2003
Midbrain serotonergic neurons are central pH chemoreceptors
Severson CA, Wang W, Pieribone VA, Dohle CI, Richerson GB. Midbrain serotonergic neurons are central pH chemoreceptors. Nature Neuroscience 2003, 6: 1139-1140. PMID: 14517544, DOI: 10.1038/nn1130.Peer-Reviewed Original Research
2002
Chemosensitive serotonergic neurons are closely associated with large medullary arteries
Bradley S, Pieribone V, Wang W, Severson C, Jacobs R, Richerson G. Chemosensitive serotonergic neurons are closely associated with large medullary arteries. Nature Neuroscience 2002, 5: 401-402. PMID: 11967547, DOI: 10.1038/nn848.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArteriesChemoreceptor CellsMedulla OblongataNeuronsRatsSerotoninTryptophan HydroxylaseConceptsSudden infant death syndromeSerotonergic neuronsArterial blood CO2Central respiratory chemoreceptorsInfant death syndromePatch-clamp recordingsMedullary arteriesRat medullaBrain slicesDeath syndromeRespiratory chemoreceptorsLarge arteriesTryptophan hydroxylaseBrain functionNeuronsBlood CO2ArteryDevelopmental abnormalitiesMedullaConfocal imagingAnatomical specializationsSyndromeAbnormalitiesNeurons1
2000
Multiple messengers in descending serotonin neurons: localization and functional implications
Hökfelt T, Arvidsson U, Cullheim S, Millhorn D, Nicholas A, Pieribone V, Seroogy K, Ulfhake B. Multiple messengers in descending serotonin neurons: localization and functional implications. Journal Of Chemical Neuroanatomy 2000, 18: 75-86. PMID: 10708921, DOI: 10.1016/s0891-0618(99)00037-x.Peer-Reviewed Original ResearchConceptsGamma-amino butyric acidSerotonin neuronsInhibitory neurotransmitter gamma-amino butyric acidNeurotransmitter gamma-amino butyric acidRaphe serotonin neuronsPost-synaptic actionsParticular substance PNumber of neuropeptidesSerotonin projectionsDorsal hornVentral hornSubstance PSpinal cordSame neuronsRostral levelsSuch neuronsNeuronsEnzyme glutaminasePresent review articleGlutamateRecent studiesReview articleFunctional implicationsWide spectrumHorn
1998
Galanin–5-hydroxytryptamine interactions: electrophysiological, immunohistochemical and in situ hybridization studies on rat dorsal raphe neurons with a note on galanin R1 and R2 receptors
Xu Z, Zhang X, Pieribone VA, Grillner S, Hökfelt T. Galanin–5-hydroxytryptamine interactions: electrophysiological, immunohistochemical and in situ hybridization studies on rat dorsal raphe neurons with a note on galanin R1 and R2 receptors. Neuroscience 1998, 87: 79-94. PMID: 9722143, DOI: 10.1016/s0306-4522(98)00151-1.Peer-Reviewed Original ResearchConceptsDorsal raphe neuronsRaphe neuronsRat dorsal raphe neuronsCell bodiesOutward currentsInhibitory effectGalanin-like immunoreactivityDorsal raphe nucleusDose-dependent hyperpolarizationExtracellular potassium concentrationGalaninergic mechanismsSitu hybridization studiesGalanin receptorsRaphe nucleusSynaptic contactsNerve endingsPostsynaptic receptorsSoma levelGalaninImmunohistochemical analysisR2 receptorsGalanin R1NeuronsMood regulationPhysiological concentrations
1995
Synaptic Vesicle Depletion in Reticulospinal Axons is Reduced by 5‐hydroxytryptamine: Direct Evidence for Presynaptic Modulation of Glutamatergic Transmission
Shupliakov O, Pieribone VA, Gad H, Brodin L. Synaptic Vesicle Depletion in Reticulospinal Axons is Reduced by 5‐hydroxytryptamine: Direct Evidence for Presynaptic Modulation of Glutamatergic Transmission. European Journal Of Neuroscience 1995, 7: 1111-1116. PMID: 7613617, DOI: 10.1111/j.1460-9568.1995.tb01099.x.Peer-Reviewed Original ResearchConceptsReticulospinal axonsPresynaptic Ca2Glutamatergic synaptic transmissionSynaptic glutamate releaseSynaptic vesiclesIntra-axonal recordingsGiant reticulospinal axonsSynaptic vesicle clustersGlutamatergic transmissionPresynaptic modulationGlutamate releaseSpinal cordPresynaptic elementsSynaptic transmissionAction potential stimulationSynaptic vesicle depletionSame axonVesicle depletionAxonsMarked reductionNumber of vesiclesPotential stimulationSynaptic exocytosisActive zoneCa2
1994
Immunohistochemical analysis of the relation between 5‐hydroxytryptamine‐ and neuropeptide‐immunoreactive elements in the spinal cord of an amphibian (Xenopus laevis)
Pieribone V, Brodin L, Hökfelt T. Immunohistochemical analysis of the relation between 5‐hydroxytryptamine‐ and neuropeptide‐immunoreactive elements in the spinal cord of an amphibian (Xenopus laevis). The Journal Of Comparative Neurology 1994, 341: 492-506. PMID: 7515401, DOI: 10.1002/cne.903410406.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptidePeptide-immunoreactive fibersCorticotropin-releasing factorSubstance PSpinal cordImmunoreactive fibersXenopus laevis spinal cordCCK-immunoreactive fibersGene-related peptideCRF-immunoreactive fibersLabeling of fibersDouble-labeling techniqueGAL immunoreactivitySpinal transectionPeptide immunoreactivityImmunohistochemical analysisGalaninImmunohistochemical dataRostrocaudal levelsCordIntact animalsSimilar negative resultsImmunoreactive materialImmunofluorescence double-labeling techniqueCholecystokinin
1992
Serotonin-, substance P- and glutamate/aspartate-like immunoreactivities in medullo-spinal pathways of rat and primate
Nicholas AP, Pieribone VA, Arvidsson U, Hökfelt T. Serotonin-, substance P- and glutamate/aspartate-like immunoreactivities in medullo-spinal pathways of rat and primate. Neuroscience 1992, 48: 545-559. PMID: 1376453, DOI: 10.1016/0306-4522(92)90401-m.Peer-Reviewed Original ResearchConceptsAspartate-like immunoreactivityExcitatory amino acidsSubstance PColchicine-treated ratsSpinal cordLarger alpha motor neuronsB3 cell groupSubstance P neuronsAlpha motor neuronsGlutamate-like immunoreactivityTripeptide thyrotropin-releasing hormoneDistribution of serotoninThyrotropin-releasing hormoneUndecapeptide substance PImmunohistofluorescence techniqueMedullary neuronsImmunoreactive neuronsRaphe neuronsVentral hornRetrograde tracingSerotonergic neuronsMedulla oblongataSpinal projectionsLarge boutonsAutonomic cells