlial cell lineagesCentral nervous systemLineage relationshipsNervous systemCell poolLineagesGliogenesisCortexPresent reviewFunctional levelCellsPrecise timingDiversityReviewSeries of stepsCerebrum
1990
Developmental history of the transient subplate zone in the visual and somatosensory cortex of the macaque monkey and human brain
Kostovic I, Rakic P. Developmental history of the transient subplate zone in the visual and somatosensory cortex of the macaque monkey and human brain. The Journal Of Comparative Neurology 1990, 297: 441-470. PMID: 2398142, DOI: 10.1002/cne.902970309.Peer-Reviewed Original ResearchConceptsSubplate zoneTransient subplate zoneCortical plateSomatosensory cortexSubcortical white matterSubplate neuronsBasal forebrainBrain stemContralateral cerebralGlial cellsPostmigratory neuronsSomatosensory areaFetal brainOccipital lobeCerebral convolutionsCerebral wallFiber terminalsHuman fetusesWhite matterMacaque monkeysVisual areasCortexGestationFiber-rich layersHistochemical methods
1989
GABAA/benzodiazepine receptor-like immunoreactivity in rat and monkey cerebellum
Meinecke D, Tallman J, Rakic P. GABAA/benzodiazepine receptor-like immunoreactivity in rat and monkey cerebellum. Brain Research 1989, 493: 303-319. PMID: 2548668, DOI: 10.1016/0006-8993(89)91165-7.Peer-Reviewed Original ResearchConceptsReceptor-like immunoreactivityGABAA/benzodiazepine receptorGolgi type II cellsType II cellsAxon terminalsBasket cellsBenzodiazepine receptorsCerebellar cortexCortical layersII cellsMonkey cerebellumUnlabeled axon terminalsCytoplasm of neuronsMossy fiber terminalsDeep cerebellar nucleiImmunoreactive dendritesSymmetric synapsesImmunostained neuronsInhibitory circuitsLabel neuronsGlial cellsNeuronal typesFiber terminalsGranule cellsStellate cells
1988
Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey
Eckenhoff M, Rakic P. Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey. Journal Of Neuroscience 1988, 8: 2729-2747. PMID: 3411351, PMCID: PMC6569394, DOI: 10.1523/jneurosci.08-08-02729.1988.Peer-Reviewed Original ResearchConceptsProliferative cellsMitotic divisionPostmitotic cellsUltra-structural characteristicsPossible functionsElectron microscopic levelStable populationGlial fibrillary acidic proteinNeuronal cellsStem cellsJuvenile periodMajor classesMature primatesSubgranular zoneDentate gyrusGlial cellsLife spanCellsGFAP-negative cellsFateRhesus monkeysAcidic proteinNew neuronsPostpubertal animalsFibrillary acidic protein
1985
Localization of γ-aminobutyric acid and glutamic acid decarboxylase in rhesus monkey retina
Nishimura Y, Schwartz M, Rakic P. Localization of γ-aminobutyric acid and glutamic acid decarboxylase in rhesus monkey retina. Brain Research 1985, 359: 351-355. PMID: 3907753, DOI: 10.1016/0006-8993(85)91449-0.Peer-Reviewed Original ResearchConceptsGlutamic acid decarboxylaseGamma-aminobutyric acidAcid decarboxylaseRhesus monkey retinaGanglion cell layerOuter plexiform layerScleral halfΓ-aminobutyric acidMonkey retinaPlexiform layerUse of antiseraGlial cellsMüller cellsHorizontal cellsRhesus monkeysNeuronal processesReactive bandsSubclass of cellsCell layerImmunoreactive bandsOne-thirdRetinaCellsAmacrineDecarboxylaseDNA Synthesis and Cell Division in the Adult Primate Braina
RAKIC P. DNA Synthesis and Cell Division in the Adult Primate Braina. Annals Of The New York Academy Of Sciences 1985, 457: 193-211. PMID: 3913364, DOI: 10.1111/j.1749-6632.1985.tb20806.x.Peer-Reviewed Original ResearchConceptsPostembryonic neurogenesisNonmammalian vertebratesCell divisionDNA precursorsPrimate central nervous systemStable populationDNA synthesisNonprimate mammalsCentral nervous systemMature primatesNeuronal additionGlial cellsNervous systemAdult monkeysRetention of memoryAutoradiographic analysisMultiple injectionsVertebratesDevelopmental periodMammalsVariable degreesNeuronsJuvenilesNeurogenesisTurnoverLimits of Neurogenesis in Primates
Rakic P. Limits of Neurogenesis in Primates. Science 1985, 227: 1054-1056. PMID: 3975601, DOI: 10.1126/science.3975601.Peer-Reviewed Original Research
1984
Cytodifferentiation and synaptogenesis in the neostriatum of fetal and neonatal rhesus monkeys
Brand S, Rakic P. Cytodifferentiation and synaptogenesis in the neostriatum of fetal and neonatal rhesus monkeys. Brain Structure And Function 1984, 169: 21-34. PMID: 6721218, DOI: 10.1007/bf00300583.Peer-Reviewed Original ResearchConceptsSynaptic densityDendritic shaftsFetal monthAsymmetric synapsesRhesus monkeysPostnatal rhesus monkeysNeonatal rhesus monkeysRound clear vesiclesFirst postnatal monthNeuronal cell bodiesShafts of dendritesGolgi impregnation methodEmbryonic day 60Axospinous synapsesSymmetric synapsesPresynaptic profilesPleomorphic vesiclesGlial cellsPostnatal monthAxonal profilesCaudate nucleusDendritic processesPostnatal developmentClear vesiclesCell bodiesEmergence of Neuronal and Glial Cell Lineages in Primate Brain
Rakic P. Emergence of Neuronal and Glial Cell Lineages in Primate Brain. 1984, 29-50. DOI: 10.1007/978-1-4613-2717-2_2.Peer-Reviewed Original ResearchMammalian brainGlial cellsGlial cell lineagesCell lineagesNeural tubeGlial lineagesNeuronal cellsCellular mechanismsMajority of cellsNeuronal-glial interactionsCell linesLineagesPrimitive neural tubeCellsYoung neuronsFunctional abnormalitiesPrimate brainImportant roleBrainCompartmentalizationNeuronsDivergenceRegulationNeuroepitheliumNeuronal
1982
Ultrastructure of normal and degenerating glomerular terminals of dorsal root axons in the substantia gelatinosa of the rhesus monkey
Knyihar‐Csillik E, Csillik B, Rakic P. Ultrastructure of normal and degenerating glomerular terminals of dorsal root axons in the substantia gelatinosa of the rhesus monkey. The Journal Of Comparative Neurology 1982, 210: 357-375. PMID: 7142447, DOI: 10.1002/cne.902100404.Peer-Reviewed Original ResearchConceptsPrimary sensory terminalsDorsal root axonsLamina IIClear synaptic vesiclesSynaptic vesiclesSensory terminalsRhesus monkeysDorsal root transectionDorsal root fibersEmpty synaptic vesiclesAdult rhesus monkeysSynaptic vesicle populationDense-core vesiclesDeep collateralsDorsal hornRoot transectionSubstantia gelatinosaDorsal rootsPrimary afferentsGlomerular terminalsSpinal cordAxon terminalsGlial cellsPosterior hornDegeneration patternsThe Role of Neuronal-Glial Cell Interaction During Brain Development
Rakic P. The Role of Neuronal-Glial Cell Interaction During Brain Development. Dahlem Workshop Report 1982, 25-38. DOI: 10.1007/978-3-642-68466-1_4.Peer-Reviewed Original ResearchRadial glial cellsGlial cellsNeuronal-glial cell interactionsGlial-specific markersGlial cell classesRecent immunocytochemical studiesSite of originBrain abnormalitiesSynaptic terminalsGlial precursorsNervous systemPrimate brainGlial fibersImmunocytochemical studyBrain developmentDifferentiating neuronsCell classesBrain surfaceDegenerating cellsSpecific markersVentricular surfaceCellular mechanismsProliferative zonePossible involvementNormal developmental processesOntogeny State of the Art Report
Strichartz G, Aguayo A, Cowan W, Distel H, Lim L, McKhann G, Mugnaini E, Rakic P, Rickmann M, Spitzer N, Webster H. Ontogeny State of the Art Report. Dahlem Workshop Report 1982, 93-114. DOI: 10.1007/978-3-642-68466-1_9.Peer-Reviewed Original Research
1981
Neuronal-glial interaction during brain development
Rakic P. Neuronal-glial interaction during brain development. Trends In Neurosciences 1981, 4: 184-187. DOI: 10.1016/0166-2236(81)90060-6.Peer-Reviewed Original ResearchRadial glial cellsGlial cellsNeuronal-glial interactionsGlial cell classesPositioning of neuronsPeak of neurogenesisRecent immunocytochemical studiesImmature neuronsCerebellar cortexPrimate brainImmunocytochemical studyBrain developmentCell precursorsCell classesSpecific markersNeuronsNeuron tissueElectron microscopic analysisCellsNeurogenesisCortexBrainCoexistence of neuronal and glial precursor cells in the cerebral ventricular zone of the fetal monkey: an ultrastructural immunoperoxidase analysis
Levitt P, Cooper M, Rakic P. Coexistence of neuronal and glial precursor cells in the cerebral ventricular zone of the fetal monkey: an ultrastructural immunoperoxidase analysis. Journal Of Neuroscience 1981, 1: 27-39. PMID: 7050307, PMCID: PMC6564162, DOI: 10.1523/jneurosci.01-01-00027.1981.Peer-Reviewed Original ResearchConceptsGlial fibrillary acid proteinLast cell divisionCell divisionRadial glial cellsNeuronal cell lineAcid proteinCerebral ventricular zoneEmbryonic day 80Proliferative zoneGlial precursor cellsMitotic cycleCell typesPeak of neurogenesisPrecursor cellsCell linesVentricular zoneElectron microscopic levelFetal monkeysProliferative cellsGlial cellsSubventricular zoneOccipital lobePhenotypic expressionCytological compositionDistinct classes