2024
Use of The Risk Assessment and Prediction Tool to Predict Same-day Discharge After Primary Hip and Knee Arthroplasty
Dupont M, Held M, Shah R, Cooper H, Neuwirth A, Hickernell T. Use of The Risk Assessment and Prediction Tool to Predict Same-day Discharge After Primary Hip and Knee Arthroplasty. JAAOS Global Research And Reviews 2024, 8: e22.00269. PMID: 38456719, PMCID: PMC10923310, DOI: 10.5435/jaaosglobal-d-22-00269.Peer-Reviewed Original ResearchConceptsSame-day dischargeTotal knee arthroplastyTotal hip arthroplastyTertiary care centerPreoperative screening toolReceiver operating characteristic curveRAPT scoreScreening toolLogistic regression analysisAssociated with same-day dischargeKnee arthroplastyCutoff valuePreoperative notesPredictive valueCare centerPatientsCharacteristic curveSame-dayDischarge dispositionDischarge planningRegression analysisArthroplastyPositive associationScoresCutoff
2023
Is There an Implicit Racial Bias in the Case Order of Elective Total Joint Arthroplasty?
Kaidi A, Hammoor B, Tyler W, Geller J, Cooper H, Hickernell T. Is There an Implicit Racial Bias in the Case Order of Elective Total Joint Arthroplasty? Journal Of Racial And Ethnic Health Disparities 2023, 11: 1-6. PMID: 37095288, DOI: 10.1007/s40615-022-01492-3.Peer-Reviewed Original ResearchConceptsSurgical start timeTotal joint arthroplastyTotal hip arthroplastyMultivariable logistic regressionOdds ratioJoint arthroplastyArthroplasty fellowship-trained surgeonsElective total joint arthroplastyNon-Hispanic black patientsElective total hip arthroplastyPrimary total joint arthroplastySurgical case orderLarge academic medical centerFellowship-trained surgeonsAcademic medical centerSelf-reported raceTKA patientsBlack patientsAdverse outcomesSurgical typePatient raceTotal kneeInclusion criteriaHip arthroplastyMedical Center
2022
Perioperative Intravenous Glucocorticoids in Total Joint Arthroplasty: A Systematic Review
Ruberto R, Farah O, Lopez C, Hickernell T. Perioperative Intravenous Glucocorticoids in Total Joint Arthroplasty: A Systematic Review. Journal Of The American Academy Of Orthopaedic Surgeons 2022, 31: e94-e106. PMID: 36580055, DOI: 10.5435/jaaos-d-22-00232.Peer-Reviewed Original ResearchConceptsTotal joint arthroplastyPostoperative surgical complicationsPostoperative painSystematic reviewPerioperative glucocorticoidsPerioperative steroidsPostoperative nauseaSurgical complicationsGlucocorticoid administrationJoint arthroplastyMultimodal pain controlPerioperative glucocorticoid administrationPerioperative steroid administrationPostoperative opioid utilizationRescue medication useAdditional randomized trialsCommon orthopaedic proceduresNotable adverse effectsRange of motionIntravenous glucocorticoidsHospital lengthOpioid utilizationPain controlPain scoresPostoperative length
2021
State Medical Cannabis Laws Associated With Reduction in Opioid Prescriptions by Orthopaedic Surgeons in Medicare Part D Cohort.
Lopez C, Boddapati V, Jobin C, Hickernell T. State Medical Cannabis Laws Associated With Reduction in Opioid Prescriptions by Orthopaedic Surgeons in Medicare Part D Cohort. Journal Of The American Academy Of Orthopaedic Surgeons 2021, 29: e188-e197. PMID: 32404683, DOI: 10.5435/jaaos-d-19-00767.Peer-Reviewed Original ResearchConceptsMedical cannabis lawsMedicare Part D patientsState medical cannabis lawsTotal daily dosesDaily dosesOpioid medicationsOpioid prescriptionsOrthopaedic surgeonsOpioid prescribingD patientsSignificant reductionPopulation-based ecological studyTotal opioid prescriptionsCannabis lawsAnalgesic optionsAnalgesic alternativeOpioid useHigh prescribersOrthopedic patientsPatient cohortD cohortSignificant associationPatient accessMedicationsOpioids
2020
Opioid Prescription Consumption Patterns After Total Joint Arthroplasty in Chronic Opioid Users Versus Opioid Naive Patients
Kaidi A, Lakra A, Jennings E, Neuwirth A, Geller J, Shah R, Cooper H, Hickernell T. Opioid Prescription Consumption Patterns After Total Joint Arthroplasty in Chronic Opioid Users Versus Opioid Naive Patients. JAAOS Global Research And Reviews 2020, 4: e20.00066. PMID: 32656479, PMCID: PMC7322780, DOI: 10.5435/jaaosglobal-d-20-00066.Peer-Reviewed Original ResearchConceptsChronic opioid usersOpioid-naive patientsMorphine equivalent dosesOpioid prescriptionsOpioid useChronic usersOpioid usersOrthopaedic departmentChronic preoperative opioid useTotal joint arthroplasty outcomesEquivalent dosesElective total hipJoint arthroplasty outcomesMore opioid prescriptionsPreoperative opioid useTotal joint arthroplastyUrban medical centerCurrent opioid epidemicNaive patientsOpioid prescribingPostoperative periodPrescribing patternsPostoperative intervalsTotal hipArthroplasty outcomes
2018
Should Cannabinoids Be Added to Multimodal Pain Regimens After Total Hip and Knee Arthroplasty?
Hickernell T, Lakra A, Berg A, Cooper H, Geller J, Shah R. Should Cannabinoids Be Added to Multimodal Pain Regimens After Total Hip and Knee Arthroplasty? The Journal Of Arthroplasty 2018, 33: 3637-3641. PMID: 30170713, DOI: 10.1016/j.arth.2018.07.027.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnalgesics, OpioidArthroplasty, Replacement, HipArthroplasty, Replacement, KneeCannabinoid Receptor AgonistsCannabinoidsClinical ProtocolsCohort StudiesDronabinolFemaleHumansLength of StayMaleMiddle AgedMorphinePain ManagementPain MeasurementPain, PostoperativePatient SatisfactionPhysical Therapy ModalitiesRetrospective StudiesConceptsLength of stayNausea/vomitingMorphine equivalentsTotal joint arthroplastyDronabinol groupTJA patientsPhysical therapyVisual analog scale pain scoreVisual analog scale scoreMultimodal pain regimenOpioid morphine equivalentsPost-arthroplasty patientsPrimary TJA patientsTotal morphine equivalentsScale pain scoresAnalog scale scoreBody mass indexEffects of dronabinolMann-Whitney U testT-testStudent's t-testAnesthesiologists (ASA) scoreMultimodal painPain regimenPain scoresRisk factors for conversion surgery to total hip arthroplasty of a hemiarthroplasty performed for a femoral neck fracture
Grosso M, Danoff J, Thacher R, Murtaugh T, Hickernell T, Shah R, Macaulay W. Risk factors for conversion surgery to total hip arthroplasty of a hemiarthroplasty performed for a femoral neck fracture. Hip International 2018, 28: 168-172. PMID: 29890908, DOI: 10.1177/1120700018768654.Peer-Reviewed Original ResearchConceptsFemoral neck fracturesLeg length discrepancyConversion surgeryAbsence of dementiaNeck fracturesRisk factorsIndex surgeryHip arthroplastyYounger ageHigher body mass indexContralateral femoral headConversion of hemiarthroplastyBody mass indexMultivariate logistic regressionCase-control studyTotal hip arthroplastyRisk of conversionFemoral head sizeHead sizeControl patientsPatient characteristicsMass indexLength discrepancyUnivariate analysisIntraoperative considerations
2017
Creation of an Online Wiki Improves Post-Operative Surgical Protocol Adherence in Arthroplasty Patients
Swart E, Miller D, Hickernell T, Bozic K, Geller J, Macaulay W. Creation of an Online Wiki Improves Post-Operative Surgical Protocol Adherence in Arthroplasty Patients. The Journal Of Arthroplasty 2017, 32: 2319-2324.e6. PMID: 28372915, DOI: 10.1016/j.arth.2017.02.081.Peer-Reviewed Original ResearchConceptsPerioperative care pathwaysPost-operative protocolsProtocol adherenceCare pathwayUnnecessary testingOverall protocol adherencePain control regimenLower extremity arthroplastyHigh-volume clinical settingArthroplasty patientsPathway adherenceRetrospective reviewControl regimenInpatient careLaboratory ordersClinical settingAdherenceCarePatientsPractical barriersRegimenArthroplastyYearsPathwayMonths
2014
Proteomic identification of 14‐3‐3ϵ as a linker protein between pERK1/2 inhibition and BIM upregulation in human osteosarcoma cells
Kim KO, Hsu AC, Lee HG, Patel N, Chandhanayingyong C, Hickernell T, Lee F. Proteomic identification of 14‐3‐3ϵ as a linker protein between pERK1/2 inhibition and BIM upregulation in human osteosarcoma cells. Journal Of Orthopaedic Research® 2014, 32: 848-854. PMID: 24536031, DOI: 10.1002/jor.22598.Peer-Reviewed Original ResearchConceptsPERK1/2 inhibitionHuman osteosarcoma cellsBim expressionSubset of patientsOsteosarcoma cellsConventional cytotoxic agentsConventional cytotoxic treatmentAnti-cancer effectsInhibition of pERK1/2Pro-apoptotic mechanismsMultifocal osteosarcomaMultimodality chemotherapyCytotoxic treatmentUpregulation of BimOsteosarcoma treatmentOsteosarcoma cell deathCytotoxic agentsExpression of BimPotential mediatorsTreatment of PD98059UpregulationTreatmentPD98059 treatmentInhibitionCell death
2010
Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome
Rucci F, Notarangelo L, Fazeli A, Patrizi L, Hickernell T, Paganini T, Coakley K, Detre C, Keszei M, Walter J, Feldman L, Cheng H, Poliani P, Wang J, Balter B, Recher M, Andersson E, Zha S, Giliani S, Terhorst C, Alt F, Yan C. Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 3024-3029. PMID: 20133615, PMCID: PMC2840307, DOI: 10.1073/pnas.0914865107.Peer-Reviewed Original ResearchConceptsLIG4 mutationsGrowth retardationPeripheral T lymphocytesLIG4 syndromeLow-affinity antibodiesLeaky SCIDHomozygous mutant miceAnergic phenotypeHigh-affinity antibodiesT lymphocytesMouse modelB cell developmentMutant miceDevelopmental delayDecreased life spanTumor developmentFacial dysmorphismLymphocyte developmentMiceAutoreactive specificitiesNonhomologous end-joining repair pathwaySyndromeHigh rateSCIDVariable degrees