2009
Conserved Telomere Maintenance Component 1 Interacts with STN1 and Maintains Chromosome Ends in Higher Eukaryotes
Surovtseva Y, Churikov D, Boltz K, Song X, Lamb J, Warrington R, Leehy K, Heacock M, Price C, Shippen D. Conserved Telomere Maintenance Component 1 Interacts with STN1 and Maintains Chromosome Ends in Higher Eukaryotes. Molecular Cell 2009, 36: 207-218. PMID: 19854131, PMCID: PMC2768651, DOI: 10.1016/j.molcel.2009.09.017.Peer-Reviewed Original ResearchMeSH KeywordsAnaphaseArabidopsisArabidopsis ProteinsCell Line, TumorChromosomal Proteins, Non-HistoneChromosomes, PlantConserved SequenceEukaryotic CellsGenomic InstabilityHumansIn Situ Hybridization, FluorescenceMutationNucleic Acid ConformationProtein BindingRecombination, GeneticTelomereTelomere-Binding ProteinsConceptsG-overhangsOB-fold domainDNA damage responseArabidopsis mutantsMulticellular organismsHigher eukaryotesTEN1 (CST) complexChromosome endsHuman CTC1Telomere integrityTelomere maintenanceDiverse speciesDamage responseEnd fusionsChromatin bridgesTelomere lossRNAi triggersDevelopmental defectsCTC1Stn1PlantsEukaryotesOrthologsVertebratesMutants
2008
STN1 protects chromosome ends in Arabidopsis thaliana
Song X, Leehy K, Warrington R, Lamb J, Surovtseva Y, Shippen D. STN1 protects chromosome ends in Arabidopsis thaliana. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 19815-19820. PMID: 19064932, PMCID: PMC2604966, DOI: 10.1073/pnas.0807867105.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceArabidopsisArabidopsis ProteinsChromosomal Proteins, Non-HistoneChromosomes, PlantMolecular Sequence DataMutationTelomereConceptsChromosome end protectionEnd chromosome fusionsOligonucleotide/oligosaccharideSignificant sequence similarityDNA repair machineryDouble-strand breaksDistinct subcomplexesMulticellular eukaryotesTelomere capChromosome fusionsArabidopsis thalianaTelomere proteinsChromosome endsSubtelomeric DNASchizosaccharomyces pombeShelterin componentsTelomere integrityVertebrate telomeresRepair machinerySequence similarityNucleolytic attackTelomere recombinationEnd protectionDevelopmental defectsStn1
2005
The Arabidopsis Pot1 and Pot2 Proteins Function in Telomere Length Homeostasis and Chromosome End Protection
Shakirov E, Surovtseva Y, Osbun N, Shippen D. The Arabidopsis Pot1 and Pot2 Proteins Function in Telomere Length Homeostasis and Chromosome End Protection. Molecular And Cellular Biology 2005, 25: 7725-7733. PMID: 16107718, PMCID: PMC1190295, DOI: 10.1128/mcb.25.17.7725-7733.2005.Peer-Reviewed Original ResearchConceptsChromosome end protectionTelomere length homeostasisEnd protectionLength homeostasisGenome instabilityWild typePot1-like proteinsSevere growth defectOligonucleotide/oligosaccharideMassive genome instabilityBulk telomeresTransgenic plantsGrowth defectProtein functionPositive regulationN-terminusBinding proteinAnalogous regionMutantsArabidopsisPlantsLength controlCorresponding regionPOT1Protein