Yale Interventional Oncology Research Lab Publications

2022

Translating artificial intelligence from code to bedside: The road towards AI-driven predictive biomarkers for immunotherapy of hepatocellular carcinoma.Chapiro J. J Hepatol. 2022 Jul; 2022 Apr 10. PMID: 35417743.
Optimization of the BCLC Staging System for Locoregional Therapy for Hepatocellular Carcinoma by Using Quantitative Tumor Burden Imaging Biomarkers at MRI.Borde T, Nezami N, Laage Gaupp F, Savic LJ, Taddei T, Jaffe A, Strazzabosco M, Lin M, Duran R, Georgiades C, Hong K, Chapiro J. Radiology. 2022 Jul; 2022 Apr 12. PMID: 35412368.
Machine Learning Tools for Image-Based Glioma Grading and the Quality of Their Reporting: Challenges and Opportunities.Merkaj S, Bahar RC, Zeevi T, Lin M, Ikuta I, Bousabarah K, Cassinelli Petersen GI, Staib L, Payabvash S, Mongan JT, Cha S, Aboian MS. Cancers (Basel). 2022 May 25; 2022 May 25. PMID: 35681603.
Machine Learning Models for Classifying High- and Low-Grade Gliomas: A Systematic Review and Quality of Reporting Analysis.Bahar RC, Merkaj S, Cassinelli Petersen GI, Tillmanns N, Subramanian H, Brim WR, Zeevi T, Staib L, Kazarian E, Lin M, Bousabarah K, Huttner AJ, Pala A, Payabvash S, Ivanidze J, Cui J, Malhotra A, Aboian MS. Front Oncol. 2022; 2022 Apr 22. PMID: 35530302.
Cryoablation of Venous Malformations: A Systematic Review.Fish A, Moushey A, Chan SM, Staib L, Marino A, Schlachter T. J Vasc Interv Radiol. 2022 Apr 22; 2022 Apr 22. PMID: 35469956.
MR Imaging Biomarkers for the Prediction of Outcome after Radiofrequency Ablation of Hepatocellular Carcinoma: Qualitative and Quantitative Assessments of the Liver Imaging Reporting and Data System and Radiomic Features.Petukhova-Greenstein A, Zeevi T, Yang J, Chai N, DiDomenico P, Deng Y, Ciarleglio M, Haider SP, Onyiuke I, Malpani R, Lin M, Kucukkaya AS, Gottwald LA, Gebauer B, Revzin M, Onofrey J, Staib L, Gunabushanam G, Taddei T, Chapiro J. J Vasc Interv Radiol. 2022 Apr 20; 2022 Apr 20. PMID: 35460887.
What's Needed to Bridge the Gap Between US FDA Clearance and Real-world Use of AI Algorithms.Lin M. Acad Radiol. 2022 Apr; 2021 Nov 20. PMID: 34794879.
Comparison of metabolic and immunologic responses to transarterial chemoembolization with different chemoembolic regimens in a rabbit VX2 liver tumor model.Doemel LA, Santana JG, Savic LJ, Gaupp FML, Borde T, Petukhova-Greenstein A, Kucukkaya AS, Schobert IT, Hamm CA, Gebauer B, Walsh JJ, Rexha I, Hyder F, Lin M, Madoff DC, Schlachter T, Chapiro J, Coman D. Eur Radiol. 2022 Apr; 2021 Oct 31. PMID: 34718844.
Impact of Chemoembolic Regimen on Immune Cell Recruitment and Immune Checkpoint Marker Expression following Transcatheter Arterial Chemoembolization in a VX2 Rabbit Liver Tumor Model.Berz AM, Santana JG, Iseke S, Gross M, Pekurovsky V, Laage Gaupp F, Savic LJ, Borde T, Gottwald LA, Boustani AM, Gebauer B, Lin M, Zhang X, Schlachter T, Madoff DC, Chapiro J. J Vasc Interv Radiol. 2022 Mar 26; 2022 Mar 26. PMID: 35346859.
Machine Learning Applications for Differentiation of Glioma from Brain Metastasis-A Systematic Review.Jekel L, Brim WR, von Reppert M, Staib L, Cassinelli Petersen G, Merkaj S, Subramanian H, Zeevi T, Payabvash S, Bousabarah K, Lin M, Cui J, Brackett A, Mahajan A, Omuro A, Johnson MH, Chiang VL, Malhotra A, Scheffler B, Aboian MS. Cancers (Basel). 2022 Mar 8; 2022 Mar 8. PMID: 35326526.
Quantitative Automated Segmentation of Lipiodol Deposits on Cone-Beam CT Imaging Acquired during Transarterial Chemoembolization for Liver Tumors: A Deep Learning Approach.Malpani R, Petty CW, Yang J, Bhatt N, Zeevi T, Chockalingam V, Raju R, Petukhova-Greenstein A, Santana JG, Schlachter TR, Madoff DC, Chapiro J, Duncan J, Lin M. J Vasc Interv Radiol. 2022 Mar; 2021 Dec 16. PMID: 34923098.
Direct and indirect strategies of deep-learning-based attenuation correction for general purpose and dedicated cardiac SPECT.Chen X, Zhou B, Xie H, Shi L, Liu H, Holler W, Lin M, Liu YH, Miller EJ, Sinusas AJ, Liu C. Eur J Nucl Med Mol Imaging. 2022 Feb 16; 2022 Feb 16. PMID: 35169887.
Artificial intelligence in liver diseases: Improving diagnostics, prognostics and response prediction.Nam D, Chapiro J, Paradis V, Seraphin TP, Kather JN. JHEP Rep. 2022 Apr; 2022 Feb 2. PMID: 35243281.

2021

Identifying enhancement-based staging markers on baseline MRI in patients with colorectal cancer liver metastases undergoing intra-arterial tumor therapy.Ghani MA, Fereydooni A, Chen E, Letzen B, Laage-Gaupp F, Nezami N, Deng Y, Gan G, Thakur V, Lin M, Papademetris X, Schernthaner RE, Huber S, Chapiro J, Hong K, Georgiades C. Eur Radiol. 2021 Dec; 2021 Jun 1. PMID: 34061209.
Improved performance and consistency of deep learning 3D liver segmentation with heterogeneous cancer stages in magnetic resonance imaging.Gross M, Spektor M, Jaffe A, Kucukkaya AS, Iseke S, Haider SP, Strazzabosco M, Chapiro J, Onofrey JA. PLoS One. 2021; 2021 Dec 1. PMID: 34852007.
Consensus Guidelines for the Definition of Time-to-Event End Points in Image-guided Tumor Ablation: Results of the SIO and DATECAN Initiative.Puijk RS, Ahmed M, Adam A, Arai Y, Arellano R, de Baère T, Bale R, Bellera C, Binkert CA, Brace CL, Breen DJ, Brountzos E, Callstrom MR, Carrafiello G, Chapiro J, de Cobelli F, Coupé VMH, Crocetti L, Denys A, Dupuy DE, Erinjeri JP, Filippiadis D, Gangi A, Gervais DA, Gillams AR, Greene T, Guiu B, Helmberger T, Iezzi R, Kang TW, Kelekis A, Kim HS, Kröncke T, Kwan S, Lee MW, Lee FT, Lee EW Jr, Liang P, Lissenberg-Witte BI, Lu DS, Madoff DC, Mauri G, Meloni MF, Morgan R, Nadolski G, Narayanan G, Newton I, Nikolic B, Orsi F, Pereira PL, Pua U, Rhim H, Ricke J, Rilling W, Salem R, Scheffer HJ, Sofocleous CT, Solbiati LA, Solomon SB, Soulen MC, Sze D, Uberoi R, Vogl TJ, Wang DS, Wood BJ, Goldberg SN, Meijerink MR. Radiology. 2021 Dec; 2021 Sep 28. PMID: 34581627.
Longitudinal Analysis of the Effect of Repeated Transarterial Chemoembolization for Liver Cancer on Portal Venous Pressure.Frangakis C, Sohn JH, Bas A, Chapiro J, Schernthaner RE, Lin M, Hamilton JP, Pawlik TM, Hong K, Duran R. Front Oncol. 2021; 2021 Nov 5. PMID: 34804911.
Lipiodol Deposition and Washout in Primary and Metastatic Liver Tumors After Chemoembolization.Nezami N, VAN Breugel JMM, Konstantinidis M, Chapiro J, Savic LJ, Miszczuk MA, Rexha I, Lin M, Hong K, Georgiades C. In Vivo. 2021 Nov-Dec. PMID: 34697157.
Machine Learning-Based Surveillance Strategy after Complete Ablation of Initially Recurrent Hepatocellular Carcinoma: Worth the Risk?Nam D, Chapiro J. J Vasc Interv Radiol. 2021 Nov. PMID: 34717834.
Incidence of Spontaneous Pulmonary AVM Rupture in HHT Patients.Fish A, Henderson K, Moushey A, Pollak J, Schlachter T. J Clin Med. 2021 Oct 14; 2021 Oct 14. PMID: 34682838.
Lipiodol as an intra-procedural imaging biomarker for liver tumor response to transarterial chemoembolization: Post-hoc analysis of a prospective clinical trial.Letzen BS, Malpani R, Miszczuk M, de Ruiter QMB, Petty CW, Rexha I, Nezami N, Laage-Gaupp F, Lin M, Schlachter TR, Chapiro J. Clin Imaging. 2021 Oct; 2021 May 18. PMID: 34022765.
How COVID-19 kick-started online learning in medical education-The DigiMed study.Stoehr F, Müller L, Brady A, Trilla A, Mähringer-Kunz A, Hahn F, Düber C, Becker N, Wörns MA, Chapiro J, Hinrichs JB, Akata D, Ellmann S, Huisman M, Koff D, Brinkmann S, Bamberg F, Zimmermann O, Traikova NI, Marquardt JU, Chang DH, Rengier F, Auer TA, Emrich T, Muehler F, Schmidberger H, Baeßler B, Dos Santos DP, Kloeckner R. PLoS One. 2021; 2021 Sep 21. PMID: 34547031.
Quantitative volumetric assessment of baseline enhancing tumor volume as an imaging biomarker predicts overall survival in patients with glioblastoma.Auer TA, Della Seta M, Collettini F, Chapiro J, Zschaeck S, Ghadjar P, Badakhshi H, Florange J, Hamm B, Budach V, Kaul D. Acta Radiol. 2021 Sep; 2020 Sep 16. PMID: 32938221.
Hepatic Radiofrequency Ablation: Monitoring of Ablation-Induced Macrophage Recruitment in the Periablational Rim Using SPION-Enhanced Macrophage-Specific Magnetic Resonance Imaging.Collettini F, Brangsch J, Reimann C, Chapiro J, Savic LJ, Buchholz R, Keller S, Hamm B, Goldberg SN, Makowski MR. Invest Radiol. 2021 Sep 1. PMID: 33787536.
Thermal ablation alone vs thermal ablation combined with transarterial chemoembolization for patients with small (<3 cm) hepatocellular carcinoma.Chai NX, Chapiro J, Petukhova A, Gross M, Kucukkaya A, Raju R, Zeevi T, Elbanan M, Lin M, Perez-Lozada JC, Schlachter T, Strazzabosco M, Pollak JS, Madoff DC. Clin Imaging. 2021 Aug; 2021 Feb 11. PMID: 33592550.
Deep learning-assisted differentiation of pathologically proven atypical and typical hepatocellular carcinoma (HCC) versus non-HCC on contrast-enhanced MRI of the liver.Oestmann PM, Wang CJ, Savic LJ, Hamm CA, Stark S, Schobert I, Gebauer B, Schlachter T, Lin M, Weinreb JC, Batra R, Mulligan D, Zhang X, Duncan JS, Chapiro J. Eur Radiol. 2021 Jul; 2021 Jan 6. PMID: 33409782.
Cost-Effectiveness of Imaging Tumor Response Criteria in Hepatocellular Cancer After Transarterial Chemoembolization.Wu X, Chapiro J, Malhotra A. J Am Coll Radiol. 2021 Jul; 2021 Jan 20. PMID: 33484726.
Anatomy-guided multimodal registration by learning segmentation without ground truth: Application to intraprocedural CBCT/MR liver segmentation and registration.Zhou B, Augenfeld Z, Chapiro J, Zhou SK, Liu C, Duncan JS. Med Image Anal. 2021 Jul; 2021 Mar 21. PMID: 33823397.
Reliable prediction of survival in advanced-stage hepatocellular carcinoma treated with sorafenib: comparing 1D and 3D quantitative tumor response criteria on MRI.Doemel LA, Chapiro J, Laage Gaupp F, Savic LJ, Kucukkaya AS, Petukhova A, Tefera J, Zeevi T, Lin M, Schlachter T, Jaffe A, Strazzabosco M, Patel T, Stein SM. Eur Radiol. 2021 May; 2020 Oct 30. PMID: 33123796.
Prospective study of Lipiodol distribution as an imaging marker for doxorubicin pharmacokinetics during conventional transarterial chemoembolization of liver malignancies.Savic LJ, Chapiro J, Funai E, Bousabarah K, Schobert IT, Isufi E, Geschwind JH, Stark S, He P, Rudek MA, Perez Lozada JC, Ayyagari R, Pollak J, Schlachter T. Eur Radiol. 2021 May; 2020 Oct 15. PMID: 33063185.
Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma.Rexha I, Laage-Gaupp F, Chapiro J, Miszczuk MA, van Breugel JMM, Lin M, Konstantinidis M, Duran R, Gebauer B, Georgiades C, Hong K, Nezami N. Sci Rep. 2021 Apr 29; 2021 Apr 29. PMID: 33927226.
Elastin-specific MRI of extracellular matrix-remodelling following hepatic radiofrequency-ablation in a VX2 liver tumor model.Collettini F, Reimann C, Brangsch J, Chapiro J, Savic LJ, Onthank DC, Robinson SP, Karst U, Buchholz R, Keller S, Hamm B, Goldberg SN, Makowski MR. Sci Rep. 2021 Mar 25; 2021 Mar 25. PMID: 33767303.
Automated detection and delineation of hepatocellular carcinoma on multiphasic contrast-enhanced MRI using deep learning.Bousabarah K, Letzen B, Tefera J, Savic L, Schobert I, Schlachter T, Staib LH, Kocher M, Chapiro J, Lin M. Abdom Radiol (NY). 2021 Jan; 2020 Jun 4. PMID: 32500237.
Use of Artificial Intelligence in Non-Oncologic Interventional Radiology: Current State and Future Directions.Malpani R, Petty CW, Bhatt N, Staib LH, Chapiro J. Dig Dis Interv. 2021; 2021 Jul 17. PMID: 35005333.
Fibronodular hepatocellular carcinoma-a new variant of liver cancer: clinical, pathological and radiological correlation.Tefera J, Revzin M, Chapiro J, Savic LJ, Mulligan D, Batra R, Taddei T, Jain D, Zhang X. J Clin Pathol. 2021 Jan; 2020 May 19. PMID: 32430483.
Comparison of Drug-Eluting Embolics versus Conventional Transarterial Chemoembolization for the Treatment of Patients with Unresectable Hepatocellular Carcinoma: A Cost-Effectiveness Analysis.Wu X, Chapiro J, Malhotra A, Kothary N. J Vasc Interv Radiol. 2021 Jan; 2020 Nov 5. PMID: 33160827.

2020

Quantification of contrast-uptake as imaging biomarker for disease progression of renal cell carcinoma after tumor ablation.Tegel BR, Huber S, Savic LJ, Lin M, Gebauer B, Pollak J, Chapiro J. Acta Radiol. 2020 Dec; 2020 Mar 26. PMID: 32216452.
Therapy of Intermediate-Stage Hepatocellular Carcinoma: Current Evidence and Clinical Practice.Chai NX, Chapiro J. Semin Intervent Radiol. 2020 Dec; 2020 Dec 11. PMID: 33328701.
Automated feature quantification of Lipiodol as imaging biomarker to predict therapeutic efficacy of conventional transarterial chemoembolization of liver cancer.Stark S, Wang C, Savic LJ, Letzen B, Schobert I, Miszczuk M, Murali N, Oestmann P, Gebauer B, Lin M, Duncan J, Schlachter T, Chapiro J. Sci Rep. 2020 Oct 22; 2020 Oct 22. PMID: 33093524.
Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as predictors of tumor response in hepatocellular carcinoma after DEB-TACE.Schobert IT, Savic LJ, Chapiro J, Bousabarah K, Chen E, Laage-Gaupp F, Tefera J, Nezami N, Lin M, Pollak J, Schlachter T. Eur Radiol. 2020 Oct; 2020 May 19. PMID: 32424595.
Idarubicin-Loaded ONCOZENE Drug-Eluting Bead Chemoembolization in a Rabbit Liver Tumor Model: Investigating Safety, Therapeutic Efficacy, and Effects on Tumor Microenvironment.Borde T, Laage Gaupp F, Geschwind JF, Savic LJ, Miszczuk M, Rexha I, Adam L, Walsh JJ, Huber S, Duncan JS, Peters DC, Sinusas A, Schlachter T, Gebauer B, Hyder F, Coman D, van Breugel JMM, Chapiro J. J Vasc Interv Radiol. 2020 Oct; 2020 Jul 17. PMID: 32684417.
Predicting Infiltrative Hepatocellular Carcinoma Patient Outcome Post-TACE: MR Bias Field Correction Effect on 3D-quantitative Image Analysis.Liu C, Smolka S, Papademetris X, Minh DD, Gan G, Deng Y, Lin M, Chapiro J, Wang X, Georgiades C, Hong K. J Clin Transl Hepatol. 2020 Sep 28; 2020 Aug 18. PMID: 33083252.
Quantitative MRI for Assessment of Treatment Outcomes in a Rabbit VX2 Hepatic Tumor Model.Keller S, Chapiro J, Brangsch J, Reimann C, Collettini F, Sack I, Savic LJ, Hamm B, Goldberg SN, Makowski M. J Magn Reson Imaging. 2020 Sep; 2019 Nov 12. PMID: 31713973.
Molecular MRI of the Immuno-Metabolic Interplay in a Rabbit Liver Tumor Model: A Biomarker for Resistance Mechanisms in Tumor-targeted Therapy?Savic LJ, Doemel LA, Schobert IT, Montgomery RR, Joshi N, Walsh JJ, Santana J, Pekurovsky V, Zhang X, Lin M, Adam L, Boustani A, Duncan J, Leng L, Bucala RJ, Goldberg SN, Hyder F, Coman D, Chapiro J. Radiology. 2020 Sep; 2020 Jul 7. PMID: 32633675.
Extracellular pH mapping of liver cancer on a clinical 3T MRI scanner.Coman D, Peters DC, Walsh JJ, Savic LJ, Huber S, Sinusas AJ, Lin M, Chapiro J, Constable RT, Rothman DL, Duncan JS, Hyder F. Magn Reson Med. 2020 May; 2019 Nov 5. PMID: 31691371.
Supervised Machine Learning in Oncology: A Clinician's Guide.Murali N, Kucukkaya A, Petukhova A, Onofrey J, Chapiro J. Dig Dis Interv. 2020 Mar. PMID: 32869010.
Comparing HCC arterial tumour vascularisation on baseline imaging and after lipiodol cTACE: how do estimations of enhancing tumour volumes differ on contrast-enhanced MR and CT?Luedemann WM, Geisel D, Gebauer B, Schnapauff D, Chapiro J, Wieners G, Steffen I, Kahn J. Eur Radiol. 2020 Mar; 2019 Dec 6. PMID: 31811428.
Lipiodol as an Imaging Biomarker of Tumor Response After Conventional Transarterial Chemoembolization: Prospective Clinical Validation in Patients with Primary and Secondary Liver Cancer.Miszczuk MA, Chapiro J, Geschwind JH, Thakur V, Nezami N, Laage-Gaupp F, Kulon M, van Breugel JMM, Fereydooni A, Lin M, Savic LJ, Tegel B, Wahlin T, Funai E, Schlachter T. Transl Oncol. 2020 Mar; 2020 Feb 22. PMID: 32092672.
Prostatic Artery Embolization in Nonindex Benign Prostatic Hyperplasia Patients: Single-center Outcomes for Urinary Retention and Gross Prostatic Hematuria.Ayyagari R, Powell T, Staib L, Chapiro J, Perez-Lozada JC, Bhatia S, Chai T, Schoenberger S, Devito R. Urology. 2020 Feb; 2019 Nov 14. PMID: 31734349.
Molecular Imaging of Extracellular Tumor pH to Reveal Effects of Locoregional Therapy on Liver Cancer Microenvironment.Savic LJ, Schobert IT, Peters D, Walsh JJ, Laage-Gaupp FM, Hamm CA, Tritz N, Doemel LA, Lin M, Sinusas A, Schlachter T, Duncan JS, Hyder F, Coman D, Chapiro J. Clin Cancer Res. 2020 Jan 15; 2019 Oct 3. PMID: 31582517.
Accelerating the Translation of Artificial Intelligence From Ideas to Routine Clinical Workflow.Lin M. Acad Radiol. 2020 Jan. PMID: 31818377.
Prostatic Artery Embolization Using 100-300-μm Trisacryl Gelatin Microspheres to Treat Lower Urinary Tract Symptoms Attributable to Benign Prostatic Hyperplasia: A Single-Center Outcomes Analysis with Medium-Term Follow-up.Ayyagari R, Powell T, Staib L, Chapiro J, Raja A, Bhatia S, Chai T, Schoenberger S, Devito R. J Vasc Interv Radiol. 2020 Jan; 2019 Nov 23. PMID: 31771896.

2019

Interventional oncology: aiming globally to be the 4th pillar of cancer care.Madoff DC, Chapiro J, Pua U. Chin Clin Oncol. 2019 Dec. PMID: 31968980.
A 3D quantitative imaging biomarker in pre-treatment MRI predicts overall survival after stereotactic radiation therapy of patients with a singular brain metastasis.Della Seta M, Collettini F, Chapiro J, Angelidis A, Engeling F, Hamm B, Kaul D. Acta Radiol. 2019 Nov; 2019 Mar 6. PMID: 30841703.
Cholangiolithiasis postliver transplantation: Successful treatment utilizing percutaneous transhepatic cholangioscopy and laser lithotripsy.Nezami N, Benchetrit L, Latich I, Schlachter T. Radiol Case Rep. 2019 Dec; 2019 Oct 8. PMID: 31641393.
Domain-Agnostic Learning with Anatomy-Consistent Embedding for Cross-Modality Liver Segmentation.Yang J, Dvornek NC, Zhang F, Zhuang J, Chapiro J, Lin M, Duncan JS. IEEE Int Conf Comput Vis Workshops. 2019 Oct; 2020 Mar 5. PMID: 34676308.
Unsupervised Domain Adaptation via Disentangled Representations: Application to Cross-Modality Liver Segmentation.Yang J, Dvornek NC, Zhang F, Chapiro J, Lin M, Duncan JS. Med Image Comput Comput Assist Interv. 2019 Oct; 2019 Oct 10. PMID: 32377643.
Fluorodeoxyglucose PET for Monitoring Response to Embolotherapy (Transarterial Chemoembolization) in Primary and Metastatic Liver Tumors.Schobert I, Chapiro J, Pucar D, Saperstein L, Savic LJ. PET Clin. 2019 Oct; 2019 Aug 7. PMID: 31472741.
From Code to Bedside: Introducing Predictive Intelligence to Interventional Oncology.Chapiro J, Duncan JS. Radiol Artif Intell. 2019 Sep 25; 2019 Sep 25. PMID: 32076661.
Case-Control Comparison of Conventional End-Hole versus Balloon-Occlusion Microcatheter Prostatic Artery Embolization for Treatment of Symptomatic Benign Prostatic Hyperplasia.Ayyagari R, Powell T, Staib L, Chapiro J, Schoenberger S, Devito R, Pollak J. J Vasc Interv Radiol. 2019 Sep; 2019 Jul 30. PMID: 31375451.
Quantitative Imaging Biomarkers for ⁹⁰Y Distribution on Bremsstrahlung SPECT After Resin-Based Radioembolization.Schobert I, Chapiro J, Nezami N, Hamm CA, Gebauer B, Lin M, Pollak J, Saperstein L, Schlachter T, Savic LJ. J Nucl Med. 2019 Aug; 2019 Jan 17. PMID: 30655331.
Deep learning for liver tumor diagnosis part II: convolutional neural network interpretation using radiologic imaging features.Wang CJ, Hamm CA, Savic LJ, Ferrante M, Schobert I, Schlachter T, Lin M, Weinreb JC, Duncan JS, Chapiro J, Letzen B. Eur Radiol. 2019 Jul; 2019 May 15. PMID: 31093705.
Deep learning for liver tumor diagnosis part I: development of a convolutional neural network classifier for multi-phasic MRI.Hamm CA, Wang CJ, Savic LJ, Ferrante M, Schobert I, Schlachter T, Lin M, Duncan JS, Weinreb JC, Chapiro J, Letzen B. Eur Radiol. 2019 Jul; 2019 Apr 23. PMID: 31016442.
Immunotherapy and the Interventional Oncologist: Challenges and Opportunities-A Society of Interventional Oncology White Paper.Erinjeri JP, Fine GC, Adema GJ, Ahmed M, Chapiro J, den Brok M, Duran R, Hunt SJ, Johnson DT, Ricke J, Sze DY, Toskich BB, Wood BJ, Woodrum D, Goldberg SN. Radiology. 2019 Jul; 2019 Apr 23. PMID: 31012818.
Theranostic application of lipiodol for transarterial chemoembolization in a VX2 rabbit liver tumor model.van Breugel JMM, Geschwind JF, Mirpour S, Savic LJ, Zhang X, Duran R, Lin M, Miszczuk M, Liapi E, Chapiro J. Theranostics. 2019; 2019 May 27. PMID: 31281506.
The Role of Artificial Intelligence in Interventional Oncology: A Primer.Letzen B, Wang CJ, Chapiro J. J Vasc Interv Radiol. 2019 Jan; 2018 Dec 7. PMID: 30528289.

2018

Irinotecan-Eluting 75-150-μm Embolics Lobar Chemoembolization in Patients with Colorectal Cancer Liver Metastases: A Prospective Single-Center Phase I Study.Fereydooni A, Letzen B, Ghani MA, Miszczuk MA, Huber S, Chapiro J, Schlachter T, Geschwind JF, Georgiades C. J Vasc Interv Radiol. 2018 Dec; 2018 Oct 15. PMID: 30337148.
Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma.Abajian A, Murali N, Savic LJ, Laage-Gaupp FM, Nezami N, Duncan JS, Schlachter T, Lin M, Geschwind JF, Chapiro J. J Vis Exp. 2018 Oct 10; 2018 Oct 10. PMID: 30371657.
Liver Tissue Classification Using an Auto-context-based Deep Neural Network with a Multi-phase Training Framework.Zhang F, Yang J, Nezami N, Laage-Gaupp F, Chapiro J, De Lin M, Duncan J. Patch Based Tech Med Imaging (2018). 2018 Sep; 2018 Sep 15. PMID: 32432233.
Clinical Experience with Real-Time 3-D Guidance Based on C-Arm-Acquired Cone-Beam CT (CBCT) in Transjugular Intrahepatic Portosystemic Stent Shunt (TIPSS) Placement.Böning G, Lüdemann WM, Chapiro J, Jonczyk M, Hamm B, Günther RW, Gebauer B, Streitparth F. Cardiovasc Intervent Radiol. 2018 Jul; 2018 Mar 14. PMID: 29541837.
Predicting Treatment Response to Intra-arterial Therapies for Hepatocellular Carcinoma with the Use of Supervised Machine Learning-An Artificial Intelligence Concept.Abajian A, Murali N, Savic LJ, Laage-Gaupp FM, Nezami N, Duncan JS, Schlachter T, Lin M, Geschwind JF, Chapiro J. J Vasc Interv Radiol. 2018 Jun; 2018 Mar 14. PMID: 29548875.
Characteristics of a New X-Ray Imaging System for Interventional Procedures: Improved Image Quality and Reduced Radiation Dose.Schernthaner RE, Haroun RR, Nguyen S, Duran R, Sohn JH, Sahu S, Chapiro J, Zhao Y, Radaelli A, van der Bom IM, Mauti M, Hong K, Geschwind JH, Lin M. Cardiovasc Intervent Radiol. 2018 Mar; 2017 Oct 31. PMID: 29090348.
Which Criteria Applied in Multi-Phasic CT Can Predict Early Tumor Response in Patients with Hepatocellular Carcinoma Treated Using Conventional TACE: RECIST, mRECIST, EASL or qEASL?Zhao Y, Duran R, Bai W, Sahu S, Wang W, Kabus S, Lin M, Han G, Geschwind JF. Cardiovasc Intervent Radiol. 2018 Mar; 2017 Oct 30. PMID: 29086058.
C-Arm Cone Beam CT for Intraprocedural Image Fusion and 3D Guidance in Portal Vein Embolization (PVE).Lüdemann WM, Böning G, Chapiro J, Jonczyk M, Geisel D, Schnapauff D, Wieners G, Schmelzle M, Chopra S, Günther RW, Gebauer B, Streitparth F. Cardiovasc Intervent Radiol. 2018 Mar; 2017 Sep 5. PMID: 28875339.
Sensitivity and Reproducibility of Automated Feeding Artery Detection Software during Transarterial Chemoembolization of Hepatocellular Carcinoma.Chiaradia M, Izamis ML, Radaelli A, Prevoo W, Maleux G, Schlachter T, Mayer J, Luciani A, Kobeiter H, Tacher V. J Vasc Interv Radiol. 2018 Mar; 2018 Feb 3. PMID: 29402612.
Science to Practice: Decrypting the Enigma of Ablation-induced Off-Target Effects-Is Network Pathway Analysis the Final Piece of the Puzzle?Murali N, Laage-Gaupp FM, Chapiro J, Geschwind JF. Radiology. 2018 Feb. PMID: 29356646.

2017

Intra-arterial therapy of neuroendocrine tumour liver metastases: comparing conventional TACE, drug-eluting beads TACE and yttrium-90 radioembolisation as treatment options using a propensity score analysis model.Do Minh D, Chapiro J, Gorodetski B, Huang Q, Liu C, Smolka S, Savic LJ, Wainstejn D, Lin M, Schlachter T, Gebauer B, Geschwind JF. Eur Radiol. 2017 Dec; 2017 Jul 4. PMID: 28677067.
Science to Practice: Molecular-targeted Drug Delivery in Combination with Radiofrequency Ablation of Liver Cancer: A Magic Bullet?Adam LC, Murali N, Chapiro J, Geschwind JF. Radiology. 2017 Nov. PMID: 29045226.
Liver tissue classification in patients with hepatocellular carcinoma by fusing structured and rotationally invariant context representation.Treilhard J, Smolka S, Staib L, Chapiro J, Lin M, Shakirin G, Duncan J. Med Image Comput Comput Assist Interv. 2017 Sep; 2017 Sep 4. PMID: 29900427.
Science to Practice: Killing Dormant Cells-Is Targeting Autophagy the Key to Complete Tumor Response in Transarterial Chemoembolization?Savic LJ, Chapiro J, Geschwind JF. Radiology. 2017 Jun. PMID: 28514219.
Imaging Biomarkers of Tumor Response in Neuroendocrine Liver Metastases Treated with Transarterial Chemoembolization: Can Enhancing Tumor Burden of the Whole Liver Help Predict Patient Survival?Sahu S, Schernthaner R, Ardon R, Chapiro J, Zhao Y, Sohn JH, Fleckenstein F, Lin M, Geschwind JF, Duran R. Radiology. 2017 Jun; 2016 Nov 10. PMID: 27831830.
Validation of the Hong Kong Liver Cancer Staging System in Determining Prognosis of the North American Patients Following Intra-arterial Therapy.Sohn JH, Duran R, Zhao Y, Fleckenstein F, Chapiro J, Sahu S, Schernthaner RE, Qian T, Lee H, Zhao L, Hamilton J, Frangakis C, Lin M, Salem R, Geschwind JF. Clin Gastroenterol Hepatol. 2017 May; 2016 Nov 12. PMID: 27847278.
Advanced-stage hepatocellular carcinoma with portal vein thrombosis: conventional versus drug-eluting beads transcatheter arterial chemoembolization.Gorodetski B, Chapiro J, Schernthaner R, Duran R, Lin M, Lee H, Lenis D, Stuart EA, Nonyane BA, Pekurovsky V, Tamrazi A, Gebauer B, Schlachter T, Pawlik TM, Geschwind JF. Eur Radiol. 2017 Feb; 2016 Jun 8. PMID: 27277261.
Intra-arterial therapies for liver cancer: assessing tumor response.Stroehl YW, Letzen BS, van Breugel JM, Geschwind JF, Chapiro J. Expert Rev Anticancer Ther. 2017 Feb; 2016 Dec 27. PMID: 27983883.
Intra-arterial embolotherapy for intrahepatic cholangiocarcinoma: update and future prospects.Savic LJ, Chapiro J, Geschwind JH. Hepatobiliary Surg Nutr. 2017 Feb. PMID: 28261591.
Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer.Duran R, Mirpour S, Pekurovsky V, Ganapathy-Kanniappan S, Brayton CF, Cornish TC, Gorodetski B, Reyes J, Chapiro J, Schernthaner RE, Frangakis C, Lin M, Sun JD, Hart CP, Geschwind JF. Clin Cancer Res. 2017 Jan 15; 2016 Jul 20. PMID: 27440271.
The impact of antiangiogenic therapy combined with Transarterial Chemoembolization on enhancement based quantitative tumor response assessment in patients with hepatocellular carcinoma.Smolka S, Chapiro J, Manzano W, Treilhard J, Reiner E, Deng Y, Zhao Y, Hamm B, Duncan JS, Gebauer B, Lin M, Geschwind JF. Clin Imaging. 2017 Nov - Dec; 2017 Jun 7. PMID: 28668723.

2016

Transarterial Chemoembolization for the Treatment of Advanced-Stage Hepatocellular Carcinoma.Zhao Y, Duran R, Chapiro J, Sohn JH, Sahu S, Fleckenstein F, Smolka S, Pawlik TM, Schernthaner R, Zhao L, Lee H, He S, Lin M, Geschwind JF. J Gastrointest Surg. 2016 Dec; 2016 Oct 6. PMID: 27714643.
Interventional Oncology in Hepatocellular Carcinoma: Progress Through Innovation.Mu L, Chapiro J, Stringam J, Geschwind JF. Cancer J. 2016 Nov/Dec. PMID: 27870678.
From the Guest Editor: Interventional Oncology: The Fourth Pillar of Oncology.Kim HS, Chapiro J, Geschwind JH. Cancer J. 2016 Nov/Dec. PMID: 27870677.
Improved Visibility of Metastatic Disease in the Liver During Intra-Arterial Therapy Using Delayed Arterial Phase Cone-Beam CT.Schernthaner RE, Haroun RR, Duran R, Lee H, Sahu S, Sohn JH, Chapiro J, Zhao Y, Gorodetski B, Fleckenstein F, Smolka S, Radaelli A, van der Bom IM, Lin M, Geschwind JF. Cardiovasc Intervent Radiol. 2016 Oct; 2016 Jul 5. PMID: 27380872.
Renal Cell Carcinoma Metastatic to the Liver: Early Response Assessment after Intraarterial Therapy Using 3D Quantitative Tumor Enhancement Analysis.Fleckenstein FN, Schernthaner RE, Duran R, Sohn JH, Sahu S, Marshall K, Lin M, Gebauer B, Chapiro J, Salem R, Geschwind JF. Transl Oncol. 2016 Oct; 2016 Sep 12. PMID: 27641641.
3D Quantitative tumour burden analysis in patients with hepatocellular carcinoma before TACE: comparing single-lesion vs. multi-lesion imaging biomarkers as predictors of patient survival.Fleckenstein FN, Schernthaner RE, Duran R, Sohn JH, Sahu S, Zhao Y, Hamm B, Gebauer B, Lin M, Geschwind JF, Chapiro J. Eur Radiol. 2016 Sep; 2016 Jan 13. PMID: 26762942.
Sorafenib in combination with transarterial chemoembolization for the treatment of hepatocellular carcinoma.Geschwind JF, Chapiro J. Clin Adv Hematol Oncol. 2016 Aug. PMID: 27487101.
Sorafenib in Combination With Transarterial Chemoembolization for the Treatment of Hepatocellular Carcinoma.Geschwind JH, Chapiro J. Gastroenterol Hepatol (N Y). 2016 Aug. PMID: 27917085.
Science to Practice: Systemic Implications of Ablative Tumor Therapies-Reality Uncovered and Myths Exposed?Chapiro J, Geschwind JF. Radiology. 2016 Aug. PMID: 27429140.
Multimodality Imaging of Ethiodized Oil-loaded Radiopaque Microspheres during Transarterial Embolization of Rabbits with VX2 Liver Tumors.Tacher V, Duran R, Lin M, Sohn JH, Sharma KV, Wang Z, Chapiro J, Gacchina Johnson C, Bhagat N, Dreher MR, Schäfer D, Woods DL, Lewis AL, Tang Y, Grass M, Wood BJ, Geschwind JF. Radiology. 2016 Jun; 2015 Dec 16. PMID: 26678453.
Radiologic-pathologic analysis of quantitative 3D tumour enhancement on contrast-enhanced MR imaging: a study of ROI placement.Chockalingam A, Duran R, Sohn JH, Schernthaner R, Chapiro J, Lee H, Sahu S, Nguyen S, Geschwind JF, Lin M. Eur Radiol. 2016 Jan; 2015 May 21. PMID: 25994198.
Targeting glucose metabolism in cancer: new class of agents for loco-regional and systemic therapy of liver cancer and beyond?Savic LJ, Chapiro J, Duwe G, Geschwind JF. Hepat Oncol. 2016 Jan 1. PMID: 26989470.
Automatic bone removal for 3D TACE planning with C-arm CBCT: Evaluation of technical feasibility.Wang Z, Hansis E, Chen R, Duran R, Chapiro J, Sheu YR, Kobeiter H, Grass M, Geschwind JF, Lin M. Minim Invasive Ther Allied Technol. 2016; 2016 Feb 29. PMID: 26923140.