2024
Disparities in Receipt of Medications for Opioid Use Disorder Before and During the COVID-19 Pandemic in the US Veterans Health Administration.
Sung M, León C, Reisman J, Gordon K, Kerns R, Li W, Liu W, Mitra A, Yu H, Becker W. Disparities in Receipt of Medications for Opioid Use Disorder Before and During the COVID-19 Pandemic in the US Veterans Health Administration. Substance Use & Addiction Journal 2024, 29767342241293334. PMID: 39569566, DOI: 10.1177/29767342241293334.Peer-Reviewed Original ResearchMOUD receiptElixhauser Comorbidity IndexOpioid use disorderSocial determinants of healthVeterans Health Administration electronic health record dataElectronic health record dataUS Veterans Health AdministrationDeterminants of healthVeterans Health AdministrationHealth record dataProportion of veteransReceipt of medicationsSubstance useComorbidity indexTargeted outreach effortsUse disorderCOVID-19 pandemicProportion of patientsSocial determinantsReceipt of MOUDHealth AdministrationRecord dataEffect sizeMOUD engagementCalculated proportionsGuideline concordant opioid therapy in Veterans receiving VA and community care
Ma P, Cheng Y, Goulet J, Sandbrink F, Brandt C, Spevak C, Kean J, Becker W, Libin A, Shara N, Sheriff H, Houston J, Butler J, Workman E, Agrawal R, Kupersmith J, Zeng-Treitler Q. Guideline concordant opioid therapy in Veterans receiving VA and community care. BMC Health Services Research 2024, 24: 1284. PMID: 39456008, PMCID: PMC11515256, DOI: 10.1186/s12913-024-11742-1.Peer-Reviewed Original ResearchConceptsDual-system usersGuideline concordant careConcordant careVA servicesCommunity careElectronic health record dataHealth record dataRates of guideline concordanceVA Medical CenterOpioid therapyAdherence to specific guidelinesBaltimore VA Medical CenterGuideline adherenceGuideline concordanceAdherence ratesGuideline recommendationsRecord dataCareDemographic factorsMedical CenterVeteransComorbid conditionsOpioid crisisUrine drug screensSpecific guidelinesLong-Term Use of Muscle Relaxant Medications for Chronic Pain
Oldfield B, Gleeson B, Morford K, Adams Z, Funaro M, Becker W, Merlin J. Long-Term Use of Muscle Relaxant Medications for Chronic Pain. JAMA Network Open 2024, 7: e2434835. PMID: 39298168, PMCID: PMC11413720, DOI: 10.1001/jamanetworkopen.2024.34835.Peer-Reviewed Original ResearchConceptsLow back painBack painSkeletal muscle relaxantsChronic painRandomized clinical trialsNeck painCohort studyEfficacy of long-term useLong-term useSystematically searched Ovid MEDLINEMuscle relaxant medicationsModerate risk of biasOpioid prescribing guidelinesRisk of biasQuality of cohort studiesWeb of SciencePainful crampsRelaxant medicationsChronic pain syndromesPainful spasmsOvid MEDLINEPrescribing guidelinesSystematic reviewIncreased prescriptionModerate riskFactors associated with participation in a walking intervention for veterans who smoke and have chronic pain
Muller R, Driscoll M, DeRycke E, Edmond S, Becker W, Bastian L. Factors associated with participation in a walking intervention for veterans who smoke and have chronic pain. Journal Of Behavioral Medicine 2024, 47: 994-1001. PMID: 39143444, DOI: 10.1007/s10865-024-00511-4.Peer-Reviewed Original ResearchFactors associated with participationCognitive behavioral interventionPain locationCounseling sessionsAverage daily step countPain self-management interventionMedian daily stepsDaily step countIntegrated smoking cessationSelf-management interventionsTelephone counseling sessionsChronic painModerate pain intensityMedian pack-yearsMultivariate logistic regressionWalking interventionLE painDaily stepsStep countsPain interferenceWalk componentSmoking cessationPain intensityPack-yearsIncreased oddsImplementation, intervention, and downstream costs for implementation of a multidisciplinary complex pain clinic in the Veterans Health Administration
Daniels S, Cave S, Wagner T, Perez T, Edmond S, Becker W, Midboe A. Implementation, intervention, and downstream costs for implementation of a multidisciplinary complex pain clinic in the Veterans Health Administration. Health Services Research 2024, 59: e14345. PMID: 38956400, PMCID: PMC11540574, DOI: 10.1111/1475-6773.14345.Peer-Reviewed Original ResearchVeterans Health AdministrationIntervention sitesIntervention costsHealth AdministrationPain clinicDownstream costsQuasi-experimental study designChronic painVA administrative dataAverage intervention costComplex chronic painRoutes of careActivity-based cost dataHealthcare utilization costsVA Medical CenterHistory of chronic painMicro-costing methodImplementation facilitatorsHospice patientsCost of treating patientsControl groupAdministrative dataInpatient costsIntervention cohortClinically similar characteristicsT50 Receipt of Prescribed Opioids and Benzodiazepines After Non-Fatal Overdose and Risk of Subsequent Overdose
Howell B, Black A, Lin H, Lauretta G, Heimer R, Hawk K, D'Onofrio G, Fiellin D, Becker W. T50 Receipt of Prescribed Opioids and Benzodiazepines After Non-Fatal Overdose and Risk of Subsequent Overdose. Drug And Alcohol Dependence 2024, 260: 110499. DOI: 10.1016/j.drugalcdep.2023.110499.Peer-Reviewed Original ResearchODD: A Benchmark Dataset for the Natural Language Processing Based Opioid Related Aberrant Behavior Detection.
Kwon S, Wang X, Liu W, Druhl E, Sung M, Reisman J, Li W, Kerns R, Becker W, Yu H. ODD: A Benchmark Dataset for the Natural Language Processing Based Opioid Related Aberrant Behavior Detection. Annual Meeting 2024, 2024: 4338-4359. PMID: 39224833, PMCID: PMC11368170.Peer-Reviewed Original ResearchBenchmark datasetsState-of-the-art natural language processing modelsNatural language processing modelsState-of-the-artLanguage processing modelsAberrant behaviorDetection datasetMacro-average areaBehavior detectionPrecision recall curveDiagnosed opioid dependencePerformance improvementRecall curveDatasetProcess modelExperimental resultsCentral nervous system-relatedOpioid dependenceNervous system-relatedMedication changesOpioidBenchmarksFocus on Function: Aligning Patient Values with Clinician Reassessment of Long-Term Opioid Therapy
Edmond S, Becker W. Focus on Function: Aligning Patient Values with Clinician Reassessment of Long-Term Opioid Therapy. Journal Of General Internal Medicine 2024, 39: 2108-2109. PMID: 38806796, PMCID: PMC11306475, DOI: 10.1007/s11606-024-08821-8.Peer-Reviewed Original ResearchPrescription Opioid Dose Change Before Fatal Opioid-Detected Overdose.
Kazemitabar M, Howell B, Becker W, Lin H, Grau L, Heimer R, D'Onofrio G, Hawk K, Fiellin D, Black A. Prescription Opioid Dose Change Before Fatal Opioid-Detected Overdose. Journal Of Studies On Alcohol And Drugs 2024, 85: 815-819. PMID: 38775307, DOI: 10.15288/jsad.24-00026.Peer-Reviewed Original ResearchPrescribed opioidsOpioid dose changesRapid dose increaseNon-HispanicOverdose deathsToxicological resultsNon-prescription opioidsBlack non-HispanicMorphine equivalentsOpioid therapyWhite non-HispanicDose changesDaily doseMean ageDispensed opioidsPrescription opioidsPrescribing patternsOpioidDose increaseOpioid overdose crisisIncreasing dosesStudy investigated patternsEffect of timeEffects of ageSecondary analysisIdentifying provider, patient and practice factors that shape long-term opioid prescribing for cancer pain: a qualitative study of American and Australian providers
Fereydooni S, Lorenz K, Azarfar A, Luckett T, Phillips J, Becker W, Giannitrapani K. Identifying provider, patient and practice factors that shape long-term opioid prescribing for cancer pain: a qualitative study of American and Australian providers. BMJ Open 2024, 14: e082033. PMID: 38514141, PMCID: PMC10961503, DOI: 10.1136/bmjopen-2023-082033.Peer-Reviewed Original ResearchConceptsPractice-related factorsLong-term opioid prescribingPrescribed long-term opioid therapyQualitative studyOpioid prescribingQuality of careProvider-related factorsLong-term prescribingPatient’s social contextLong-term opioid therapyAlternative pain therapiesCancer-related painConcurrent qualitative studyDisadvantaged patientsHealthcare interventionsExacerbate disparitiesIdentified providersAustralian providersOpioid practicesSocioeconomic statusSecondary analysisPrescribed opioidsCancer painProvidersPrescribingEfficacy of Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT) in Individuals With Chronic Pain and Opioid Use Disorder: Protocol for a Randomized Clinical Trial of a Digital Cognitive Behavioral Treatment
MacLean R, Ankawi B, Driscoll M, Gordon M, Frankforter T, Nich C, Szollosy S, Loya J, Brito L, Ribeiro M, Edmond S, Becker W, Martino S, Sofuoglu M, Heapy A. Efficacy of Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT) in Individuals With Chronic Pain and Opioid Use Disorder: Protocol for a Randomized Clinical Trial of a Digital Cognitive Behavioral Treatment. JMIR Research Protocols 2024, 13: e54342. PMID: 38506917, PMCID: PMC10993119, DOI: 10.2196/54342.Peer-Reviewed Original ResearchPain Care at Home to Amplify Function: Protocol Article.
Black A, Edmond S, Frank J, Abelleira A, Snow J, Wesolowicz D, Becker W. Pain Care at Home to Amplify Function: Protocol Article. Substance Use & Addiction Journal 2024, 29767342241236032. PMID: 38469833, DOI: 10.1177/29767342241236032.Peer-Reviewed Original ResearchPrimary care providersVeterans Health AdministrationPromote self-management strategiesImplementation facilitation strategyEffectiveness-implementation trialChronic painSelf-management strategiesGuideline-concordant practicesMedication management supportOpioid medication safetyIntervention cost-effectivenessOutcomes of alcohol useLong-term opioid therapyManagement of chronic painCognitive behavioral therapy techniquesNational Institutes of HealthPain carePain interferenceCare providersMedication safetyHealthcare providersInstitutes of HealthSelf-managementAddiction Long-termHealth AdministrationLong-term opioid therapy trajectories in veteran patients with and without substance use disorder
Axson S, Becker W, Merlin J, Lorenz K, Midboe A, C Black A. Long-term opioid therapy trajectories in veteran patients with and without substance use disorder. Addictive Behaviors 2024, 153: 107997. PMID: 38442438, PMCID: PMC11080947, DOI: 10.1016/j.addbeh.2024.107997.Peer-Reviewed Original ResearchODD: A Benchmark Dataset for the Natural Language Processing Based Opioid Related Aberrant Behavior Detection
Kwon S, Wang X, Liu W, Druhl E, Sung M, Reisman J, Li W, Kerns R, Becker W, Yu H. ODD: A Benchmark Dataset for the Natural Language Processing Based Opioid Related Aberrant Behavior Detection. 2024, 4338-4359. DOI: 10.18653/v1/2024.naacl-long.244.Peer-Reviewed Original Research
2023
Are opioids effective analgesics and is physiological opioid dependence benign? Revising current assumptions to effectively manage long‐term opioid therapy and its deprescribing
Manhapra A, MacLean R, Rosenheck R, Becker W. Are opioids effective analgesics and is physiological opioid dependence benign? Revising current assumptions to effectively manage long‐term opioid therapy and its deprescribing. British Journal Of Clinical Pharmacology 2023, 90: 2962-2976. PMID: 37990580, PMCID: PMC11563311, DOI: 10.1111/bcp.15972.Peer-Reviewed Original ResearchLong-term opioid therapyOpioid therapyFunctional gainsChronic pain syndromeMaximum functional recoveryOngoing opioid crisisParadoxical worseningAnalgesic benefitAnalgesic therapyPain reliefPain syndromeEffective analgesicMost patientsAntinociceptive effectAntinociceptive systemChronic painFunctional recoveryOpioid actionOpioid dependenceMedical instabilityFunctional improvementPlacebo effectClinical principlesOpioid crisisTherapeutic inductionThe design and baseline characteristics for the HOPE Consortium Trial to reduce pain and opioid use in hemodialysis
Dember L, Hsu J, Bernardo L, Cavanaugh K, Charytan D, Crowley S, Cukor D, Doorenbos A, Edwards D, Esserman D, Fischer M, Jhamb M, Joffe S, Johansen K, Kalim S, Keefe F, Kimmel P, Krebs E, Kuzla N, Mehrotra R, Mishra P, Pellegrino B, Steel J, Unruh M, White D, Yabes J, Becker W, Consortium F. The design and baseline characteristics for the HOPE Consortium Trial to reduce pain and opioid use in hemodialysis. Contemporary Clinical Trials 2023, 136: 107409. PMID: 38086444, PMCID: PMC10922728, DOI: 10.1016/j.cct.2023.107409.Peer-Reviewed Original ResearchThe Association of Prescribed Opioids and Incident Cardiovascular Disease
Sung M, Eden S, Becker W, Crystal S, Duncan M, Gordon K, Kerns R, Kundu S, Freiberg M, So-Armah K, Edelman E. The Association of Prescribed Opioids and Incident Cardiovascular Disease. Journal Of Pain 2023, 25: 104436. PMID: 38029949, PMCID: PMC11058015, DOI: 10.1016/j.jpain.2023.11.019.Peer-Reviewed Original ResearchIncident cardiovascular diseaseModifiable CVD risk factorsCVD risk factorsHuman immunodeficiency virusCardiovascular diseasePrescribed opioidsOpioid receiptRisk factorsUse disordersCox proportional hazards regression modelVeterans Aging Cohort StudyVeterans Health Administration (VHA) carePropensity scoreProportional hazards regression modelsCVD incidence ratesPrescription opioid exposureIncident CVD eventsPrevalence of hypertensionAging Cohort StudyHigher opioid dosesOpioid use disorderHazards regression modelsNational prospective cohortVeterans Administration dataCocaine use disorderPaths Forward for Clinicians Amidst the Rise of Unregulated Clinical Decision Support Software: Our Perspective on NarxCare
Buonora M, Axson S, Cohen S, Becker W. Paths Forward for Clinicians Amidst the Rise of Unregulated Clinical Decision Support Software: Our Perspective on NarxCare. Journal Of General Internal Medicine 2023, 39: 858-862. PMID: 37962733, PMCID: PMC11043299, DOI: 10.1007/s11606-023-08528-2.Peer-Reviewed Original ResearchClinical decision support toolClinical decision support softwareHealthcare institutionsOpioid prescribingOverdose epidemicPatient encountersIndividual cliniciansPatient careProprietary formulaRigorous external validationCliniciansWider implementationExternal validationPrescribingPotential harmSufficient evidencePublic healthDecision support softwareDecision support toolSpecific actionsMortalityCareA Tool to Identify and Engage Patients on Risky Opioid Regimens
Griffin A, Perez T, Avoundjian T, Becker W, Midboe A. A Tool to Identify and Engage Patients on Risky Opioid Regimens. Applied Clinical Informatics 2023, 14: 1018-1026. PMID: 38151042, PMCID: PMC10752654, DOI: 10.1055/s-0043-1777126.Peer-Reviewed Original ResearchConceptsMedication regimensHigh-risk patient populationHigh-dose opioidsHigh-risk opioidPrimary care clinicsPrimary care appointmentsPrimary care staffPatient-centered careHealth care systemClinical informatics toolsOutreach letterOpioid regimensCare appointmentsCare clinicsChronic painOpioid safetyPatient populationCase reportClinic staffPatientsRegimensClinical initiativesCare staffCare initiativesOpioidsNIH HEAL Common Data Elements (CDE) implementation: NIH HEAL Initiative IDEA-CC
Adams M, Hurley R, Siddons A, Topaloglu U, Wandner L, Adams M, Arnsten J, Bao Y, Barry D, Becker W, Fiellin D, Fox A, Ghiroli M, Hanmer J, Horn B, Hurlocker M, Jalal H, Joseph V, Merlin J, Murray-Krezan C, Pearson M, Rogal S, Starrels J, Bachrach R, Witkiewitz K, Vasquez A. NIH HEAL Common Data Elements (CDE) implementation: NIH HEAL Initiative IDEA-CC. Pain Medicine 2023, 24: 743-749. PMID: 36799548, PMCID: PMC10321760, DOI: 10.1093/pm/pnad018.Peer-Reviewed Original ResearchConceptsClinical trialsClinical Trials NetworkCDE programsChronic painSecondary data analysisPainTrials NetworkDisease statesOpioidData standardsGeographical codingClinical researchHealing initiationData elementsNational InstituteTrialsDisordersFederal investmentInterventionStandard processDisorder researchSurveyed librariesCDELeveraging toolsNetwork alignment