2017
Hippocampal α7 nicotinic ACh receptors contribute to modulation of depression‐like behaviour in C57BL/6J mice
Mineur YS, Mose TN, Blakeman S, Picciotto MR. Hippocampal α7 nicotinic ACh receptors contribute to modulation of depression‐like behaviour in C57BL/6J mice. British Journal Of Pharmacology 2017, 175: 1903-1914. PMID: 28264149, PMCID: PMC5979617, DOI: 10.1111/bph.13769.Peer-Reviewed Original ResearchMeSH KeywordsAlpha7 Nicotinic Acetylcholine ReceptorAnimalsBehavior, AnimalDepressionFemaleHippocampusMaleMiceMice, Inbred C57BLPhysostigmineConceptsDepression-like behaviorNicotinic ACh receptorsFemale miceMale miceCholinergic signalingACh receptorsΑ7 nAChRsSignificant antidepressant-like effectΑ7 nicotinic ACh receptorsEffect of α7Antidepressant-like effectsAgonist GTS-21Depression-related behaviorsC-Fos immunoreactivityACh receptor antagonistDepression-like phenotypeAnxiety-like behaviorNicotinic acetylcholine receptorsAnxiety-like phenotypeHippocampal α7Physostigmine administrationAntagonist methyllycaconitineReceptor antagonistSwim testGTS-21
2016
Comparative mRNA analysis of behavioral and genetic mouse models of aggression
Malki K, Tosto MG, Pain O, Sluyter F, Mineur YS, Crusio WE, de Boer S, Sandnabba KN, Kesserwani J, Robinson E, Schalkwyk LC, Asherson P. Comparative mRNA analysis of behavioral and genetic mouse models of aggression. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2016, 171: 427-436. PMID: 26888158, DOI: 10.1002/ajmg.b.32424.Peer-Reviewed Original ResearchConceptsProbe setsExpression of genesGenetic mouse studiesGene hubsGene networksProtein degradationCandidate genesERG2 geneNetwork analysisGenetic mouse modelsDiscovery-replication designRedox pathwaysGenesP38 MAPKAggression-related traitsMouse modelMouse brain tissueGenetic modelsMRNA studiesMRNA analysisDiscovery studiesDiscovery setPathwayMouse studiesSignificant overlap
2015
Modulation of aggressive behavior in mice by nicotinic receptor subtypes
Lewis AS, Mineur YS, Smith PH, Cahuzac EL, Picciotto MR. Modulation of aggressive behavior in mice by nicotinic receptor subtypes. Biochemical Pharmacology 2015, 97: 488-497. PMID: 26212554, PMCID: PMC4600457, DOI: 10.1016/j.bcp.2015.07.019.Peer-Reviewed Original ResearchConceptsAcute nicotine administrationNicotine administrationHypolocomotor effectNicotinic acetylcholine receptor agonist nicotineAgonist GTS-21Nicotinic receptor subtypesAnti-aggressive propertiesDihydro-β-erythroidineBALB/cNeurobiology of aggressionSocial interaction timeCurrent pharmacotherapyAntagonist methyllycaconitineC57BL/6 miceWorse outcomesGTS-21Receptor subtypesPathological aggressionAgonist nicotineΑ7 nAChRsSpecific treatmentSide effectsPharmacological studiesNeuropsychiatric conditionsNicotine
2012
Gabra5-gene haplotype block associated with behavioral properties of the full agonist benzodiazepine chlordiazepoxide
Clément Y, Prut L, Saurini F, Mineur Y, Le Guisquet A, Védrine S, Andres C, Vodjdani G, Belzung C. Gabra5-gene haplotype block associated with behavioral properties of the full agonist benzodiazepine chlordiazepoxide. Behavioural Brain Research 2012, 233: 474-482. PMID: 22677273, DOI: 10.1016/j.bbr.2012.05.041.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAnimalsBehavior, AnimalBenzodiazepinesCarrier ProteinsCerebral CortexChlordiazepoxideDose-Response Relationship, DrugGene Expression RegulationHaplotypesHippocampusMaleMaze LearningMembrane ProteinsMiceMice, Inbred C57BLMice, Mutant StrainsMotor ActivityMutationReaction TimeReceptors, GABA-ARNA, MessengerRotarod Performance TestSpace Perception
2001
Neuroanatomy of cerebellum and olfactory bulb in a substrain of C57BL/6J inbred mice carrying a spontaneous mutation
Pager J, Mineur Y, Pinoteau W, LeRoy I, Crusio W. Neuroanatomy of cerebellum and olfactory bulb in a substrain of C57BL/6J inbred mice carrying a spontaneous mutation. Physiology & Behavior 2001, 73: 827-831. PMID: 11566215, DOI: 10.1016/s0031-9384(01)00519-4.Peer-Reviewed Original Research