2024
The association of higher offspring early‐childhood weight gain with prepregnancy metabolic and bariatric surgery
Hilaire M, Babcock A, White G, Masson C, Salem R, Reddy U, Gallagher D, LeDuc C, Thaker V. The association of higher offspring early‐childhood weight gain with prepregnancy metabolic and bariatric surgery. Obesity 2024, 32: 2012-2023. PMID: 39497631, DOI: 10.1002/oby.24166.Peer-Reviewed Original ResearchConceptsOffspring growth trajectoriesBariatric surgeryHypertensive disorders of pregnancyWorld Health Organization Child Growth StandardsRoux-en-Y gastric bypassWeight gainHigher BMI z-scoreEarly-life weight gainNon-MB groupDisorders of pregnancyGestational diabetes mellitusGestational weight gainLow birth weightBMI z-scoreChild Growth StandardsScore-matched controlsPrepregnancy BMIGestational outcomesHypertensive disordersSleeve gastrectomyGastric bypassBirth weightPrepregnancyDiabetes mellitusGrowth standardsDesign, rationale and protocol for Glycemic Observation and Metabolic Outcomes in Mothers and Offspring (GO MOMs): an observational cohort study
Group T, Scholtens D, LeBlanc E, Vesco K, Amy D, Bays K, Massimino S, Robinson S, Schell K, Walters G, Hillier T, Oshiro C, Cordero S, Howick C, Kim L, Martinez Y, Pishchalenko O, Wastlova V, Zork N, Mourad M, Lonier J, Reddy U, Acevedo J, Castillo J, Gomez M, Peguero B, Facco F, Feghali M, Bocan H, Stramowski S, Powe C, Edlow A, Barth W, Nathan D, Azevedo R, Baez A, Iroajanma C, Larkin M, Maya J, Michalopoulos C, Neamonitaki N, Thangthaeng N, Yee L, Lowe W, Grobman W, Szmuilowicz E, Aguirre A, Guevara E, Mallett G, Matos S, Tyagi S, Spadola A, Catalano P, Azimirad A, Werner E, Rouse D, Malloy M, Parra F, Sherr J, Merriam A, Bitterman S, Considine E, Leventhal J, Perley L, Rink L, Steffen A, Thompson B, Zgorski M, Steffes M, Arends V, Killeen A, Siddique J, Bustamante P, Cheung Y, Freeze C, Grott T, Kuang A, Tull M, Linder B. Design, rationale and protocol for Glycemic Observation and Metabolic Outcomes in Mothers and Offspring (GO MOMs): an observational cohort study. BMJ Open 2024, 14: e084216. PMID: 38851233, PMCID: PMC11163666, DOI: 10.1136/bmjopen-2024-084216.Peer-Reviewed Original ResearchConceptsLarge-for-gestational-age birth weightMetabolic outcomesLarge-for-gestational-ageDiagnosis of gestational diabetesOral glucose tolerance testAdverse pregnancy outcomesVanderbilt University Institutional Review BoardCourse of pregnancyObservational cohort studyGlucose tolerance testNational Institute of DiabetesDigestive and Kidney DiseasesGDM treatmentWeeks gestationDetect such abnormalitiesPerinatal outcomesGDM screeningInstitutional review boardGestational diabetesFirst-trimesterPregnancy outcomesEarly pregnancyGlucose abnormalitiesBirth weightPregnant adultsGenetic polymorphisms associated with adverse pregnancy outcomes in nulliparas
Khan R, Guerrero R, Wapner R, Hahn M, Raja A, Salleb-Aouissi A, Grobman W, Simhan H, Silver R, Chung J, Reddy U, Radivojac P, Pe’er I, Haas D. Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas. Scientific Reports 2024, 14: 10514. PMID: 38714721, PMCID: PMC11076516, DOI: 10.1038/s41598-024-61218-9.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAdverse pregnancy outcomesMulti-ancestry genome-wide association studyCluster of SNPsGestational diabetesPregnancy outcomesAdmixed AmericansNovel lociPregnancy lossAssociation studiesGenetic markersIncreased risk of pregnancy lossTRMU geneGenetic ancestryAssociated with gestational diabetesRisk of pregnancy lossSub-cohortProportion of pregnanciesCause of morbidityLociAssociation TestSNPsPreterm birthMaternal riskIncreased riskAdverse Pregnancy Outcomes and Predicted 30-Year Risk of Maternal Cardiovascular Disease 2–7 Years After Delivery
Venkatesh K, Khan S, Yee L, Wu J, McNeil R, Greenland P, Chung J, Levine L, Simhan H, Catov J, Scifres C, Reddy U, Pemberton V, Saade G, Merz C, Grobman W, Mothers-to-Be A. Adverse Pregnancy Outcomes and Predicted 30-Year Risk of Maternal Cardiovascular Disease 2–7 Years After Delivery. Obstetrics And Gynecology 2024, 143: 775-784. PMID: 38574364, PMCID: PMC11098696, DOI: 10.1097/aog.0000000000005569.Peer-Reviewed Original ResearchConceptsRisk of atherosclerotic CVDAtherosclerotic CVD riskAdverse pregnancy outcomesHypertensive disorders of pregnancyAtherosclerotic CVDCVD riskDisorders of pregnancyPregnancy outcomesHypertensive disordersPreterm birthModified Poisson modelsFramingham risk scoreRisk of CVDRisk of atherosclerotic cardiovascular diseaseMagnitude of riskAbsolute riskAtherosclerotic cardiovascular diseaseSecondary analysisLongitudinal cohortRisk scoreGestational ageGreater riskBaseline covariatesCardiovascular diseaseDisease 2
2023
Researching COVID to enhance recovery (RECOVER) pregnancy study: Rationale, objectives and design
Metz T, Clifton R, Gallagher R, Gross R, Horwitz L, Jacoby V, Martin-Herz S, Peralta-Carcelen M, Reeder H, Beamon C, Chan J, Chang A, Costantine M, Fitzgerald M, Foulkes A, Gibson K, Güthe N, Habli M, Hackney D, Hoffman M, Hoffman M, Hughes B, Katz S, Laleau V, Mallett G, Mendez-Figueroa H, Monzon V, Palatnik A, Palomares K, Parry S, Pettker C, Plunkett B, Poppas A, Reddy U, Rouse D, Saade G, Sandoval G, Schlater S, Sciurba F, Simhan H, Skupski D, Sowles A, Thaweethai T, Thomas G, Thorp J, Tita A, Weiner S, Weigand S, Yee L, Flaherman V, Initiative O. Researching COVID to enhance recovery (RECOVER) pregnancy study: Rationale, objectives and design. PLOS ONE 2023, 18: e0285351. PMID: 38128008, PMCID: PMC10734909, DOI: 10.1371/journal.pone.0285351.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionSARS-CoV-2Long-term outcomesMonths of agePregnancy cohortMaternal-Fetal Medicine Units NetworkHealth outcomesSARS-CoV-2 antibody testingAdverse long-term outcomesEunice Kennedy Shriver National InstitutePost-acute sequelaeLong-term sequelaeClinical trial registrationMaternal-child dyadsNational InstituteMulti-site observational studyCalifornia San FranciscoUnique physiologic changesPregnancy modifiesMaternal infectionMultiple gestationsOverall cohortRetrospective cohortAntibody testingLong COVIDCervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix
Hoffman M, Clifton R, Biggio J, Saade G, Ugwu L, Longo M, Bousleiman S, Clark K, Grobman W, Frey H, Chauhan S, Dugoff L, Manuck T, Chien E, Rouse D, Simhan H, Esplin M, Macones G, Bickus M, Facco F, Tita A, Grant J, Casey B, Harris S, Harper L, Dunn D, Longo S, Hendricks M, Lata-Arias K, Costantine M, Bartholomew A, Cline D, Harper S, Ward C, Gardner N, Brindle S, Weigand S, McKenna D, Snow E, Fennig K, Habli M, Lambers D, McClellan M, Metz T, Sowles A, Varner M, Hill K, Morby V, Meadows C, Allard D, Werner E, Rousseau J, Milano J, Pettker C, Leventhal J, Gyamfi-Bannerman C, Wapner R, Carmona V, Firman B, Vanneman A, Palomares K, Beche I, Skupski D, Chan-Akeley R, Salazar A, Pacheco L, McCoy L, Saad A, Jain S, Omere C, Clifford C, McDonnold M, Chien E, Dalton W, Polito L, Milluzi C, Kushner K, Maile A, Bell J, Hackney D, Ortiz F, Timlin S, Goodnight W, Manuck T, Beamon C, Nun H, Eichelberger K, Moore A, Hughes B, Ferrara J, Grobman W, Mallett G, Stein L, Miller E, Plunkett B, Kearns K, Palatnik A, Malone T, Parry S, Pizzi C, Craig J, Filipczak A, Thom E, Doherty L, Hubbard A, Erikson P, Pinto T, Marcharchand P, Reddy U, Miodovnik M, Archer S. Cervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix. JAMA 2023, 330: 340-348. PMID: 37490086, PMCID: PMC10369212, DOI: 10.1001/jama.2023.10812.Peer-Reviewed Original ResearchConceptsCervical pessaryUsual carePreterm birthShort cervixVaginal progesteroneCervical lengthSingleton pregnanciesFetal deathPrimary outcomeInfant deathPrior spontaneous preterm birthTransvaginal ultrasound cervical lengthCervical pessary placementWeeks 0 daysSpontaneous preterm birthUltrasound cervical lengthWeeks 6 daysThird interim analysisNeonatal/infant mortalityPreterm deliverySingleton gestationsBaseline characteristicsUltrasound evidencePessary placementTransvaginal ultrasoundResearching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design
Horwitz L, Thaweethai T, Brosnahan S, Cicek M, Fitzgerald M, Goldman J, Hess R, Hodder S, Jacoby V, Jordan M, Krishnan J, Laiyemo A, Metz T, Nichols L, Patzer R, Sekar A, Singer N, Stiles L, Taylor B, Ahmed S, Algren H, Anglin K, Aponte-Soto L, Ashktorab H, Bassett I, Bedi B, Bhadelia N, Bime C, Bind M, Black L, Blomkalns A, Brim H, Castro M, Chan J, Charney A, Chen B, Chen L, Chen P, Chestek D, Chibnik L, Chow D, Chu H, Clifton R, Collins S, Costantine M, Cribbs S, Deeks S, Dickinson J, Donohue S, Durstenfeld M, Emery I, Erlandson K, Facelli J, Farah-Abraham R, Finn A, Fischer M, Flaherman V, Fleurimont J, Fonseca V, Gallagher E, Gander J, Gennaro M, Gibson K, Go M, Goodman S, Granger J, Greenway F, Hafner J, Han J, Harkins M, Hauser K, Heath J, Hernandez C, Ho O, Hoffman M, Hoover S, Horowitz C, Hsu H, Hsue P, Hughes B, Jagannathan P, James J, John J, Jolley S, Judd S, Juskowich J, Kanjilal D, Karlson E, Katz S, Kelly J, Kelly S, Kim A, Kirwan J, Knox K, Kumar A, Lamendola-Essel M, Lanca M, Lee-Lannotti J, Lefebvre R, Levy B, Lin J, Logarbo B, Logue J, Longo M, Luciano C, Lutrick K, Malakooti S, Mallett G, Maranga G, Marathe J, Marconi V, Marshall G, Martin C, Martin J, May H, McComsey G, McDonald D, Mendez-Figueroa H, Miele L, Mittleman M, Mohandas S, Mouchati C, Mullington J, Nadkarni G, Nahin E, Neuman R, Newman L, Nguyen A, Nikolich J, Ofotokun I, Ogbogu P, Palatnik A, Palomares K, Parimon T, Parry S, Parthasarathy S, Patterson T, Pearman A, Peluso M, Pemu P, Pettker C, Plunkett B, Pogreba-Brown K, Poppas A, Porterfield J, Quigley J, Quinn D, Raissy H, Rebello C, Reddy U, Reece R, Reeder H, Rischard F, Rosas J, Rosen C, Rouphael N, Rouse D, Ruff A, Saint Jean C, Sandoval G, Santana J, Schlater S, Sciurba F, Selvaggi C, Seshadri S, Sesso H, Shah D, Shemesh E, Sherif Z, Shinnick D, Simhan H, Singh U, Sowles A, Subbian V, Sun J, Suthar M, Teunis L, Thorp J, Ticotsky A, Tita A, Tragus R, Tuttle K, Urdaneta A, Utz P, VanWagoner T, Vasey A, Vernon S, Vidal C, Walker T, Ward H, Warren D, Weeks R, Weiner S, Weyer J, Wheeler J, Whiteheart S, Wiley Z, Williams N, Wisnivesky J, Wood J, Yee L, Young N, Zisis S, Foulkes A. Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design. PLOS ONE 2023, 18: e0286297. PMID: 37352211, PMCID: PMC10289397, DOI: 10.1371/journal.pone.0286297.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionRisk factorsClinical risk factorsPost-acute sequelaePrimary study outcomeProportional hazards regressionCommunity-based outreachMulti-site observational studyPASC symptomsQuarterly questionnairesRetrospective cohortVaccination statusOrgan dysfunctionAcute phaseLong COVIDHazards regressionEligible participantsTreatment optionsPrior infectionStudy protocolClinical trialsNew symptomsLongitudinal cohortLaboratory examinationsObservational studyLow-Dose Aspirin during Pregnancy and Postpartum Bleeding
White K, Son M, Lundsberg L, Culhane J, Partridge C, Reddy U, Merriam A. Low-Dose Aspirin during Pregnancy and Postpartum Bleeding. American Journal Of Perinatology 2023, 40: 1390-1397. PMID: 37211010, DOI: 10.1055/a-2096-5199.Peer-Reviewed Original ResearchConceptsLow-dose aspirinPostpartum blood lossTiming of discontinuationBlood lossPostpartum bleedingPostpartum hemorrhageLDA useUse of LDARed blood cell transfusionBlood cell transfusionRetrospective cohort studySystemic lupus erythematosusTime of deliveryDiagnosis of diabetesLogistic regression modelingElectronic medical recordsAspirin 81Ideal dosingPreeclampsia preventionCell transfusionDose aspirinCohort studyHypertensive diseaseLupus erythematosusPrimary outcomeDevelopment of a Definition of Postacute Sequelae of SARS-CoV-2 Infection
Thaweethai T, Jolley S, Karlson E, Levitan E, Levy B, McComsey G, McCorkell L, Nadkarni G, Parthasarathy S, Singh U, Walker T, Selvaggi C, Shinnick D, Schulte C, Atchley-Challenner R, Horwitz L, Foulkes A, Aberg J, Adolphi N, Ahirwar S, Ahmed S, Ahuja N, Aikawa M, Akerlundh A, Akintonwa T, Al-Jadiri A, Alekhina N, Algren H, Alshawabkeh A, Ammar N, Anand A, Anderson B, Aponte-Soto L, Aschner J, Atha M, Atz A, Aupperle R, Ayache M, Azziz-Baumgartner E, Bailey L, Baker F, Balaraman V, Bandy J, Banerjee D, Barch D, Bardes J, Barlocker J, Barr R, Baskin-Sommers A, Basu S, Battaglia T, Baucom L, Beamon C, Beaty C, Beckmann N, Berry J, Bhadelia N, Bhargava D, Bhuiyan S, Bian J, Bime C, Bjork J, Black L, Blish C, Block J, Bogie A, Bolliger D, Bonaventura W, Bose-Brill S, Bower M, Boyd A, Boyineni J, Bradfute S, Bramante C, Brannock M, Bremner J, Brosnahan S, Buchbinder N, Bueler E, Buhimschi I, Bukulmez H, Bunnell H, Buse J, Calhoun E, Cao T, Carrithers M, Carton T, Case A, Casey B, Casimero F, Castro L, Cato T, Ceger P, Cerullo C, Chang L, Chang A, Chebrolu P, Chen Y, Chen L, Chen B, Chestek D, Chew R, Chisolm D, Chow D, Chrisant M, Christakis D, Chute C, Cicek M, Clark C, Clark D, Clarke G, Clouser K, Connors T, Cook J, Coombs K, Cordon-Cardo C, Costello J, Cottrell L, Cowan K, Cowell L, Cranford S, Cronin J, Cummins M, Curry H, D'Sa V, Dabney S, Daniel C, Dapretto M, Darbar D, Darden P, Dasgupta R, Dasgupta S, Davis Blakley F, Dea K, Deakyne Davies S, Decker L, DeFronzo R, Dehority W, Deitchman A, del Alcazar J, Del Boccio P, del Rio C, Del Rios M, DeLisa J, Deoni S, Diaz M, Dickinson J, Dionne A, Diviak K, Donohue S, Downey M, Dozor A, Dreyer B, Dummer K, Durstenfeld M, Dworkin M, Edmonds S, Elias M, Elifritz J, Ellingworth E, Elliott A, Ellison A, Enger M, Espinosa J, Esquenazi-Karonika S, Evans M, Evans D, Facelli J, Fang C, Faustino E, Fayad Lara M, Feldman C, Fiks A, Fineman R, Finn A, Fischer M, Fitzgerald M, Flaherman V, Flotte T, Forsha D, Fortune M, Foxe J, Franks N, Freedman M, Freeland C, Friedman N, Fry G, Gage Witvliet M, Gallagher E, Gallagher R, Garavan H, Gaur S, Gee D, Gennaro M, Gerald L, Ghosh S, Giacino J, Girvin A, Godfrey S, Goldberg M, Goodman S, Gordon H, Gouripeddi R, Graham P, Granger J, Gray K, Greimes T, Gross R, Guthe N, Gutter E, Haasnoot S, Hadley E, Haendel M, Hafner S, Halabi K, Hanley P, Harahsheh A, Harkins M, Hartwig K, Hasbani K, Hasek S, Hauser K, Heath A, Hebson C, Heitzeg M, Hendrickson M, Henrich T, Hernandez-Romieu A, Hester C, Higginbotham M, Hill S, Hirabayashi K, Ho O, Hobart-Porter L, Hoffman M, Holtcamp M, Hong T, Horne B, Horowitz C, Hsia D, Hsu H, Hsue P, Huentelman M, Huerta B, Huling J, Hummel K, Iacono W, Ibanez A, Ibeawuchi C, Irby K, Ismail N, Jacobus J, Jacoby V, Jason L, Javia V, Jennette K, Jernigan T, Jiang S, Jing N, Johnny J, Johnson N, Johnson B, Johnson B, Jone P, Judd S, Juskowich J, Kabagambe E, Kaelber D, Kanjilal D, Kansal M, Kasmarcak T, Kaufman D, Kawakami R, Kellogg D, Kent D, Kewlani D, Khullar D, Kim K, Kim A, Kinser P, Kleinman L, Klerman E, Kluko M, Knight S, Kobayashi M, Kopp K, Koropsak M, Kosut J, Kraig E, Krausert A, Krieger A, Krishna H, Krishnamoorthy A, Krishnan S, Lahs J, Laird A, Laleau V, Lamendola-Essel M, Landeo-Gutierrez J, Lang S, Larson C, Lash J, Lasky-Su J, Laynor G, Lee S, Lee G, Lee F, Lee M, Leese P, Lefebvre R, Levreault A, Lewis K, Li L, Lim P, Lin J, Lisdahl K, Litvack M, Liu X, Lloyd J, Logue J, Loomba J, Lorman V, Lu Y, Ludwig K, Lutz A, Mack J, Mahmoud A, Maier C, Malakooti S, Malchenko S, Mallett G, Maranga G, Martel M, Martin-Herz S, Martinez-Lage M, Maughan C, Mauntel-Medici C, May H, Mayer K, Mazzotti D, McCallum C, McCrindle B, McCulloh R, McDonald D, McInnis S, McMurry J, Mejias A, Melamed J, Menchaca M, Mendelsohn A, Miele L, Miglis M, Milne C, Milner J, Mitchell R, Mittleman M, Mohandas S, Monteiro J, Monzon V, Moreno D, Morgan L, Morozyuk D, Morse K, Moyneur E, Mudumbi P, Müller-Oehring E, Muramatsu N, Musick H, Nagavedu K, Nahin E, Nambiar A, Natelson B, Neale M, Ness-Cochinwala M, Newburger J, Newman L, Nguyen A, Nichols L, Nolan S, Noland S, Novak R, O'Connor G, O'Keefe J, Ogbogu P, Oliveira C, Oster M, Padera R, Paik H, Pajor N, Pan H, Pant D, Partridge A, Patel P, Patel S, Patel K, Paulus M, Payne R, Pearman A, Peralta-Carcelen M, Perez N, Pfaff E, Pillers D, Pitsch C, Pliskin N, Portman M, Postelnicu R, Potter J, Prabhakar B, Prahalad P, Prasad B, Predki B, Preiss A, Prendergast H, Quinn D, Quintana Y, Rabideau D, Radosta J, Radwell J, Raissy H, Ramchandran R, Randall I, Rao S, Rapkiewicz A, Rasmussen S, Razzaghi H, Rebello C, Rebolledo P, Reddy N, Reddy U, Reedy C, Rehman J, Reichard R, Reid K, Reusch J, Rhee K, Rice M, Rizzo J, Roan N, Robarts P, Roberts T, Rochez N, Rodgers K, Rogerson C, Romero M, Rosas J, Rosenzweig E, Rothman R, Rouphael N, Russell M, Rutherfoord M, Sabati A, Sader S, Salehi M, Salisbury A, Sampson B, Sanil Y, Sato A, Saydah S, Schechter M, Schenck E, Schlepphorst K, Schuchard J, Schuh T, Sculley J, Seifert A, Sekar A, Selvarangan R, Seshadri S, Sesso H, Shah D, Shakti D, Shapiro N, Sharma S, Sharma K, Sharma S, Sharma K, Shaw G, Shemesh E, Shen Y, Shenkman E, Shiau S, Siciliano M, Simsir A, Smith V, Snowden J, Solomon I, Spikes L, Squeglia L, Srivastava S, St. Jean M, Stapleford K, Stein C, Stevenson M, Stewart de Ramirez S, Stiles L, Stock A, Stockwell M, Stone J, Stratford J, Stürmer T, Subbian V, Sun J, Suthar M, Sylvera A, Systrom D, Szmuszkovicz J, Talavera-Barber M, Tantisira K, Tartt N, Terlinde T, Teufel R, Thacker D, Thakrar M, Thibodeau S, Thomas G, Thomason M, Tong J, Torres R, Traenkner J, Tragus R, Trinity J, Tronieri J, Troxel A, Truong J, Truong D, Tsevat J, Udosen M, Unterberger K, Utz P, Vaccarino V, Vallejos B, Vanden Hoek T, Vangeepuram N, Varma J, Vernon S, Vidal C, Vivensi S, Vohra A, Wagner L, Wang F, Warburton D, Warner M, Watkins R, Watson S, Webb R, Weeks R, Weiner M, Werzberger A, West S, Weyer J, Wheeler J, Wilkins K, Williams N, Williams C, Wimberly E, Winter T, Woller S, Wong R, Wood J, Wood J, Wood M, Wu Q, Xia Y, Xu J, Yang S, Yin H, Yin H, Yoo Y, Young C, Young N, Zang C, Zempsky W, Zhang B, Zhang Y, Zhang D, Zimmerman E, Andrefsky J, Marrazzo J, Dixon J, Gale L, Maholovich P, Sudhindra P, Thompson T, Sheehan E, Parada A, Knowlton K, Anderson J, McIntyre M, McCandless S, Montoya S, Davis D, Spanier E, Wodushek T, Sokol R, Maldonado Y, Jacobson K, Jia X, Scott J, Quintero O, Haddad F, Valantine H, Zamanian R, Pathak D, Boyce J, Facco F, Hankle S, Vargo J, Campbell D, Armstrong D, Mann M, Burrell N, Bartholomew A, Grobman W, Cackovic B, Klopfenstein B, Weigand S, Snow E, Fennig K, Esplin M, Lamb D, Nelsen A, Phipers J, Fischer L, Docter O, Brown J, DeMartino A, Allard D, Miller E, Bousleiman S, Loffredo M, Vanneman A, Beche I, Chan-Akeley R, Pacheco L, DeVolder J, Salazar A, Thibodeaux L, Cornwell J, Nounes A, Sweet E, Pierse A, Desantis B, Gill-Jones P, Hackney D, Chauhan S, Ortiz F, Treadway J, Rugerio J, Clark K, Leatherland M, Timlin S, Grinnan C, Ferrara J, Kominiarek M, Jones D, Reynolds T, Kearns K, Saffian E, Karasti M, Pizzi C, Filipczak A, Long E, Mitchell M, Barrett K, Mullowney C, Macones G, Alba G, Alicic R, Altman N, Anglin K, Argueta U, Ashktorab H, Baslet G, Bassett I, Bateman L, Bedi B, Bhattacharyya S, Bind M, Blomkalns A, Bonilla H, Brim H, Bush P, Castro M, Chan J, Charney A, Chen P, Chibnik L, Chu H, Clifton R, Costantine M, Cribbs S, Davila Nieves S, Deeks S, Duven A, Emery I, Erdmann N, Erlandson K, Ernst K, Farah-Abraham R, Farner C, Feuerriegel E, Fleurimont J, Fonseca V, Franko N, Gainer V, Gander J, Gardner E, Geng L, Gibson K, Go M, Goldman J, Grebe H, Greenway F, Habli M, Hafner J, Han J, Hanson K, Heath J, Hernandez C, Hess R, Hodder S, Hoffman M, Hoover S, Huang B, Hughes B, Jagannathan P, John J, Jordan M, Katz S, Kaufman E, Kelly J, Kelly S, Kemp M, Kirwan J, Klein J, Knox K, Krishnan J, Kumar A, Laiyemo A, Lambert A, Lanca M, Lee-Iannotti J, Logarbo B, Longo M, Luciano C, Lutrick K, Maley J, Mallett G, Marathe J, Marconi V, Marshall G, Martin C, Matusov Y, Mehari A, Mendez-Figueroa H, Mermelstein R, Metz T, Morse R, Mosier J, Mouchati C, Mullington J, Murphy S, Neuman R, Nikolich J, Ofotokun I, Ojemakinde E, Palatnik A, Palomares K, Parimon T, Parry S, Patterson J, Patterson T, Patzer R, Peluso M, Pemu P, Pettker C, Plunkett B, Pogreba-Brown K, Poppas A, Quigley J, Reddy U, Reece R, Reeder H, Reeves W, Reiman E, Rischard F, Rosand J, Rouse D, Ruff A, Saade G, Sandoval G, Santana J, Schlater S, Sciurba F, Shepherd F, Sherif Z, Simhan H, Singer N, Skupski D, Sowles A, Sparks J, Sukhera F, Taylor B, Teunis L, Thomas R, Thorp J, Thuluvath P, Ticotsky A, Tita A, Tuttle K, Urdaneta A, Valdivieso D, VanWagoner T, Vasey A, Verduzco-Gutierrez M, Wallace Z, Ward H, Warren D, Weiner S, Welch S, Whiteheart S, Wiley Z, Wisnivesky J, Yee L, Zisis S. Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection. JAMA 2023, 329: 1934-1946. PMID: 37278994, PMCID: PMC10214179, DOI: 10.1001/jama.2023.8823.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionCohort studyPostacute sequelaeProspective observational cohort studyAcute symptom onsetObservational cohort studyProspective cohort studyAdjusted odds ratioDays of infectionSelf-reported symptomsSurvey 6 monthsNumber of infectionsBrain fogChest painChronic coughGastrointestinal symptomsSymptom onsetVaccination statusAcute infectionPostexertional malaiseClinical featuresLong COVIDNew symptomsOdds ratioAbnormal movements
2022
Association of a Mediterranean Diet Pattern With Adverse Pregnancy Outcomes Among US Women
Makarem N, Chau K, Miller E, Gyamfi-Bannerman C, Tous I, Booker W, Catov J, Haas D, Grobman W, Levine L, McNeil R, Merz C, Reddy U, Wapner R, Wong M, Bello N. Association of a Mediterranean Diet Pattern With Adverse Pregnancy Outcomes Among US Women. JAMA Network Open 2022, 5: e2248165. PMID: 36547978, PMCID: PMC9857221, DOI: 10.1001/jamanetworkopen.2022.48165.Peer-Reviewed Original ResearchConceptsAdverse pregnancy outcomesMediterranean diet patternTime of conceptionPregnancy outcomesDiet patternLower oddsAMED scoresGestational diabetesCohort studyUS womenLower riskRisk of APOsPrepregnancy body mass indexCardiovascular disease risk factorsSemiquantitative food frequency questionnaireAlternate Mediterranean diet scoreNulliparous Pregnancy Outcomes StudyLowest AMED scoresGestational age infantsDisease risk factorsDose-response associationFood frequency questionnaireMediterranean diet scoreBody mass indexCause of morbidityAssociation of N-Terminal Pro–Brain Natriuretic Peptide Concentration in Early Pregnancy With Development of Hypertensive Disorders of Pregnancy and Future Hypertension
Hauspurg A, Marsh D, McNeil R, Bairey Merz C, Greenland P, Straub A, Rouse C, Grobman W, Pemberton V, Silver R, Chen Y, Mercer B, Levine L, Hameed A, Hoffman M, Simhan H, Catov J, Reddy U, Willinger M, Davis M, Laposky A, Iams J, Dalton W, Latimer C, Polito L, Louis J, Wapner R, Fuchs K, Torres C, Lynch S, Onativia A, DiVito M, Nhan-Chang C, Basner R, Haas D, Foroud T, Perkins E, Barnes S, Winters A, McCormick C, Schubert F, Caritis S, Bickus M, Speer P, Emery S, Daftary A, Facco F, Peaceman A, Zee P, Campbell P, Shepard J, Williams C, Wing D, Wadhwa P, Nageotte M, Chung J, Rumney P, Porto M, Pham V, Parry S, Ludmir J, Elovitz M, Peters M, Araujo B, Pien G, Esplin M, Vorwaller K, Postma J, Morby V, Williams M, Meadows L, Parker C, Koch M, McFadden D, Alexander B, Yetukuri V, Hunter S, Holder T, Franklin H, DeCain M, Griggs C, Redline S, Mobley D, Surovec S, Ulanski J, Saade G. Association of N-Terminal Pro–Brain Natriuretic Peptide Concentration in Early Pregnancy With Development of Hypertensive Disorders of Pregnancy and Future Hypertension. JAMA Cardiology 2022, 7: 268-276. PMID: 35044418, PMCID: PMC8771430, DOI: 10.1001/jamacardio.2021.5617.Peer-Reviewed Original ResearchConceptsHigher NT-proBNP concentrationsNT-proBNP concentrationsHypertensive disordersSubclinical cardiac dysfunctionEarly pregnancyYear post partumHypertension 2Lower riskPregnancy outcomesCohort studyCardiac dysfunctionNatriuretic peptideN-terminal pro-brain natriuretic peptide concentrationN-terminal pro-brain natriuretic peptideEarly pregnancy body mass indexProspective multicenter observational studyPro-brain natriuretic peptidePost partumNulliparous Pregnancy Outcomes StudyFirst-trimester blood samplesAdverse pregnancy outcomesMulticenter observational studyFuture cardiovascular diseaseNatriuretic peptide concentrationsCardiovascular disease risk
2021
Maternal serum fructosamine levels and stillbirth: a case–control study of the Stillbirth Collaborative Research Network
Arslan E, Allshouse A, Page J, Varner M, Thorsten V, Parker C, Dudley D, Saade G, Goldenberg R, Stoll B, Hogue C, Bukowski R, Conway D, Pinar H, Reddy U, Silver R. Maternal serum fructosamine levels and stillbirth: a case–control study of the Stillbirth Collaborative Research Network. BJOG An International Journal Of Obstetrics & Gynaecology 2021, 129: 619-626. PMID: 34529344, DOI: 10.1111/1471-0528.16922.Peer-Reviewed Original ResearchConceptsSerum fructosamine levelsFructosamine levelsCase-control studyTime of deliveryLive birthsStillbirth Collaborative Research NetworkLive birth controlsCases of stillbirthPotential confounding factorsGeographic catchment areaSingleton stillbirthsGlycaemic controlDiabetes statusMulticentre studyRoutine screeningFructosamine measurementsDiabetesStillbirthConfounding factorsSecondary analysisWomenBirthCollaborative research networksBirth controlResearch NetworkChronic hypertension, perinatal mortality and the impact of preterm delivery: a population‐based study
Grover S, Brandt J, Reddy U, Ananth C. Chronic hypertension, perinatal mortality and the impact of preterm delivery: a population‐based study. BJOG An International Journal Of Obstetrics & Gynaecology 2021, 129: 572-579. PMID: 34536318, PMCID: PMC9214277, DOI: 10.1111/1471-0528.16932.Peer-Reviewed Original ResearchConceptsPerinatal mortality rateChronic hypertensionEarly term deliveryPreterm deliveryPerinatal mortalityMortality rateTerm deliverySingleton birthsCausal mediation analysisMaternal chronic hypertensionElevated blood pressureModifiable risk factorsPopulation-based studyWeeks of gestationLate-term gestationCross-sectional analysisNormotensive pregnanciesPreterm birthBlood pressureTerm gestationPerinatal deathRisk factorsHypertensionMAIN OUTCOMEMortalityOutcomes in Twins Compared With Singletons Subsequent to Preterm Prelabor Rupture of Membranes
Bartal M, Ugwu LG, Grobman WA, Bailit JL, Reddy UM, Wapner RJ, Varner MW, Thorp JM, Caritis SN, Prasad M, Tita ATN, Saade GR, Rouse DJ. Outcomes in Twins Compared With Singletons Subsequent to Preterm Prelabor Rupture of Membranes. Obstetrics And Gynecology 2021, 138: 725-731. PMID: 34619719, PMCID: PMC8542618, DOI: 10.1097/aog.0000000000004561.Peer-Reviewed Original ResearchMeSH KeywordsAdultChorioamnionitisCohort StudiesEndometritisEnterocolitis, NecrotizingFemaleFetal Membranes, Premature RuptureGestational AgeHumansInfant, NewbornInfant, PrematureOutcome Assessment, Health CarePerinatal MortalityPregnancyPregnancy OutcomePregnancy, TwinPremature BirthSepsisVenous ThromboembolismWound InfectionYoung AdultConceptsComposite maternal morbidityPreterm prelabor ruptureWeeks of gestationNeonatal morbidityPreterm PROMSingleton gestationsMaternal morbidityPrelabor ruptureTwin gestationsOdds ratioComposite major neonatal morbidityComposite neonatal morbidityMajor neonatal morbidityMedian gestational ageMedian latency periodMajor fetal anomaliesAdjusted odds ratioCoprimary outcomesObstetric cohortNeonatal outcomesTwin neonatesGestational agePotential confoundersFetal anomaliesMorbidityMaternal outcomes and risk factors for COVID-19 severity among pregnant women
Vouga M, Favre G, Martinez-Perez O, Pomar L, Acebal LF, Abascal-Saiz A, Hernandez MRV, Hcini N, Lambert V, Carles G, Sichitiu J, Salomon L, Stirnemann J, Ville Y, de Tejada BM, Goncé A, Hawkins-Villarreal A, Castillo K, Solsona EG, Trigo L, Cleary B, Geary M, Bartels H, Al-Kharouf F, Malone F, Higgins M, Keating N, Knowles S, Poncelet C, Ribeiro-do-Valle CC, Surita F, Dantas-Silva A, Borrelli C, Luz AG, Fuenzalida J, Carvajal J, Canales MG, Hernandez O, Grechukhina O, Ko AI, Reddy U, Figueiredo R, Moucho M, Pinto PV, De Luca C, De Santis M, de Campos DA, Martins I, Garabedian C, Subtil D, Bohrer B, Da Rocha Oppermann ML, Wender MCO, Schuler-Faccini L, Sanseverino MTV, Giugliani C, Friedrich L, Scherer MH, Mottet N, Ducarme G, Pelerin H, Moreau C, Breton B, Quibel T, Rozenberg P, Giannoni E, Granado C, Monod C, Mueller D, Hoesli I, Bassler D, Heldstab S, Kölble NO, Sentilhes L, Charvet M, Deprest J, Richter J, Van der Veeken L, Eggel-Hort B, Plantefeve G, Derouich M, Calvache AJN, Lopez-Giron MC, Burgos-Luna JM, Escobar-Vidarte MF, Hecher K, Tallarek AC, Hadar E, Haratz KK, Amikam U, Malinger G, Maymon R, Yogev Y, Schäffer L, Toussaint A, Rossier MC, De Sa RAM, Grawe C, Aebi-Popp K, Radan AP, Raio L, Surbek D, Böckenhoff P, Strizek B, Kaufmann M, Bloch A, Boulvain M, Johann S, Heldstab SA, Bernasconi MT, Grant G, Feki A, Brochut AM, Giral M, Sedille L, Papadia A, Brugger RC, Weber B, Fischer T, Kahlert C, Saines KN, Cambou M, Kanellos P, Chen X, Yin M, Haessig A, Ackermann S, Baud D, Panchaud A. Maternal outcomes and risk factors for COVID-19 severity among pregnant women. Scientific Reports 2021, 11: 13898. PMID: 34230507, PMCID: PMC8260739, DOI: 10.1038/s41598-021-92357-y.Peer-Reviewed Original ResearchConceptsSevere maternal outcomesPregnant womenRisk factorsMaternal outcomesPulmonary comorbiditiesHypertensive disordersNeonatal outcomesSevere complicationsHigh riskSevere acute respiratory syndrome coronavirus 2Severe coronavirus disease-19Severe COVID-19 diseaseAcute respiratory syndrome coronavirus 2Neonatal intensive care unitSARS-CoV-2 infectionRespiratory syndrome coronavirus 2Immediate neonatal outcomeIntensive care unitSyndrome coronavirus 2COVID-19 severityCase-control studyCoronavirus disease-19SARS-CoV-2COVID-19 diseaseMaternal disease
2020
Stillbirth and fetal anomalies: secondary analysis of a case–control study
Son S, Allshouse A, Page J, Debbink M, Pinar H, Reddy U, Gibbins K, Stoll B, Parker C, Dudley D, Varner M, Silver R. Stillbirth and fetal anomalies: secondary analysis of a case–control study. BJOG An International Journal Of Obstetrics & Gynaecology 2020, 128: 252-258. PMID: 32946651, PMCID: PMC7902300, DOI: 10.1111/1471-0528.16517.Peer-Reviewed Original Research
2019
Severe maternal morbidity during delivery hospitalisation in a large international administrative database, 2008–2013: a retrospective cohort
Lipkind H, Zuckerwise L, Turner E, Collins J, Campbell K, Reddy U, Illuzi J, Merriam A. Severe maternal morbidity during delivery hospitalisation in a large international administrative database, 2008–2013: a retrospective cohort. BJOG An International Journal Of Obstetrics & Gynaecology 2019, 126: 1223-1230. PMID: 31100201, DOI: 10.1111/1471-0528.15818.Peer-Reviewed Original ResearchMeSH KeywordsAdultAustraliaCenters for Disease Control and Prevention, U.S.ComorbidityDatabases, FactualEnglandFemaleHospitalizationHumansMaternal AgeMaternal DeathMiddle AgedObstetric Labor ComplicationsPregnancyPregnancy ComplicationsPregnancy OutcomeRetrospective StudiesRisk FactorsUnited StatesYoung AdultConceptsSevere maternal morbidityMaternal morbidityDelivery hospitalisationRetrospective cohortRisk factorsSevere maternal morbidity ratesMaternal morbidity ratesAcute renal failureLife-threatening diagnosisAdvanced maternal ageLife-saving procedureLarge university hospitalChi-square testMorbidity variesPregnancy complicationsClinical characteristicsIntravascular coagulationRenal failureSevere morbidityMultivariable analysisMorbidity rateAdverse outcomesClinical differencesMaternal ageUniversity HospitalDuration of Operative Vaginal Delivery and Adverse Obstetric Outcomes
Miller E, Lai Y, Bailit J, Reddy U, Wapner R, Varner M, Thorp J, Leveno K, Caritis S, Prasad M, Tita A, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J. Duration of Operative Vaginal Delivery and Adverse Obstetric Outcomes. American Journal Of Perinatology 2019, 37: 503-510. PMID: 30895577, PMCID: PMC6754310, DOI: 10.1055/s-0039-1683439.Peer-Reviewed Original ResearchConceptsComposite adverse neonatal outcomeAdverse neonatal outcomesOperative vaginal deliveryNeonatal outcomesVaginal deliveryMulticenter observational cohortAdverse obstetric outcomesSevere perineal lacerationsObstetric outcomesPerinatal outcomesObservational cohortPerineal lacerationsPrimary cohortForceps applicationPotential confoundersSecondary analysisStrong associationOutcomesWomenCohortDurationDeliveryLacerationConfoundersForcepsEffect of Treatment of Mild Gestational Diabetes on Long-Term Maternal Outcomes
Casey B, Rice M, Landon M, Varner M, Reddy U, Wapner R, Rouse D, Biggio J, Thorp J, Chien E, Saade G, Peaceman A, Blackwell S, Van Dorsten J. Effect of Treatment of Mild Gestational Diabetes on Long-Term Maternal Outcomes. American Journal Of Perinatology 2019, 37: 475-482. PMID: 30866027, PMCID: PMC6744360, DOI: 10.1055/s-0039-1681058.Peer-Reviewed Original ResearchConceptsMild gestational diabetes mellitusGestational diabetes mellitusBody mass indexMetabolic syndromeIndex pregnancyTreatment of womenSubsequent diabetesLong-term maternal outcomesMaternal body mass indexOral glucose tolerance testMild gestational diabetesFrequency of diabetesHomeostasis model assessmentGlucose tolerance testRisk of diabetesTreatment of diabetesEffect of treatmentRace/ethnicityGestational diabetesLipid panelMaternal outcomesBlood pressureDiabetes mellitusMedical therapyNutritional counseling
2018
Cervical funneling or intra‐amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm
Saade G, Thom E, Grobman W, Iams J, Mercer B, Reddy U, Tita A, Rouse D, Sorokin Y, Wapner R, Leveno K, Blackwell S, Esplin M, Tolosa J, Thorp J, Caritis S, Vandorsten J, Network T. Cervical funneling or intra‐amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm. Ultrasound In Obstetrics And Gynecology 2018, 52: 757-762. PMID: 29155504, PMCID: PMC5960623, DOI: 10.1002/uog.18960.Peer-Reviewed Original ResearchConceptsCervical funnelingMidtrimester cervical lengthCervical lengthPreterm birthWeeks' gestationNulliparous womenMedian cervical lengthSecondary cohort analysisNulliparous pregnant womenSecond trimester ultrasoundAsymptomatic nulliparous womenMultivariable adjustmentSingleton gestationsMulticenter trialMultivariable analysisTransvaginal ultrasoundSecond trimesterPregnant womenCohort analysisGestationWomenHigh rateWeeksUltrasoundLt