Cerebral Hemodynamics after Large-vessel Occlusion Ischemic Stroke: Studying the Pathophysiology and Identifying Novel Targets for Intervention

Endovascular thrombectomy (EVT) is a highly effective therapy for patients with large-vessel occlusion (LVO) ischemic stroke. Patient selection is based on a mismatch between the area of the irreversibly infarcted stroke core and the ischemic tissue that is hypoperfused but still viable. Preserving ischemic tissue and preventing further infarct progression will increase the number of patients eligible for EVT and improve outcomes. Through analysis, individual patient physiology, and large clinical datasets, we aim to discern the role of hemodynamics in infarct progression and to uncover new targets for intervention.