2018
Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis
Ponath G, Lincoln MR, Levine-Ritterman M, Park C, Dahlawi S, Mubarak M, Sumida T, Airas L, Zhang S, Isitan C, Nguyen TD, Raine CS, Hafler DA, Pitt D. Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis. Nature Communications 2018, 9: 5337. PMID: 30559390, PMCID: PMC6297228, DOI: 10.1038/s41467-018-07785-8.Peer-Reviewed Original ResearchConceptsMultiple sclerosisAstrocyte responseRisk variantsLocal autoimmune inflammationPeripheral immune cellsCentral nervous system cellsPeripheral immune systemCultured human astrocytesNervous system cellsNF-κB signalingCNS accessDysfunctional lymphocytesAstroglial functionAutoimmune inflammationLymphocytic infiltrateLymphocyte recruitmentImmune cellsGenetic risk allelesGenetic risk variantsMS lesionsMS susceptibilityHuman astrocytesLesion sizeImmune systemSystem cells
2017
DNA single-strand break-induced DNA damage response causes heart failure
Higo T, Naito AT, Sumida T, Shibamoto M, Okada K, Nomura S, Nakagawa A, Yamaguchi T, Sakai T, Hashimoto A, Kuramoto Y, Ito M, Hikoso S, Akazawa H, Lee JK, Shiojima I, McKinnon PJ, Sakata Y, Komuro I. DNA single-strand break-induced DNA damage response causes heart failure. Nature Communications 2017, 8: 15104. PMID: 28436431, PMCID: PMC5413978, DOI: 10.1038/ncomms15104.Peer-Reviewed Original ResearchConceptsPressure overload-induced heart failureOverload-induced heart failureHeart failureSingle-strand breaksNF-κB signalingNew therapeutic strategiesSSB accumulationDDR activationInflammatory cytokinesTherapeutic strategiesUnrepaired single-strand breaksDNA damageDNA single-strand breaksCausative roleDNA damage responseGenetic deletionPathogenesisActivationPivotal roleFailureDamage responseHeartCritical roleCytokinesMice