2024
Large-Scale Proteomics in Early Pregnancy and Hypertensive Disorders of Pregnancy
Greenland P, Segal M, McNeil R, Parker C, Pemberton V, Grobman W, Silver R, Simhan H, Saade G, Ganz P, Mehta P, Catov J, Merz C, Varagic J, Khan S, Parry S, Reddy U, Mercer B, Wapner R, Haas D. Large-Scale Proteomics in Early Pregnancy and Hypertensive Disorders of Pregnancy. JAMA Cardiology 2024, 9: 791-799. PMID: 38958943, PMCID: PMC11223045, DOI: 10.1001/jamacardio.2024.1621.Peer-Reviewed Original ResearchArea under the receiver operating characteristic curveCase-control studyHypertensive disordersEarly pregnancyClinical dataSmall-for-gestational-age infantsPrediction of hypertensive disordersSmall-for-gestational-ageHypertensive disorders of pregnancyPrediction of HDPDisorders of pregnancyNested case-control studyPlasma samplesMulticenter observational studyStored plasma samplesReceiver operating characteristic curveBody mass indexGestational hypertensionNon-Hispanic blacksPreterm birthFetal sexFirst-trimesterNon-Hispanic whitesPregnancy outcomesMaternal race
2023
Sodium intake and the development of hypertensive disorders of pregnancy
Bank T, Grasch J, Chung J, Mercer B, McNeil R, Parry S, Saade G, Shanks A, Silver R, Simhan H, Yee L, Reddy U, Grobman W, Frey H. Sodium intake and the development of hypertensive disorders of pregnancy. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101166. PMID: 37741626, DOI: 10.1016/j.ajogmf.2023.101166.Peer-Reviewed Original ResearchConceptsHypertensive disordersHigh sodium intakeSodium intakeChronic hypertensionNonpregnant populationLow platelet count syndromeNeonatal intensive care unitNulliparous Pregnancy Outcomes StudyElevated liver enzymesGestational age neonatesFood frequency questionnaireLow sodium intakeIncidence risk ratioIntensive care unitWeeks of gestationPregnancy Outcomes StudyLack of associationChi-square testGestational hypertensionNeonatal outcomesNonpregnant stateSodium restrictionFrequency questionnairePreterm birthSingleton pregnanciesHypertensive Disorders of Pregnancy and Long-Term Maternal Cardiovascular and Metabolic Biomarkers
Battarbee A, Mele L, Landon M, Varner M, Casey B, Reddy U, Wapner R, Rouse D, Thorp J, Chien E, Saade G, Peaceman A, Blackwell S. Hypertensive Disorders of Pregnancy and Long-Term Maternal Cardiovascular and Metabolic Biomarkers. American Journal Of Perinatology 2023, 41: e1976-e1981. PMID: 37201538, PMCID: PMC10755076, DOI: 10.1055/a-2096-0443.Peer-Reviewed Original ResearchBaseline body mass indexHypertensive disordersGestational hypertensionCardiovascular biomarkersHigher baseline blood pressureLow GDF-15 levelsAssociation of HDPPresence of HDPGDF-15 levelsBaseline blood pressureHomeostatic model assessmentBody mass indexStudy of patientsSerum insulin concentrationsLongitudinal studyMultivariable linear regressionChronic hypertensionGDM cohortPregnancy hypertensionGDF-15Insulinogenic indexPostpartum interventionsBlood pressureMass indexCardiovascular dysfunction
2016
Stillbirth, hypertensive disorders of pregnancy, and placental pathology
Gibbins KJ, Silver RM, Pinar H, Reddy UM, Parker CB, Thorsten V, Willinger M, Dudley DJ, Bukowski R, Saade GR, Koch MA, Conway D, Hogue CJ, Stoll BJ, Goldenberg RL. Stillbirth, hypertensive disorders of pregnancy, and placental pathology. Placenta 2016, 43: 61-68. PMID: 27324101, PMCID: PMC5893308, DOI: 10.1016/j.placenta.2016.04.020.Peer-Reviewed Original ResearchConceptsPlacental pathologyParenchymal infarctionLive birthsPreterm stillbirthSimilar clinical risk factorsStillbirth Collaborative Research NetworkPopulation-based cohort studyFetal vascular lesionsClinical risk factorsFeto-placental ratioGestational hypertensionRetroplacental hematomaHypertensive disordersCohort studyPlacental lesionsVascular lesionsAvascular villiFibrin depositionRisk factorsVascular thrombiStillbirthPregnancySecondary analysisInfarctionGH