Pi Laboratory

Clostridioides difficile is a Gram-positive, spore-forming anaerobic bacterium and the leading cause of nosocomial and antibiotic-associated intestinal infections in the United States. The Pi lab employs a multidisciplinary approach that integrates genetic, biochemical, structural biology, and imaging techniques as well as animal infection models to study this gut microbe. Our primary research emphasis lies in exploring the microbial stress defense mechanisms critical for C. difficile colonization and survival during infection.