Featured Publications
Applications of Digital Microscopy and Densely Connected Convolutional Neural Networks for Automated Quantification of Babesia-Infected Erythrocytes
Durant TJS, Dudgeon SN, McPadden J, Simpson A, Price N, Schulz WL, Torres R, Olson EM. Applications of Digital Microscopy and Densely Connected Convolutional Neural Networks for Automated Quantification of Babesia-Infected Erythrocytes. Clinical Chemistry 2021, 68: 218-229. PMID: 34969114, DOI: 10.1093/clinchem/hvab237.Peer-Reviewed Original ResearchVery Deep Convolutional Neural Networks for Morphologic Classification of Erythrocytes
Durant T, Olson EM, Schulz WL, Torres R. Very Deep Convolutional Neural Networks for Morphologic Classification of Erythrocytes. Clinical Chemistry 2017, 63: 1847-1855. PMID: 28877918, DOI: 10.1373/clinchem.2017.276345.Peer-Reviewed Original ResearchConceptsConvolutional neural networkNeural networkDeep convolutional neural networkDense shortcut connectionsNeural network designSlow manual processSignificant labor costsClassification of erythrocytesWeb applicationCapable machinesUnseen dataShortcut connectionsManual processEnsemble model predictionsDigital imagesPrecision metricsArchitectural considerationsNetwork designAutomated profilingClassification frequencyMisclassification errorPractical performanceFinal databaseHarmonic meanNetwork
2023
Data Analytics in Clinical Laboratories: Advancing Diagnostic Medicine in the Digital Age
Merrill A, Durant T, Baron J, Klutts J, Obstfeld A, Peaper D, Stoffel M, Wheeler S, Zaydman M. Data Analytics in Clinical Laboratories: Advancing Diagnostic Medicine in the Digital Age. Clinical Chemistry 2023, 69: 1333-1341. PMID: 37962514, DOI: 10.1093/clinchem/hvad183.Commentaries, Editorials and LettersCybersecurity and Information Assurance for the Clinical Laboratory
Patel A, Williams C, Hart S, Garcia C, Durant T, Cornish T, McClintock D. Cybersecurity and Information Assurance for the Clinical Laboratory. The Journal Of Applied Laboratory Medicine 2023, 8: 145-161. PMID: 36610432, DOI: 10.1093/jalm/jfac119.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInformation securityInformation assuranceZero-trust security modelSensitive healthcare informationMalicious actorsSecurity modelFuture cyberattacksCybersecurity controlsCybersecurity risksHealthcare informationFuture of healthcareCybersecurityCyberattacksExtended downtimeIntegrated systemSecurityAssurance strategiesPatient dataHealthcare organizationsDowntimePatient care operationsInteroperabilityHigh qualityAssuranceHealthcareThe Roadmap to Interoperability and Laboratory Data: Current State and Next Steps
Chang T, Herman D, McClintock D, Durant T. The Roadmap to Interoperability and Laboratory Data: Current State and Next Steps. The Journal Of Applied Laboratory Medicine 2023, 8: 226-228. PMID: 36610435, DOI: 10.1093/jalm/jfac082.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHumansLaboratoriesFrom Data to Wisdom: Biomedical Knowledge Graphs for Real-World Data Insights
Hänsel K, Dudgeon S, Cheung K, Durant T, Schulz W. From Data to Wisdom: Biomedical Knowledge Graphs for Real-World Data Insights. Journal Of Medical Systems 2023, 47: 65. PMID: 37195430, PMCID: PMC10191934, DOI: 10.1007/s10916-023-01951-2.Commentaries, Editorials and LettersConceptsKnowledge graphReal-world dataGraph modelBiomedical data integrationGraph data modelIntegrated Knowledge GraphBiomedical knowledge graphsElectronic health recordsData integrationData insightsData modelInsight generationBiomedical informationHealth recordsArt researchGraphNovel approachCombination of dataDisease phenotypingInformationPrecision medicine researchHealthcareIntegrationEHRIntriguing opportunity
2022
A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid use
Choucair I, Villalba C, Vera M, Cassella-Mclane G, Durant T, El-Khoury J. A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid use. Clinical Biochemistry 2022, 112: 6-10. PMID: 36535386, DOI: 10.1016/j.clinbiochem.2022.12.009.Peer-Reviewed Original ResearchConceptsConcentrations of hydrocodoneMean ratioOxycodone pillsPrescription complianceOpioid useUDT resultsMedication recordsOxycodoneAdditional opiatesPatientsHydromorphoneLarger sample sizeAbstractTextHydrocodoneDrug abuseLiquid chromatography-tandem mass spectrometryDrug testingChromatography-tandem mass spectrometryLC-MS/MSFurther validationPreliminary studySample sizeOpiatesSensitive methodPillsContamination of clinical blood samples with crystalloid solutions: An experimental approach to derive multianalyte delta checks
Choucair I, Lee ES, Vera MA, Drongmebaro C, El-Khoury JM, Durant TJS. Contamination of clinical blood samples with crystalloid solutions: An experimental approach to derive multianalyte delta checks. Clinica Chimica Acta 2022, 538: 22-28. PMID: 36309069, DOI: 10.1016/j.cca.2022.10.011.Peer-Reviewed Original ResearchConceptsWet chemistry experimentsAn Unusual Case of High 6-Monoacetylmorphine and Low Morphine in Urine: Heroin Abuse or Analytical Error?
Choucair I, Cassella-Mclane G, Rogers K, Durant T, El-Khoury J. An Unusual Case of High 6-Monoacetylmorphine and Low Morphine in Urine: Heroin Abuse or Analytical Error? Clinical Chemistry 2022, 68: 1344-1345. PMID: 37619530, DOI: 10.1093/clinchem/hvac110.Peer-Reviewed Case Reports and Technical NotesMachine Learning in Healthcare: Mapping a Path to Title 21
Marin MJ, Van Wijk XMR, Durant TJS. Machine Learning in Healthcare: Mapping a Path to Title 21. Clinical Chemistry 2022, 68: 609-610. PMID: 36149375, DOI: 10.1093/clinchem/hvab285.Commentaries, Editorials and LettersAdvances in molecular infectious diseases testing in the time of COVID-19
Peaper DR, Kerantzas CA, Durant TJS. Advances in molecular infectious diseases testing in the time of COVID-19. Clinical Biochemistry 2022, 117: 94-101. PMID: 35181291, PMCID: PMC8843810, DOI: 10.1016/j.clinbiochem.2022.02.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Infectious diseasesRespiratory syndrome coronavirus 2Syndrome coronavirus 2COVID-19Public health needsCoronavirus 2Health needsDiagnostic testingCoronavirus diseaseLaboratory responseWidespread testingDiseaseCOVID-19 pandemicLaboratory medicineSample collectionPandemicTestingChallenging eventsDiagnostic manufacturersQuality Management to Improve CSF Gram Stain Turnaround Time
Kerantzas CA, Merwede JP, Fadlallah H, Durant TJS, Peaper DR. Quality Management to Improve CSF Gram Stain Turnaround Time. The Journal Of Applied Laboratory Medicine 2022, 7: 782-787. PMID: 35018424, DOI: 10.1093/jalm/jfab165.Peer-Reviewed Original Research
2021
Artificial Intelligence and Mapping a New Direction in Laboratory Medicine: A Review
Herman DS, Rhoads DD, Schulz WL, Durant TJS. Artificial Intelligence and Mapping a New Direction in Laboratory Medicine: A Review. Clinical Chemistry 2021, 67: 1466-1482. PMID: 34557917, DOI: 10.1093/clinchem/hvab165.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsArtificial intelligenceML systemsModern artificial intelligenceAI/MLAdoption of MLExpert human operatorMachine learning methodsModern computingCommunication infrastructureHuman operatorLearning methodsInformation systemsWidespread digitizationIntelligenceHealth informationTechnologyImplementationComputingBrief introductionBest practicesSystemDigitizationInfrastructureTaskInformationCO-Oximetry Interference in a Patient with Dyspnea Refractory to Oxygen Therapy
Binns TC, Koch CD, Durant TJS, El-Khoury JM. CO-Oximetry Interference in a Patient with Dyspnea Refractory to Oxygen Therapy. The Journal Of Applied Laboratory Medicine 2021, 6: 1671-1676. PMID: 34383919, DOI: 10.1093/jalm/jfab071.Peer-Reviewed Case Reports and Technical NotesLongitudinal Assessment of SARS-CoV-2 Anti-Nucleocapsid and anti-Spike-1-RBD Antibody Testing Following PCR-Detected SARS-CoV-2 Infection
El-Khoury JM, Schulz WL, Durant TJS. Longitudinal Assessment of SARS-CoV-2 Anti-Nucleocapsid and anti-Spike-1-RBD Antibody Testing Following PCR-Detected SARS-CoV-2 Infection. The Journal Of Applied Laboratory Medicine 2021, 6: jfab030-. PMID: 33822964, PMCID: PMC8083453, DOI: 10.1093/jalm/jfab030.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionDays post-PCR positivitySARS-CoV-2-positive cohortRBD antibodiesAnti-SARSSerologic assaysSARS-CoV-2 serologic assaysDiagnostic sensitivityElecsys Anti-SARSCoV-2 SResidual clinical samplesAntibody testingRemote historyCoV-2S1-RBDUS populationLongitudinal assessmentInfection statusInfectionDiagnostic aidCohortTime pointsDiscrepant resultsClinical samplesPositivityToward Dynamic Risk Prediction of Outcomes After Coronary Artery Bypass Graft
Mori M, Durant TJS, Huang C, Mortazavi BJ, Coppi A, Jean RA, Geirsson A, Schulz WL, Krumholz HM. Toward Dynamic Risk Prediction of Outcomes After Coronary Artery Bypass Graft. Circulation Cardiovascular Quality And Outcomes 2021, 14: e007363. PMID: 34078100, PMCID: PMC8635167, DOI: 10.1161/circoutcomes.120.007363.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graftArtery bypass graftIntraoperative variablesBypass graftLogistic regression modelsOperative mortalityC-statisticCoronary artery bypass graft casesThoracic Surgeons Adult Cardiac Surgery DatabaseAdult Cardiac Surgery DatabaseMean patient ageGood c-statisticCardiac Surgery DatabaseBrier scoreRisk restratificationDynamic risk predictionIntraoperative deathsPostoperative complicationsPostoperative eventsAdverse eventsPatient agePreoperative variablesRegression modelsGraft casesSurgery DatabasePreventing pseudohyponatremia: Intralipid®-based lipemia cutoffs for sodium are inappropriate
Koch CD, Vera MA, Messina J, Price N, Durant TJS, El-Khoury JM. Preventing pseudohyponatremia: Intralipid®-based lipemia cutoffs for sodium are inappropriate. Clinica Chimica Acta 2021, 520: 63-66. PMID: 34077753, DOI: 10.1016/j.cca.2021.05.032.Peer-Reviewed Original ResearchConceptsHyperlipidemic samplesIndirect ion-selective electrode methodSodium concentrationHuman samplesIndirect ISE methodPatient plasma samplesPseudohyponatremiaRoche CobasMajor contributing factorExcess lipidsIntralipidPlasma samplesBeckman CoulterHyperlipidemiaLipemic indexArtifactual decreaseClinical laboratoriesRoche Cobas 8000LipemiaIon selective electrode methodDirect ISEIndirect ISECobas 8000Contributing factorStrong positive correlationClinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection
McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJS, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection. PLOS ONE 2021, 16: e0243291. PMID: 33788846, PMCID: PMC8011821, DOI: 10.1371/journal.pone.0243291.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionYale New Haven HealthSARS-CoV-2Hospital mortalityRisk of admissionMale sexRisk factorsSARS-CoV-2 testingInvasive mechanical ventilationSevere acute respiratory syndrome virusBurden of diseaseRT-PCR testingAcademic health systemDiverse patient populationsRespiratory syndrome virusEthnic groupsAdult patientsClinical characteristicsDischarge dispositionRespiratory supportPrimary outcomeTreatment guidelinesMechanical ventilationRetrospective studyPatient populationCentralized vs Decentralized Molecular Infectious Disease Testing
Campbell S, Anderson N, Babady E, Durant TJS, Fisher A, Moore N. Centralized vs Decentralized Molecular Infectious Disease Testing. Clinical Chemistry 2021, 67: 713-719. PMID: 33517379, DOI: 10.1093/clinchem/hvaa318.Commentaries, Editorials and Letters
2020
Evaluation of a Risk Stratification Model Using Preoperative and Intraoperative Data for Major Morbidity or Mortality After Cardiac Surgical Treatment
Durant TJS, Jean RA, Huang C, Coppi A, Schulz WL, Geirsson A, Krumholz HM. Evaluation of a Risk Stratification Model Using Preoperative and Intraoperative Data for Major Morbidity or Mortality After Cardiac Surgical Treatment. JAMA Network Open 2020, 3: e2028361. PMID: 33284333, DOI: 10.1001/jamanetworkopen.2020.28361.Peer-Reviewed Original Research