Nicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response
Zakiniaeiz Y, Liu H, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Matuskey D, Chen MK, Cosgrove KP, Morris ED. Nicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response. Nicotine & Tobacco Research 2022, 24: 1597-1606. PMID: 35100429, PMCID: PMC9575980, DOI: 10.1093/ntr/ntac026.Peer-Reviewed Original ResearchConceptsNicotine replacement therapyDopamine releasePlacebo patchDorsal striatumTobacco smokingReplacement therapyFirst-line pharmacological treatmentVentral striatumMajor public health burdenPositron emission tomography scanEmission tomography scanPublic health burdenNicotine dependence levelNicotine metabolism rateNicotinic acetylcholine receptorsCounter-balanced orderTobacco smokersCigarette smokingSmoking cessationDopamine terminalsPharmacological treatmentDependent smokersFast metabolizersSlow metabolizersNicotine actsMechanisms and Clinical Features of Co-Occurring Opioid and Nicotine Use
Lichenstein SD, Zakiniaeiz Y, Yip SW, Garrison KA. Mechanisms and Clinical Features of Co-Occurring Opioid and Nicotine Use. Current Addiction Reports 2019, 6: 114-125. PMID: 32864292, PMCID: PMC7451029, DOI: 10.1007/s40429-019-00245-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNicotine useClinical featuresCholinergic systemUse disordersOpioid use disorderPurpose of ReviewToSubstance use disordersSex/gender considerationsRecent FindingsOpioidPathophysiological mechanismsSmoking cessationRisk factorsTreatment outcomesDrug rewardOpioidsFurther studiesHigh rateTreatmentDisordersHighlight areasPainReviewToEtiologyPharmacologicalCessation