2023
Combination Therapy of Low-dose Steroids, Tacrolimus and Mycophenolate Mofetil in Primary Membranous Nephropathy: A Single-center Retrospective Cohort Study
Zhao S, Jia L, Cui C, Chen Z, Duan Z, Gao J, Wei L, Xue X, Lei F, Yang Y, Liu J, Xu P, Wang R, Wei Y, Tian X, Fu R. Combination Therapy of Low-dose Steroids, Tacrolimus and Mycophenolate Mofetil in Primary Membranous Nephropathy: A Single-center Retrospective Cohort Study. Integrative Medicine In Nephrology And Andrology 2023, 10: e00012. DOI: 10.1097/imna-d-22-00012.Peer-Reviewed Original ResearchPrimary membranous nephropathyIntravenous cyclophosphamideRegimen groupMycophenolate mofetilMembranous nephropathyNephrotic syndromeCombination therapyBiopsy-proven primary membranous nephropathySingle-center retrospective cohort studyPC groupCumulative complete remission ratesLow-dose glucocorticoidsLow-dose steroidsNon-inferior efficacyRetrospective cohort studySerum creatinine levelsComplete remission rateCommon pathological typeUrinary protein levelsFavorable safety profileBest combination therapyAlternative treatment choiceRemission rateAdverse eventsCohort study
2022
Effect of pulsed intravenous methylprednisolone with alternative low-dose prednisone on high-risk IgA nephropathy: a 18-month prospective clinical trial
Li Y, Fu R, Gao J, Wang L, Duan Z, Tian L, Ge H, Ma X, Zhang Y, Li K, Xu P, Tian X, Chen Z. Effect of pulsed intravenous methylprednisolone with alternative low-dose prednisone on high-risk IgA nephropathy: a 18-month prospective clinical trial. Scientific Reports 2022, 12: 255. PMID: 34996948, PMCID: PMC8742122, DOI: 10.1038/s41598-021-03691-0.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAdministration, OralAdultDisease ProgressionDrug TaperingDrug Therapy, CombinationFemaleGlomerulonephritis, IGAGlucocorticoidsHumansKidney Failure, ChronicMaleMethylprednisolonePrednisoneProspective StudiesProteinuriaPulse Therapy, DrugRemission InductionRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsLow-dose prednisoneComplete remissionFP groupIntravenous methylprednisoloneHigh-risk IgA nephropathyOxford MEST-C scoreChinese Clinical Trial RegistryPulsed intravenous methylprednisoloneACEI/ARBClinical Trials RegistryProspective clinical trialsMEST-C scoreFavorable safety profilePercentage of CROral prednisoneTotal remissionAdult patientsNephropathy patientsPrednisone regimenCushing's syndromeMore patientsPrimary outcomeTrials RegistryClinical outcomesIgA nephropathy