2024
Large-Scale Proteomics in Early Pregnancy and Hypertensive Disorders of Pregnancy
Greenland P, Segal M, McNeil R, Parker C, Pemberton V, Grobman W, Silver R, Simhan H, Saade G, Ganz P, Mehta P, Catov J, Merz C, Varagic J, Khan S, Parry S, Reddy U, Mercer B, Wapner R, Haas D. Large-Scale Proteomics in Early Pregnancy and Hypertensive Disorders of Pregnancy. JAMA Cardiology 2024, 9: 791-799. PMID: 38958943, PMCID: PMC11223045, DOI: 10.1001/jamacardio.2024.1621.Peer-Reviewed Original ResearchArea under the receiver operating characteristic curveCase-control studyHypertensive disordersEarly pregnancyClinical dataSmall-for-gestational-age infantsPrediction of hypertensive disordersSmall-for-gestational-ageHypertensive disorders of pregnancyPrediction of HDPDisorders of pregnancyNested case-control studyPlasma samplesMulticenter observational studyStored plasma samplesReceiver operating characteristic curveBody mass indexGestational hypertensionNon-Hispanic blacksPreterm birthFetal sexFirst-trimesterNon-Hispanic whitesPregnancy outcomesMaternal race
2022
Association of N-Terminal Pro–Brain Natriuretic Peptide Concentration in Early Pregnancy With Development of Hypertensive Disorders of Pregnancy and Future Hypertension
Hauspurg A, Marsh D, McNeil R, Bairey Merz C, Greenland P, Straub A, Rouse C, Grobman W, Pemberton V, Silver R, Chen Y, Mercer B, Levine L, Hameed A, Hoffman M, Simhan H, Catov J, Reddy U, Willinger M, Davis M, Laposky A, Iams J, Dalton W, Latimer C, Polito L, Louis J, Wapner R, Fuchs K, Torres C, Lynch S, Onativia A, DiVito M, Nhan-Chang C, Basner R, Haas D, Foroud T, Perkins E, Barnes S, Winters A, McCormick C, Schubert F, Caritis S, Bickus M, Speer P, Emery S, Daftary A, Facco F, Peaceman A, Zee P, Campbell P, Shepard J, Williams C, Wing D, Wadhwa P, Nageotte M, Chung J, Rumney P, Porto M, Pham V, Parry S, Ludmir J, Elovitz M, Peters M, Araujo B, Pien G, Esplin M, Vorwaller K, Postma J, Morby V, Williams M, Meadows L, Parker C, Koch M, McFadden D, Alexander B, Yetukuri V, Hunter S, Holder T, Franklin H, DeCain M, Griggs C, Redline S, Mobley D, Surovec S, Ulanski J, Saade G. Association of N-Terminal Pro–Brain Natriuretic Peptide Concentration in Early Pregnancy With Development of Hypertensive Disorders of Pregnancy and Future Hypertension. JAMA Cardiology 2022, 7: 268-276. PMID: 35044418, PMCID: PMC8771430, DOI: 10.1001/jamacardio.2021.5617.Peer-Reviewed Original ResearchConceptsHigher NT-proBNP concentrationsNT-proBNP concentrationsHypertensive disordersSubclinical cardiac dysfunctionEarly pregnancyYear post partumHypertension 2Lower riskPregnancy outcomesCohort studyCardiac dysfunctionNatriuretic peptideN-terminal pro-brain natriuretic peptide concentrationN-terminal pro-brain natriuretic peptideEarly pregnancy body mass indexProspective multicenter observational studyPro-brain natriuretic peptidePost partumNulliparous Pregnancy Outcomes StudyFirst-trimester blood samplesAdverse pregnancy outcomesMulticenter observational studyFuture cardiovascular diseaseNatriuretic peptide concentrationsCardiovascular disease risk