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Faculty & Researchers

  • MingDe Lin

    Assistant Professor Adjunct, Radiology & Biomedical Imaging

    Dr. Lin received the B.S. degree from Rensselaer Polytechnic Institute and the Ph.D. degree from Duke University, all in biomedical engineering. He is currently the Director for Clinical Research in North America for Visage Imaging and is stationed at Yale-New Haven Hospital where he oversees, coordinates, drives and directs research collaborations with high profile academic hospitals in North America to develop new solutions for diagnostic image analysis and guidance that improve clinical and operational outcomes while reducing cost of care. This includes activities in Artificial Intelligence (AI) and Machine Learning (ML) in the Radiology enterprise diagnostic imaging solutions space. Dr. Lin identifies opportunities for academic-industry research partnerships, and acts as the liaison between Visage Imaging researchers and clinical collaborators to translate ideas to prototype for clinical validation, with the goal of technology transfer to product. Dr. Lin also is directly involved in research to develop better ways to treat patients with liver cancer using transcatheter arterial chemoembolization (TACE) and in this context, he is also the chief engineer and operations manager of the Yale Interventional Oncology Research Lab. Dr. Lin is the Principle Investigator (PI) on two NIH R01 grants to improve the diagnosis, treatment, and response assessment after transcatheter arterial chemoembolization for patients with liver cancer. Dr. Lin is the inventor of 3D quantification TACE therapy response tool (qEASL) and in collaboration with clinical partners, validated, and showed clinical relevance (ability to predict patient survival) that led to transfer to commercial product (FDA 510(k) approved December 2016 - Multi-Modality Tumor Tracking (MMTT) application). Prior to Visage Imaging, Dr. Lin was the Philips research site manager and senior researcher stationed onsite at Yale where he managed the research portfolio and partnership Philips has with Yale.

  • Julius Chapiro

    Associate Research Scientist in Radiology and Biomedical Imaging; Resident in Radiology and Biomedical Imaging

    Dr. Chapiro joined the Department of Radiology and Biomedical Imaging as a research scientist and interventional radiology resident from Berlin, Germany. After graduating from the University of Leipzig and upon completion of his research thesis at the Justus-Liebig University in Giessen with summa cum laude, he served as a postdoctoral research fellow in interventional oncology at The Johns Hopkins Hospital and then as radiology resident at the Department of Radiology, Charité University Hospital in Berlin.

    Dr. Chapiro’s research focuses on developing new quantitative imaging biomarkers for the diagnosis, characterization, and therapeutic management of liver cancer. His translational research portfolio includes the development of novel embolic agents as well as the application of artificial intelligence solutions for the management of liver cancer. His basic research interest mainly focuses on developing new tools to characterize the tumor microenvironment and the immune system in the setting of loco-regional, image-guided therapies of liver cancer.

    Creating innovative and clinically applicable imaging solutions for liver cancer with advanced molecular imaging, image post-processing and machine learning approaches and translating them to clinical practice has been his central mission for the past five years. He authored and co-authored >60 original research articles, numerous reviews and book chapters and gave more than 50 talks and invited lectures within the last four years. His research has also resulted in several filed patent applications, 510(k)-approved medical products and significant grant support from federal, foundational and industry sources. He is an active research mentor to more than 30 undergraduate, medical and graduate students as well as peers both at Yale and other national and international institutions. Being an active contributor, journal-, abstract- and grant reviewer in several professional societies (RSNA, SIR and SIO), he is also committed to education and the mission of disseminating research data and scientific knowledge. Dr. Chapiro is a member of the ACR Liver Imaging Reporting and Data System (LI-RADS) Steering Committee, he additionally serves on the SIO Research Committee and is Co-Track Chair of the Interventional Oncology meeting program at the annual RSNA meeting since 2017. He is the co-initiator of the "Rising Star" Student Exchange Program in collaboration with the Charité University Hospital in Berlin and co-manages the Yale Radiology Research laboratory.

  • Eliot Funai

    Research Associate

    Eliot Funai graduated from the University of Maryland, Baltimore County, and previously worked at Johns Hopkins University before coming to Yale. His work as a clinical research coordinator is to develop and oversee the management and execution of clinical trials, primarily concerning locoregional therapies for treating liver cancers. His experience is with investigator initiated studies, industry and NIH-funded trials, and cooperative group studies.

  • Edvin Isufi

    Clinical Fellow

    Edvin Isufi is a native of Albania and received his medical degree from University of Medicine of Tirana in 2001. He completed his 4 years of residency training in Radiology at the "Mother Teresa" University Hospital of Tirana in 2008. His focus during the residency was interventional radiology. His plan for the future is getting into radiology residency and certified from the American Board of Radiology. Dr. Isufi joined the radiology research lab as a Visiting Research Scientist, participating on different clinical trials, primarily concerning trans-catheter loco-regional therapies. His research project now is the effect of transarterial chemoembolization therapy of liver metastasis from lung cancer.

  • Ahmet Kücükkaya

    Postgraduate Fellow

    Ahmet is a 3rd-year medical student from Charité University Hospital Berlin in Germany and joined the Interventional Oncology Research Lab in February 2020. 

    He's taking part in the research of our Lab within the “Rising Star“ Research Exchange Program between the Yale School of Medicine and the Charité University Hospital in Berlin. 

    He is a fellow of the Avicenna Scholarship Foundation (Avicenna-Studienwerk) and received a travel grant from the Rolf W. Günther Foundation for Radiological Sciences.

    His current research is based on finding a Machine Learning model for predicting the recurrence-risk of HCC patients after treatment

  • Alexandra Petukhova

    Postgraduate Fellow

    Alexandra Petukhova joined the Department of Radiology and Biomedical Imaging at Yale in February 2019 as a Postgraduate Associate within the “Rising Star” Research Exchange Program between the Charité University Hospital Berlin, Germany and the Yale School of Medicine. Alexandra is a 4th-year medical student at the Charité University Hospital Berlin and received a travel grant from the Rolf W. Günther Foundation for Radiological Sciences. 

    Alexandra’s current research at Yale focuses on the assessment of clinical and imaging features of hepatocellular carcinoma (HCC) and the characterization of biomarkers to optimize the diagnosis, stratification and staging of HCC patients.

    Further, Alexandra investigates the interactions between the tumor cells and immune cells such as macrophages and t-cells in the local microenvironment of liver cancer in an immunogenic mice model.  

  • Jessica Santana

    Postgraduate Associate

    Jessica received her Master’s degree in Biomedical Sciences with a focus on cancer development and immune responses from Radboud Universiteit in the Netherlands. She concluded her program at the Department of Immunobiology at Yale through the Radboud University Medical Center Study Fund and travel grant for traineeship abroad. She recently joined the Department of Radiology and Biomedical Imaging as a Postgraduate Fellow, where she is working with animal models for molecular characterization of the tumor microenvironment to loco-reginal therapies in liver cancer from an imaging perspective. 

      She received her B.S in Biomedical Sciences from the Universidade Estadual de Santa Cruz, Brazil, with further research experience from Harvard School of Public Health, USA, and Mcgill University, Canada, through the Science Without Borders Scholarship Program

  • Fabian Laage Gaupp

    Hospital Resident

    Fabian joined our group as a first year radiology resident in 2016, after having completed his surgical intern year at Cornell. His current work includes evaluation of a novel imaging technique to visualize tumor hypoxia and acidity noninvasively in a rabbit liver tumor model after transarterial chemoembolization. He plans to specialize in interventional radiology and is particularly interested in how combining ultrasound with CT and MRI can be used to guide surgical and interventional procedures more accurately.

  • Brian Letzen

    Hospital Resident; Integrated IR/DR Residency, Radiology & Biomedical Imaging

    Brian Letzen received his M.D. degree from the Yale School of Medicine, where he continues as an interventional/diagnostic radiology resident. He graduated with a master’s degree in biomedical engineering from the Johns Hopkins University and with a bachelor’s degree in electrical engineering from the University of Florida. In the past, he has worked in engineering at GE Healthcare and Oak Ridge National Laboratory. His overall research interests involve clinical, translational, and basic science innovations to provide cancer patients with the least invasive approaches to diagnosis, treatment, and surveillance - incorporating "big data" and artificial intelligence. He received a RSNA Research Resident Grant to develop a novel liver diagnosis tool using deep machine learning techniques. Additionally, he is currently investigating innovations in intra-operative cone beam CT for transarterial chemoembolization of liver tumors.

  • Evan Chen

    Medical Student

    Evan is a first year medical student at the Yale School of Medicine. He is working on a retrospective study that evaluates the efficacy of intra-arterial in liver cancer patients. The long-term goal of this study is to help inform future clinical decisions and improve outcomes of patients with liver cancer.
  • Arash Fereydooni

    Medical Student

    Arash received his B.S. and M.S. degrees from Yale University in Molecular, Cellular and Developmental Biology in 2015. He is currently a medical student at Yale School of Medicine and a researcher at the Radiology Research Group. His basic science research at Forscher Lab was funded by several fellowships and investigated focal adhesion dynamic and traction force in neuronal cells. Currently his clinical research is focused on assessing safety-profile and response after image-guided liver cancer therapies. He hopes to enter a speciality centered on minimally invasive procedures.
  • Mansur Ghani

    Medical Student

    Mansur Ghani is a third year medical student at Yale School of Medicine. Since joining the group in 2015, Mansur's work has involved predicting response to treatment of HCC to intra-arterial therapy and investigating staging biomarkers for colorectal cancer metastases to the liver. He currently holds a BS in Molecular Biophysics and Biochemistry from Yale College, and plans to apply for residency programs in interventional radiology.
  • Stephen Ghazikhanian

    Medical Student

    Stephen is a medical student at Yale School of Medicine. His current research with the lab assesses different image analysis algorithms and their ability to classify viable tumor and necrosis in the context of HCC. He received his BS in Neuroscience from Duke University in 2016.
  • Moritz Gross

    Moritz Gross joined the Yale Interventional Oncology Research Lab in October 2019 as a Postgraduate Associate within the “Rising Star” Research Exchange Program in collaboration with the Charité University Berlin, where he is a 4th-year medical student.

    His current research at the Yale Interventional Oncology Research Lab focuses on Machine Learning.

    For his travel to Yale, he received a travel grant from the Rolf W. Günther Foundation for Radiological Sciences.

    Moreover, he is part of the Noninvasive Imaging Heisenberg Research Group of Prof. Dr. Marc Dewey at Charité in Berlin, where he is researching on noninvasive cardiovascular imaging research.

  • Nikitha Murali

    Medical Student

    Nikitha Murali is a medical student at Yale School of Medicine. Her research interests include the application of statistical and machine learning techniques to medical imaging. She received her BA from the University of Chicago in 2015 and worked for a healthcare technology company prior to joining Yale.
  • Marley Windham-Herman

    Medical Student

    Medical Student at Yale School of Medicine. Studied Neurobiology, Physiology, and Behavior in his home state at the University of California, Davis. Research experience in interventional radiology, diagnostic radiology, and addiction medicine. Currently investigating the effects of intra-arterial embolic therapies such as chemoembolization, drug-eluting bead embolization, and radioembolization in the treatment of hepatocellular carcinoma and metastatic liver tumors. Other ongoing research includes investigation of the role of multiparametric MRI in the diagnosis of prostate cancer.