FapR regulates HssRS-mediated heme homeostasis in Bacillus anthracis
Pi H, Burroughs O, Carlin S, Beavers W, Hillebrand G, Krystofiak E, Stauff D, Skaar E. FapR regulates HssRS-mediated heme homeostasis in Bacillus anthracis. MBio 2025, 16: e02057-24. PMID: 40407322, PMCID: PMC12153329, DOI: 10.1128/mbio.02057-24.Peer-Reviewed Original Research
ConceptsHeme homeostasisKnowledge of bacterial physiologyTwo-component signaling systemRegulation of fatty acid biosynthesisMembrane integrityFatty acid biosynthesisHeme toxicityCausative agent of anthraxHeme stressGram-positive pathogensAgent of anthraxGram-positive bacteriaBacterial physiologyHeme sensingTranscriptional regulationAcid biosynthesisTranscription factorsFapRFacultative anaerobesHeme biosynthesisRegulatory pathwaysHssRSVertebrate bloodMolecular adaptationsMolecular mechanisms