2021
Protective impacts of household-based tuberculosis contact tracing are robust across endemic incidence levels and community contact patterns
Havumaki J, Cohen T, Zhai C, Miller JC, Guikema SD, Eisenberg MC, Zelner J. Protective impacts of household-based tuberculosis contact tracing are robust across endemic incidence levels and community contact patterns. PLOS Computational Biology 2021, 17: e1008713. PMID: 33556077, PMCID: PMC7895355, DOI: 10.1371/journal.pcbi.1008713.Peer-Reviewed Original ResearchConceptsTuberculosis burdenCommunity transmissionGlobal tuberculosis control targetsSustained community transmissionHigh-incidence settingsHigh disease burdenTuberculosis contact tracingLow tuberculosis burdenHousehold contactsHousehold transmissionDisease burdenVaried incidenceContact patternsIncidence levelsProtective impactEpidemiological settingsInfected individualsNew casesProtective benefitsContact tracingCommunity contactsSuch interventionsInterventionBurdenProactive case
2020
Time Since Infection and Risks of Future Disease for Individuals with Mycobacterium tuberculosis Infection in the United States
Menzies NA, Swartwood N, Testa C, Malyuta Y, Hill AN, Marks SM, Cohen T, Salomon JA. Time Since Infection and Risks of Future Disease for Individuals with Mycobacterium tuberculosis Infection in the United States. Epidemiology 2020, 32: 70-78. PMID: 33009253, PMCID: PMC7707158, DOI: 10.1097/ede.0000000000001271.Peer-Reviewed Original ResearchMeSH KeywordsAdultHumansIncidenceLatent TuberculosisMycobacterium tuberculosisProbabilityRiskTuberculosisUnited StatesConceptsLatent TB infectionMycobacterium tuberculosis infectionTB infectionTuberculosis infectionTB natural historyRisk of tuberculosisMost TB casesRate of progressionYounger age groupsLower future riskTransmission dynamic modelTB casesTB riskPrevalent infectionProgression riskLifetime riskRisk factorsIncidence trendsClinical diseaseCumulative riskGeneral populationAverage ageNew infectionsUS populationAge groups
2011
Spontaneous Emergence of Multiple Drug Resistance in Tuberculosis before and during Therapy
Colijn C, Cohen T, Ganesh A, Murray M. Spontaneous Emergence of Multiple Drug Resistance in Tuberculosis before and during Therapy. PLOS ONE 2011, 6: e18327. PMID: 21479171, PMCID: PMC3068161, DOI: 10.1371/journal.pone.0018327.Peer-Reviewed Original ResearchConceptsMultiple drug resistanceDrug resistanceInitial treatment regimensTB control programsAnti-TB drugsDrug-resistant formsEmergence of resistanceFunctional monotherapyTreatment regimensCombination therapyTB strainsTuberculosis treatmentTherapy rangeM. tbTB bacilliMultidrug resistanceM. tuberculosisDifferent antibioticsTherapyTuberculosisInfected hostControl programsResistant formsTBMonotherapy
2003
Transmission Dynamics and Control of Severe Acute Respiratory Syndrome
Lipsitch M, Cohen T, Cooper B, Robins JM, Ma S, James L, Gopalakrishna G, Chew SK, Tan CC, Samore MH, Fisman D, Murray M. Transmission Dynamics and Control of Severe Acute Respiratory Syndrome. Science 2003, 300: 1966-1970. PMID: 12766207, PMCID: PMC2760158, DOI: 10.1126/science.1086616.Peer-Reviewed Original ResearchConceptsSevere acute respiratory syndromeAcute respiratory syndromeRespiratory syndromePublic health effortsDetailed epidemiologic dataSingle infectious caseEpidemiologic dataSecondary casesAbsence of interventionInfectious casesEpidemic curveTransmission dynamicsSyndromeReproductive numberControl measuresIllnessIllnesses of humansMonths