Featured Publications
Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis
Wang P, Yang X, Zhang L, Sha S, Huang J, Peng J, Gu J, Pearson J, Hu Y, Zhao H, Wong F, Wang Q, Wen L. Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis. Nature Communications 2024, 15: 4232. PMID: 38762479, PMCID: PMC11102548, DOI: 10.1038/s41467-024-48611-8.Peer-Reviewed Original ResearchConceptsToll-like receptor 9Gut microbiotaGut microbial communityTransferred to germ-free miceB cellsGerm-free miceTLR9 deficiencyKO miceGene sequencesGerminal center B cellsMicrobial communitiesMarginal zone B cellsGut dysbiosisFollicular helper cellsSelf-DNAMetabolic homeostasisAssociated with increased frequencyPro-inflammatory stateFat tissue inflammationGutHigh-fat dietMicrobiotaHelper cellsT cellsControl mice
2022
Gut Microbiota and Immune Modulatory Properties of Human Breast Milk Streptococcus salivarius and S. parasanguinis Strains
Li S, Li N, Wang C, Zhao Y, Cao J, Li X, Zhang Z, Li Y, Yang X, Wang X, Che C, Zhao Y, Wang L, Zhao L, Shen J. Gut Microbiota and Immune Modulatory Properties of Human Breast Milk Streptococcus salivarius and S. parasanguinis Strains. Frontiers In Nutrition 2022, 9: 798403. PMID: 35273986, PMCID: PMC8901577, DOI: 10.3389/fnut.2022.798403.Peer-Reviewed Original ResearchImmune-modulatory propertiesHuman breast milkGut microbiotaBreast milkModulatory propertiesAnti-inflammatory Treg cellsHuman peripheral blood mononuclear cellsPeripheral blood mononuclear cellsIleal mRNA expressionBlood mononuclear cellsT helper cellsAnti-inflammatory potentialPostnatal week 3Postnatal day 1Microbiota α-diversityImmune response genesTreg cellsBreast feedingHelper cellsMononuclear cellsIleal expressionSuckling miceGut immunityWeaning miceInfant gut