2022
New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors
Cui C, Tian X, Wei L, Wang Y, Wang K, Fu R. New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors. Frontiers In Pharmacology 2022, 13: 1002871. PMID: 36172198, PMCID: PMC9510841, DOI: 10.3389/fphar.2022.1002871.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsDipeptidyl peptidase 8Peptidase 8Dipeptidyl peptidase 9Serine proteolytic enzymesBiological processesNew potential targetsPhysiological functionsSpecific substratesCell behaviorNormal developmentEnergy metabolismEssential roleChronic kidney diseaseN-terminal dipeptidePenultimate positionPotential targetOrgan fibrosisPathological rolePathological processesNew insightsTreatment of tumorsProteolytic enzymesRecent research advancesKidney diseaseCell pyroptosis
2020
Murine Epsins Play an Integral Role in Podocyte Function
Wang Y, Pedigo CE, Inoue K, Tian X, Cross E, Ebenezer K, Li W, Wang Z, Shin JW, Schwartze E, Groener M, Ishibe S. Murine Epsins Play an Integral Role in Podocyte Function. Journal Of The American Society Of Nephrology 2020, 31: 2870-2886. PMID: 33051360, PMCID: PMC7790213, DOI: 10.1681/asn.2020050691.Peer-Reviewed Original ResearchConceptsSerum response factorPodocyte-specific lossCell division control protein 42 homologCell adhesionRegulation of Cdc42Integrin expressionProtein Cdc42Membrane proteinsTriple knockout miceEpsinDownstream regulationFoot process effacementPodocyte functionResponse factorPrimary podocytesCdc42Essential roleIndispensable roleProcess effacementExpressionRegulationKnockout miceIntegral rolePodocytesHomolog