2021
Probing Microbiome Genotoxicity: A Stable Colibactin Provides Insight into Structure–Activity Relationships and Facilitates Mechanism of Action Studies
Wernke KM, Tirla A, Xue M, Surovtseva YV, Menges FS, Herzon SB. Probing Microbiome Genotoxicity: A Stable Colibactin Provides Insight into Structure–Activity Relationships and Facilitates Mechanism of Action Studies. Journal Of The American Chemical Society 2021, 143: 15824-15833. PMID: 34524796, DOI: 10.1021/jacs.1c07559.Peer-Reviewed Original ResearchConceptsFanconi anemia DNA repair pathwayBiosynthetic gene clusterDNA repair pathwaysGene clusterRepair pathwaysDNA bindingBacterial phenotypesInduces DNAGenotoxic effectsHuman microbiomeColibactinBiosynthetic precursorNatural product structuresBiological studiesPathwayStructure-activity relationshipsAction studiesGenotoxic metabolitesOrganismsOncogenesisDNATumorigenesisMicrobiomeFacilitate mechanismsPhenotype
2009
Conserved Telomere Maintenance Component 1 Interacts with STN1 and Maintains Chromosome Ends in Higher Eukaryotes
Surovtseva Y, Churikov D, Boltz K, Song X, Lamb J, Warrington R, Leehy K, Heacock M, Price C, Shippen D. Conserved Telomere Maintenance Component 1 Interacts with STN1 and Maintains Chromosome Ends in Higher Eukaryotes. Molecular Cell 2009, 36: 207-218. PMID: 19854131, PMCID: PMC2768651, DOI: 10.1016/j.molcel.2009.09.017.Peer-Reviewed Original ResearchMeSH KeywordsAnaphaseArabidopsisArabidopsis ProteinsCell Line, TumorChromosomal Proteins, Non-HistoneChromosomes, PlantConserved SequenceEukaryotic CellsGenomic InstabilityHumansIn Situ Hybridization, FluorescenceMutationNucleic Acid ConformationProtein BindingRecombination, GeneticTelomereTelomere-Binding ProteinsConceptsG-overhangsOB-fold domainDNA damage responseArabidopsis mutantsMulticellular organismsHigher eukaryotesTEN1 (CST) complexChromosome endsHuman CTC1Telomere integrityTelomere maintenanceDiverse speciesDamage responseEnd fusionsChromatin bridgesTelomere lossRNAi triggersDevelopmental defectsCTC1Stn1PlantsEukaryotesOrthologsVertebratesMutants
2004
A C-terminal Myb Extension Domain Defines a Novel Family of Double-strand Telomeric DNA-binding Proteins in Arabidopsis *
Karamysheva Z, Surovtseva Y, Vespa L, Shakirov E, Shippen D. A C-terminal Myb Extension Domain Defines a Novel Family of Double-strand Telomeric DNA-binding Proteins in Arabidopsis *. Journal Of Biological Chemistry 2004, 279: 47799-47807. PMID: 15364931, DOI: 10.1074/jbc.m407938200.Peer-Reviewed Original ResearchConceptsPlant telomeric DNATelomeric DNA bindingDNA bindingTelomeric DNASingle Myb-like domainTelomeric DNA-binding proteinMyb-like domainDistinct gene familiesGenome data baseDNA-binding proteinsSearch of genesRegion C-terminalFamily 2Isolated C-terminal fragmentFamily 1Plant telomeresMyb domainArabidopsis genesGene familyC-terminal fragmentImmunoprecipitation experimentsC-terminusRecombinant proteinsC-terminalProtein composition