2000
Parathyroid hormone-related protein induces spontaneous osteoclast formation via a paracrine cascade
Nakchbandi I, Weir E, Insogna K, Philbrick W, Broadus A. Parathyroid hormone-related protein induces spontaneous osteoclast formation via a paracrine cascade. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 7296-7300. PMID: 10829073, PMCID: PMC16539, DOI: 10.1073/pnas.110553397.Peer-Reviewed Original ResearchConceptsNumber of osteoclastsEffects of PTHrPOsteoclast formationDF cellsBone resorptionFactor expressionOsteoclastic bone resorptionDental follicle cellsHormone-related proteinOsteoclast differentiation factorStellate reticulum cellsOsteoclastogenesis inhibitory factorCoronal tooth surfacesSpontaneous osteoclast formationParacrine cascadeParathyroid hormoneEruption pathwayReticulum cellsPeripheral skeletonTooth eruptionOsteoclast precursorsPTH/PTHrP.Inhibitory factorFunctional osteoclastsCrypt cells
1998
PTHrP Regulates Epidermal Differentiation in Adult Mice
Foley J, Wysolmerski J, Dreyer B, Broadus A, Philbrick W, Longely B. PTHrP Regulates Epidermal Differentiation in Adult Mice. Journal Of Investigative Dermatology 1998, 111: 1122-1128. PMID: 9856827, DOI: 10.1046/j.1523-1747.1998.00428.x.Peer-Reviewed Original ResearchConceptsPTHrP-knockout miceKeratin 14 promoterAdult miceSebaceous glandsHuman keratin 14 promoterParathyroid hormone-related peptideHyperplastic sebaceous glandsHormone-related peptideAbsence of PTHrPNumber of organsWk of agePremature acquisitionEpidermal proliferation rateMarked acanthosisTransgenic replacementReciprocal findingsTransgenic micePTHrPPTHrP geneMiceMammary glandBasal keratinocytesDisplay abnormalitiesLethal chondrodystrophyFibrotic dermisParathyroid hormone-related protein is required for tooth eruption
Philbrick W, Dreyer B, Nakchbandi I, Karaplis A. Parathyroid hormone-related protein is required for tooth eruption. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 11846-11851. PMID: 9751753, PMCID: PMC21728, DOI: 10.1073/pnas.95.20.11846.Peer-Reviewed Original ResearchConceptsPTHrP-knockout miceTooth eruptionEruption pathwayPTHrP expressionType I PTH/PTHrP receptorEnamel epitheliumPTH/PTHrP receptorOverexpression of PTHrPHormone-related proteinMonths of ageNormal tooth developmentParathyroid hormoneBone resorptionPTHrP receptorPTHrP mRNAKnockout miceTransgenic miceAlveolar boneDental mesenchymeLevel of expressionMiceBone formationSkeletal abnormalitiesTooth developmentKeratin 14Parathyroid hormone‐related protein is a developmental regulatory molecule
Philbrick W. Parathyroid hormone‐related protein is a developmental regulatory molecule. European Journal Of Oral Sciences 1998, 106: 32-37. PMID: 9541200, DOI: 10.1111/j.1600-0722.1998.tb02150.x.Peer-Reviewed Original ResearchConceptsDevelopmental regulatory moleculeOverexpression of PTHrPHormone-related proteinHormone-related peptideSingle G protein-coupled receptorG protein-coupled receptorsProtein-coupled receptorsPTHrP overexpressionHumoral hypercalcemiaTumor productsPTHrP functionsKnockout miceMammary epithelial cellsTransgenic miceRegulatory moleculesMiceEpithelial cellsPTH geneRegulatory effectsPTHrPN-terminal productType IMultiple tissuesConvincing evidenceOverexpression
1997
Bcl-2 Lies Downstream of Parathyroid Hormone–related Peptide in a Signaling Pathway That Regulates Chondrocyte Maturation during Skeletal Development
Amling M, Neff L, Tanaka S, Inoue D, Kuida K, Weir E, Philbrick W, Broadus A, Baron R. Bcl-2 Lies Downstream of Parathyroid Hormone–related Peptide in a Signaling Pathway That Regulates Chondrocyte Maturation during Skeletal Development. Journal Of Cell Biology 1997, 136: 205-213. PMID: 9008714, PMCID: PMC2132464, DOI: 10.1083/jcb.136.1.205.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBcl-2-Associated X ProteinBone DevelopmentCartilageCells, CulturedCollagenGene ExpressionGrowth PlateHumansHypertrophyMiceMice, KnockoutMice, TransgenicOrgan SpecificityParathyroid Hormone-Related ProteinPromoter Regions, GeneticProteinsProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2Recombinant Fusion ProteinsSignal TransductionConceptsSkeletal developmentChondrocyte maturationBcl-2Cell deathCollagen II promoterApoptotic cell deathMutant PTH/PTHrP receptorsDevelopmental programMolecular mechanismsSignaling pathwaysCell typesGrowth plate chondrocytesTargeted disruptionGenesMetaphyseal chondrodysplasiaMaturationPTHrP geneTransgenic micePathwayPTH/PTHrP receptorAccelerated maturationSkeletal dysplasiaHormone-related peptideMajor roleChondrocytes